orodispersible tablets

Question 1

What is the aim of orodispersible technology in therapeutic delivery?

Answer 1

To develop dosage forms that disperse in the mouth, providing ease of administration and rapid onset of action.

Question 2

Which ODT is commonly used for nausea and vomiting caused by chemotherapy or radiotherapy?

Answer 2

Ondansetron (Zofran).

Question 3

what are some ideal characteristics for an ODT

Answer 3

1. rapid disintegration
2. good mechanical strength
3. appropriate tablet size
4. stable.
5. minimal residue in oral cavity.
6. low cost

Question 4

list some limitations of ODT

Answer 4

1. drug loading
2. taste masking
3. limitation of drug choice
4. advanced delivery systems
5. bioequivalence

Question 5

explain and give examples of each method used for making odt’s

Answer 5

1. lyophilisation - Freeze drying of solution or suspension with sugar alcohols (mannitol) and structure formers
   - Zydis
2. direct compression - Using low compression forces to create softer tablets. With excipients that swell / melt at 37°C / effervesce / rapidly dissolve.
   - calpol meltlets
3. fast dissolving films - Polymers dissolved in solvent and reformed as a thin film (PVP, HPMC etc). Film must be flexible and not brittle.
   -Niquitin