Pulmonology Flashcards
DDX for hemoptysis
Bronchiectasis Acute bronchitis Lung carcinoma Tuberculosis PE Foreign body aspiration
DDX for pleuritic chest pain
Bronchiectasis Costochondritis Pleural effusion Pneumothorax Pulmonary embolism Pneumonia Tuberculosis
Acute bronchitis often follows
URI
Acute bronchitis is most commonly caused by
Viruses
Adenovirus
Parainfluenza, influenza, coxsackie, rhinovirus
Diagnosis of acute bronchitis
Usually clinical w/o need for imaging
If suspect pneumonia - order CXR
CXR will be normal or nonspecific
Management of acute bronchitis
Symptomatic - fluids, rest, +/- bronchodilators, +/- antitussives
Antibiotics no statistical benefit in healthy pts
Lower respiratory tract infection of the small airways leading to mucus plugging and peripheral airway narrowing and variable obstruction
RSV - Acute bronchiolitis
Most common cause of acute bronchiolitis
RSV - respiratory syncytial virus
Most common age group affected by RSV
< 6 mo (esp ~ 2 mo)
Risk factors for RSV
Cigarette exposure
Lack of breastfeeding
Premature
Crowded conditions
Complications of RSV
Otitis media - most common acute
Asthma - most common later in life
Fever, URI symptoms for 1-2 days followed by respiratory distress (wheezing, tachypnea, nasal flaring, cyanosis, retractions)
RSV - acute bronchiolitis
Diagnosis of RSV/acute bronchiolitis
CXR - hyperinflation, peribronchial cuffing
Nasal washings using monoclonal Ab testing
Pulse ox
Best predictor of disease in children with RSV
Pulse ox
< 96% - admit
Management of RSV
Supportive: O2 mainstay
Albuterol, racemic epi if albuterol not effective
Ribavirin if severe
Prevention of RSV
Palivizumab prophylaxis in high risk groups
Hand washing preventative!
Mortality from acute epiglottitis is usually secondary to
Asphyxiation
Most common cause of acute epiglottitis
Haemophilus influenza type B
Reduced incidence due to Hib vaccination
Strept pneumonia, S. aureus, GABHS
Epidemiology of acute epiglottitis
3 mo - 6 years
Males 2X more common
3 D’s: dysphagia, drooling, distress
Acute epiglottitis
Inspiratory stridor, dyspnea, hoarseness, tripoding
Acute epiglottitis
Suspect in pt with rapidly developing pharyngitis, muffled voice and odynophagia out of proportion to physical findings
Acute epiglottitis
Diagnosis of acute epiglottitis
- Laryngoscopy - definitive diagnosis - cherry red epiglottis with swelling
- Lateral cervical radiograph - thumb sign
Management of acute epiglottitis
- Airway management - dexamethasone, intubation if severe
- Abx - ceftriaxone or cefotaxime
- +/- add penicillin, ampicillin
Inflammation most commonly secondary to acute viral infxn of the upper airway leading to subglottic larynx/trachea swelling
Laryngotracheitis (croup)
Signs/symptoms of Laryngotracheitis (croup)
- Barking cough (seal-like, harsh)
- Stridor (both inspiratory and expiratory)
- Hoarseness
- Dyspnea (especially worse at night)
- +/- preceding URI sx
Diagnosis of laryngotracheitis (croup)
- Clinical
2. Frontal cervical radiograph - steeple sign
Steeple Sign
Laryngotracheitis (croup)
Management of mild croup (no stridor at rest, no respiratory distress)
Cool humidified air mist, hydration
Dexamethasone
Supplemental O2 if < 92%
Management of moderate croup (stridor at rest with mild-mod retractions)
Dexamethasone PO or IM
+/- nebulized epinephrine
Should be observed 3-4 hrs
Management of severe croup (stridor at rest with marked retractions)
Dexamethasone + nebulized epinephrine and hospitalization
Highly contagious infection secondary to bordetella bacteria
Pertussis (Whooping Cough)
Signs/Symptoms of pertussis (whooping cough)
Catarrhal Phase - URI
Paroxysmal Phase
Convalescent Phase
Inspiratory whooping sounds after coughing fits
Paroxysmal Phase of pertussis (whooping cough)
The convalescent phase of pertussis may last for up to
6 weeks
Diagnosis of pertussis (whooping cough)
PCR of nasopharyngeal swab - gold standard
Lymphocytosis - elevated lymphocytes and WBC
Management of pertussis (whooping cough)
- Supportive (oxygen, nebulizers)
2. Erythromycin, Azithromycin (Bactrim if PCN allergic)
Complications of pertussis (whooping cough)
Pneumonia Encephalopathy Otitis media Sinusitis Seizures
Most common cause of CAP
Streptococcus pneumoniae
Haemophilus influenzae
Klebsiella pneumonia is seen in ________ and is associated with _________
Alcoholics
Cavitary lesions
Most common viral cause of pneumonia in infants/small children
RSV
Parainfluenza
Most common viral cause of pneumonia in adults
Influenza
Most common causes of hospital acquired pneumonia
Pseudomonas
E coli
Klebsiella
S. aureus (MRSA)
When to hospitalize for pneumonia
- Multilobar
- Neutropenia
- Comorbidities
Still considered community acquired if pt develops pneumonia within ___________ of initial hospital admission
48 hours
Physical exam signs of pneumonia
Dullness on percussion
Egophony
Increased tactile fremitus
Inspiratory rales (crackles)
Mycoplasma pneumonia (atypical) is associated with:
bullous myringitis
Legionella pneumonia is associated with
GI symptoms
Increased LFTs
Diagnosis of pneumonia
- CXR/CT
2. Sputum (Gram stain/culture)
Rusty (blood-tinged) sputum in pneumonia
Step pneumoniae
Currant jelly sputum in pneumonia
Klebsiella
Management of CAP outpatient
Macrolide or Doxycycline
Management of CAP inpatient
B lactam + macrolide or doxycycline
OR fluoroquinolone
Management of HAP
B lactam + AG or FQ
Reverse hyperirritability of the tracheobronchial tree, leading to airway inflammation and bronchoconstriction
Asthma
Most common chronic childhood disease
Asthma
Samter’s Triad
- Asthma
- Nasal polyps
- ASA/NSAID allergy
Classic triad of asthma
- Dyspnea
- Wheezing
- Coughing (esp at night)
Prolonged expiration with wheezing, hyperresonance to percussion
Asthma
Diagnosis of asthma
- PFT - gold standard (reversible obstruction)
- Bronchoprovocation - methacholine challenge
- Peak Flow Rate - best for assessing severity
- Pulse Ox
- ABG
- CXR
Admission criteria for asthma
PEFR < 50% predicted Er visit within 3 days of exacerbation Status asthmaticus Post treatment failure AMS
Adjuncts for asthma management
IV magnesium - indicated in severe asthma
Omalizumab - used in severe, uncontrolled asthma
Abnormal accumulation of fluid in the pleural space (not a disease itself but a sign of a disease)
Pleural effusion
Grossly purulent/turbulent effusion (direct infection of the pleural space)
Empyema
Circulatory system fluid in pleural effusion due to either increased hydrostatic and/or decreased oncotic pressure
Transudative fluid
Most common causes of transudative pleural effusion
CHF
Nephrotic syndrome
Cirrhosis
Occurs when local factors within the lungs themselves cause a pleural effusion by increasing vascular permeability
Exudative fluid
Signs/symptoms of pleural effusion
Typically asymptomatic
If symptomatic: dyspnea, pleuritic chest pain, cough
Physical exam with pleural effusion
Decreased breath sounds
Decreased tactile fremitus
Dullness to percussion
+/- pleural friction rub
Diagnosis of pleural effusion
- CXR - PA/lateral, lateral decubitus best
- Thoracentesis - test of choice - send fluid for culture, chemistry, cell count, cytology
- CT scan - used to determine empyema
Light’s Criteria:
Pleural Effusion
Presence of any criteria determines exudative fluid
Management of pleural effusion
- Treat underlying condition
- Thoracentesis - gold standard
- Chest tube pleural fluid drainage (if empyema)
- Pleurodesis - if malignant effusions or chronic
Accumulation of air in the pleural space
Pneumothorax
Risk factors for spontaneous pneumothorax
- Family history
- Smoking
- Males
Diagnosis of pneumothorax
CXR
Treatment for spontaneous pneumothorax
Small - oxygenation and observation - repeat CXR after 6 hours
Large - pleural aspiration, chest tube
Unstable - chest tube
Treatment for tension pneumothorax
Immediate needle decompression and chest tube
Thrombus in the pulmonary artery or its branches - not a disease itself but a complication of a DVT
Pulmonary embolism
Most people who die from PE die from:
Subsequent PEs (not initial one)
Most common signs/symptoms of PE
Dyspnea, tachypnea
Pleuritic chest pain
Most common predisposing condition for PE
Factor V Leiden
Diagnosis for PE
- Helical CT scan - best initial test
- V/Q scan
- Pulmonary angiography - gold standard
- Doppler US - 70% of pts with PE will be positive for lower extremity DVT
A normal CXR in the setting of hypoxia is highly suspicious for
Pulmonary embolism
Westermark’s Sign
Pulmonary embolism on CXR
Hampton’s Hump
Pulmonary embolism on CXR
Most specific result for PE on EKG
S1Q3T3
Simple lab test to r/o PE if low
D-dimer
Management of Pulmonary embolism
LMWH - low risk pts Warfarin for at least 3 mo May use dabigatran or apixaban instead IVC filter if anticoag CI or failed Thrombolysis of clot - streptokinase Thrombectomy/Embolectomy - unstable/massive PE if thrombolysis ineffective
Life threatening acute hypoxemic respiratory failure (organ failure from prolonged hypoxemia)
Acute respiratory distress syndrome
Most common cause of ARDS
Sepsis
Severe trauma
Aspiration of gastric contents
Signs/Symptoms of ARDS
acute dyspnea and hypoxemia
Multi-organ failure if severe
Diagnosis of ARDS
- Severe refractory hypoxemia (HALLMARK)
- Bilateral pulmonary infiltrates on CXR
- Absence of cardiogenic pulmonary edema/CHF
Pulmonary Capillary Wedge Pressure that is < _________ is indicative of ARDS as opposed to cardiogenic pulmonary edema
18 mmHg
If > 18 mmHg, points towards cardiogenic pulmonary edema
Management of ARDS
Noninvasive or mechanical ventilation and treat underlying cause
Diagnosis of foreign body aspiration
- Bronchoscopy - allows for removal
2. CXR
Chronic infection leading to granuloma formation
Tuberculosis
High risk populations for TB
Healthcare workers Homeless Immigrants Immunodeficiency Incarcerated
Diagnosis of tuberculosis
- Acid-Fast Smear and Sputum Culture x 3 days
- CXR
- Interferon Gamma Release Asay
Treatment for Active TB infection
RIPE Rifampin INH Pyrazinamide Ethambutol
S/E of rifampin
Thrombocytopenia, orange colored secretions
S/E of isoniazid
Hepatitis
Peripheral neuropathy
Drug-induced lupus
S/E of pyrazinamide
Hepatitis
Hyperuricemia
Photosensitive dermatologic rash
S/E of ethambutol
Optic neuritis, peripheral neuropathy
Treatment of latent TB infection
INH + pyridoxine x 9 mo
Most common cause of cancer death in the world
Lung cancer
90% of lung cancer cases are associated with
Cigarette smoking
Most common type of lung cancer
Non-small cell carcinoma (75%)
Most common type of non-small cell carcinoma
Adenocarcinoma
Screening for lung cancer
> 55 y/o
30 pack year smoker
Must have smoked in last 15 years
Screen annually until 80 or if person has not smoked in 15 years
Diagnosis of lung cancer
- CXR
- Chest CT
- Biopsy
Treatment for small cell carcinoma lung cancer
Chemo and radiation
Very poor prognosis
Treatment for non-small cell carcinoma lung cancer
Surgical resection with or without chemo
If mass is resectable but pt has poor pulmonary fxn, not a candidate for surgery