pulmunary delivery Flashcards

1
Q

What is the rationale for pulmonary drug delivery?

A

It provides rapid onset, bypasses first-pass metabolism, requires a smaller dose, and can target both local and systemic effects.

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2
Q

Describe the anatomy of the lungs relevant to drug delivery.

A

Lungs have a large surface area (~100 m²) with 300 million alveoli and extensive capillary contact, which supports rapid drug absorption.

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3
Q

What is the typical pH and humidity in the lungs?

A

The lung environment has a pH of about 6.6 and 99% relative humidity.

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4
Q

Name some advantages of the inhaled route of drug delivery.

A
  1. Non-invasive
  2. avoids first-pass metabolism
  3. rapid action
  4. localized or systemic effects.
  5. smaller dose required which means fewer side effects
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5
Q

What are some disadvantages of the inhaled route?

A
  1. Low bioavailability (~8%),
  2. specific particle size requirements
  3. need for device coordination and some devices are bulky
  4. potential for side effects like oral thrush.
  5. need proper device technique9
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6
Q

What types of dry powder inhalers (DPIs) exist?

A

Single-unit dose, multiple-unit dose, and multidose DPIs.

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7
Q

What particle size is ideal for pulmonary drug delivery?

A

Particles between 1-5µm are optimal for reaching the lungs without being phagocytosed.

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8
Q

Why is lactose often used in DPIs?

A

It acts as a carrier that is adhesive enough for stability but weak enough to allow drug release

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9
Q

what is brownian diffusion?

A

the random movement of tiny particles (like molecules or small drug particles) as they constantly bump into other particles, such as air or liquid molecules.

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10
Q

What are some current and future challenges in pulmonary drug delivery?

A

Systemic delivery (e.g., Afrezza), propellant issues, biopharmaceuticals, and controlled-release formulations.

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