lipid based drug delivery systems Flashcards
briefly explain the four classes of LBDDS
class 1. g solubility, g permeability
class 2. b solubility, g permeability
class 3. opposite.
class 4. neither good
What are the main benefits of lipid-based drug delivery systems?
- LBDDS can improve drug solubility
- enhance bioavailability
- protect drugs from degradation
- offer controlled release.
explain the components of a LBDDS
- the lipid (oils etc)
- a surfactant. (amphipathic molecules.)
- a co-solvent (low molecular weigh alcohols, propylene glycol_)
how would u make a lbdds
- a simple mixing (heat, sonication, particle size reduction.)
- put in a soft or hard gelatine capsule.
- a formulation process. ( drug plus oil, surfactant etc.)
key advantage of LFCS Type 2 formulations
Unlikely to lose solvent capacity on dispersion
What are the characteristic features of LFCS Types 1 through 4?
- Type I: Simple oils, no surfactants, low drug-loading capacity.
- Type II: Self-emulsifying formulations with oils and surfactants.
- Type III: Self-microemulsifying with higher surfactant content.
- Type IV: High surfactant and co-surfactant, very low oil content.
how are some ways you evaluate lbdds?
- dispersability- not official method yet.
- viscosity and rheological measurements. (improves accuracy of partical measurement)
- zeta potential. (useful indicator of stability of the dispersed sample.)
- conductivity - structure of emulsion formed on dispersion.
How do lipid-based drug delivery systems enhance drug absorption?
- LBDDS promotes drug solubilization within the GI tract
- facilitates lymphatic transport
- bypasses first-pass metabolism, improving systemic bioavailability.
What types of drugs are commonly formulated with LBDDS?
Drugs with poor water solubility and low oral bioavailability, such as certain antifungals, antivirals, and anticancer agents.
What is a significant challenge in developing LBDDS?
- Stability issues
- potential GI irritation from high surfactant content
- formulation complexity.
What is the primary route of administration for LBDDS?
Oral administration, though LBDDS can also be adapted for parenteral, topical, and inhalational routes.
What factors impact the effectiveness of lipid-based drug delivery systems?
- Lipid composition
- particle size
- surfactant type
- drug-lipid compatibility all influence the performance of LBDDS.