Putoff/Robbins WBC Flashcards
2 essential properties of HSC that are required for the maintenance of blood products?
Pluripotency and self renewal
Where is the chief site of blood cell ruction in the fetus and then in the adult?
Liver
BM of axial skeleton
In adults, bone marrow biopsy and aspiration is typically performed where?
PSIS
What two blood products do we find circulating in the peripheral blood? The blood is their home?
Platelets and RBC
What blood products are found more often in the tissue?
Leukocytes
What are the top two most common leukocytes found in the body?
Neutrophils and lymphocytes
Platelet production can be increased by how much for need?
10 fold
Two places that EPO is produced and what hemoglobin level is EPO released at a constant rate?
Kidney and liver
Above 10, EPO will be released at a constant rate
How long does it take a RBC to move from bone marrow to peripheral blood? How many of our RBCs do we replace a day?
4 days
1%
What two immature cells are found in a left shift when there is a severe infection? What does the nucleus of each cell look like?
Metamyelocyte, called the juvenile granulocytes which has an indented nucleus
Band with a hotshot nucleus.
When you spin down the blood, what are the three layers top to bottom?
Plasma (water and proteins)
Buffy (WBCs and platelets)
RBCs
Difference between plasma and serum?
Serum is whats left of the plasma after it clots
Top 3 proteins in the blood?
Albumin, fibrinogen and globulin
3 characteristics of solid tumors that do not apply to lymphomas and Leukemias?
Metastasis, differentiation, and and vascularity
80% of circulating lymphocytes are what kind of cell?
T cells
