Putthoff/Robbins 3 Flashcards
What are the 5 plasma cell neoplasms/disorders?
MM, LL, Heavy Chain Disease, Primary or immunocyte associated amyloidosis, and MGUS.
What is the phenomenon in MM with RBCs?
Rouleaux formation of RBCs
What does definitive diagnosis of MM require? What are 3 specific things we need for diagnosis?
BM examination
BM shows greater than 30% plasma cells with atypia
Greater than 3 gm/dL of Ig
More than 6 mg/dL of urinary bence jones proteins
Two types of heavy chain disease and what is significant to remember about each one?
Most common form is IgA or alpha. GI tract involvement
Second most common form is IgG or Franklin disease/gamma. Palatal edema.
What are the two variants of MM? How many of these cats progress to MM?
Plasmacytoma which is more of a mass in bone almost always progresses to MM. Mass outside of bone can be respected.
Smoldering myeloma is defined by a lack of symptoms but still has the M spike. 75% progress to MM
What is a clinical feature that MM shares with LL?
Hyper viscosity
Two CD markers for MM, but also plasma cell tumors in general?
CD138 and CD56
What is the most common plasma cell disorder?
MGUS
What patient population is MGUS commonly seen in and how often do these guys progress to MM? By definition, what is MGUS?
5% of 70 year olds
1% per year progress to MM
Asymptomatic and less than 3gm of M protein
Virtually all cases of lymphoplasmacytic lymphoma are associated with what mutation?
Acquired MYD88
What two things are not commonly seen in LL?
Bone lesions and secretion of Ig light chains
3 clinical signs/symptoms found in mantle cell lymphoma? How is the prognosis of Mantle cell?
Painless LAD, spleen/BM/liver and then GI
Poor
What is the unusual phenomenon found in mantle cell lymphomas?
Lympomatoid polyposis
What is the specific transformation associated with marginal zone lymphoma?
Polyclonal to monoclonal
What other lymphomas follow this polyclonal to monoclonal transformation?
EBV induced lymphomas
What is the classic patient with hair cell leukemia?
Middle aged white male
What is the most common symptom of hairy cell leukemia?
What are three other symptoms that can commonly arise as well?
Prognosis of Hairy?
Massive spleen
Pancytopenia, splenic dysfunction and infections…commonly atypical mycobacterial ones
Excellent
Where are peripheral T cell tumors most common in the world?
Asia
What are the 6 peripheral T cell and NK cell neoplasms?
Peripheral T cell lymphoma Anaplastic Large Cell Lymphoma Adult T cell leukemia Mycosis fungus Large granular lymphocytic leukemia Extranodal NK/t cell lymphoma
What is the mutation in anaplastic large cell lymphomas, what is the typical patient, how does the tumor present, and what is the prognosis?
ALK gene mutaiton
Children and young adults
Soft tissue masses
Very good prognosis even though T cell lymphomas typically have horrible prognosis
What CD marker is anaplastic?
30+
Extranodal NK/T cell lymphoma is highly associated with what?
EBV
What is the most common place anaplastic large cell lymphomas like to cluster? Where do extranodal NKt cell lymphomas like to invade and cause?
Venules and sinuses
Small vessels and necrosis
What is the most common cancer diagnosed in teens 15-19?
HL
Nodular sclerosis is not commonly associated with what? Mixed cellularity is commonly associated with what? Lymphocyte rich is associated with what in 40% of cases? Which HL type is associated with EBV over 90% of the time? Which HL type is found in HIV patients most of the time? Which type is EBV not associated with?
EBV EBV EBV Lymphocyte depleted Lymphocyte depleted Lymphocyte predominance
