lipid based drug delivery systems

Question 1

briefly explain the four classes of LBDDS

Answer 1

class 1. g solubility, g permeability
class 2. b solubility, g permeability
class 3. opposite.
class 4. neither good

Question 2

What are the main benefits of lipid-based drug delivery systems?

Answer 2

1. LBDDS can improve drug solubility
2. enhance bioavailability
3. protect drugs from degradation
4. offer controlled release.

Question 3

explain the components of a LBDDS

Answer 3

1. the lipid (oils etc)
2. a surfactant. (amphipathic molecules.)
3. a co-solvent (low molecular weigh alcohols, propylene glycol_)

Question 4

how would u make a lbdds

Answer 4

1. a simple mixing (heat, sonication, particle size reduction.)
2. put in a soft or hard gelatine capsule.
3. a formulation process. ( drug plus oil, surfactant etc.)

Question 5

key advantage of LFCS Type 2 formulations

Answer 5

Enhanced drug dispersion in the GI tract, which increases solubility and bioavailability for poorly soluble drugs.

Question 6

What are the characteristic features of LFCS Types I through IV?

Answer 6

• Type I: Simple oils, no surfactants, low drug-loading capacity.
• Type II: Self-emulsifying formulations with oils and surfactants.
• Type III: Self-microemulsifying with higher surfactant content.
• Type IV: High surfactant and co-surfactant, very low oil content.

Question 7

how are some ways you evaluate lbdds?

Answer 7

1. dispersability- not official method yet.
2. viscosity and rheological measurements. (improves accuracy of partical measurement)
3. zeta potential. (useful indicator of stability of the dispersed sample.)
4. conductivity - structure of emulsion formed on dispersion.

Question 8

How do lipid-based drug delivery systems enhance drug absorption?

Answer 8

LBDDS promotes drug solubilization within the GI tract, facilitates lymphatic transport, and bypasses first-pass metabolism, improving systemic bioavailability.

Question 9

What types of drugs are commonly formulated with LBDDS?

Answer 9

Drugs with poor water solubility and low oral bioavailability, such as certain antifungals, antivirals, and anticancer agents.

Question 10

What is a significant challenge in developing LBDDS?

Answer 10

Stability issues, potential GI irritation from high surfactant content, and formulation complexity.

Question 11

What is the primary route of administration for LBDDS?

Answer 11

Oral administration, though LBDDS can also be adapted for parenteral, topical, and inhalational routes.

Question 12

What factors impact the effectiveness of lipid-based drug delivery systems?

Answer 12

Lipid composition, particle size, surfactant type, and drug-lipid compatibility all influence the performance of LBDDS.