Dermatology Flashcards
Atopic disease triad
- Eczema
- Allergic rhinitis
- Asthma
Starts in childhood
Altered immune reaction in genetically susceptible people when exposed to certain triggers. T cell mediated immune activation and increased IgE production
Dermatitis (Eczema)
Hallmark of eczema
Pruritus
Erythematous, ill-defined blisters/papules/plaques that later dries, crusts over and scales
Dermatitis (Eczema)
Dermatitis (eczema) is most commonly seen on the
Flexor creases - antecubital and popliteal folds
Localized development of hives when the skin is stroked
Dermatographism
Management of dermatitis (eczema)
- Topical corticosteroids
2. Antihistamines for itching
Burning, itching, and erythema to the affected area, dry skin, eczematous eruption
Contact dermatitis
Tx for contact dermatitis
- Topical corticosteroids
2. Antihistamines for itching
Most common drug eruption
Exanthematous/Morbilliform rash
Generalized distribution of “bright-red” macules and papules that coalesce to form plaques, typically begins 2-14 days after medication initiation
Exanthematous/Morbilliform rash
Most common causes of Exanthematous/Morbilliform rash
NSAIDs
Antibiotics
Allopurinol
Thiazide diuretics
2nd most common type of drug eruption
Urticaria
Most common causes of urticarial drug eruption
antibiotics
NSAIDs
Opiates
Radiocontrast media
Third most common causes of drug eruption
Erythema multiforme
Most common causes of erythema multiforme
Sulfonamides
Penicillins
Phenobarbital
Management of exanthematous/morbilliform drug eruption
Oral antihistamines
Management of drug induced urticaria
Systemic corticosteroids
Antihistamines
Management of erythema multiforme
Symptomatic therapy
Topical steroids, oral antihistamines
Management of anaphylaxis
IM epi
Most common causes of SJS/TEN
Allopurinol Sulfonamides Lamotrigine NSAIDs Anticonvulsants
Second most common causes of SJS/TEN
Mycoplasma pneumonia
Cytomegalovirus
SJS affects _____ of total body surface area
< 10%
TEN affects ____ of total body surface area
> 30%
Gentle pressure to the skin causes sloughing
Nikolsky sign
SJS/TEN
Treatment for SJS/TEN
Admit to hospital, preferably to burn unit
Supportive care is mainstay of tx
Pts with SJS/TEN are at very high risk for
respiratory failure
Sepsis and shock secondary to infection
Chronic widespread autoimmune blistering skin disease primarily of the elderly
Bullous pemphigoid
Bullous pemphigoid will have a _____ Nikolsky sign
Absent
Management of bullous pemphigoid
Systemic corticosteroids
Antihistamines for itching
Immunosuppressants (Azathioprine)
Topical corticosteroids if mild
Management of lice
- Permethrin topical drug of choice
Shampoo or lotion
Safe in children > 2 y/o - Lindane second line
do not use after showering (neurotoxic)
Instructions for mom - kid with lice
Bedding/clothing should be laundered in hot water with detergents and dried in hot drier for 20 minutes. Toys that cannot be washed should be placed in airtight plastic bags x 14 days.
Intensely pruritic lesions, linear burrows that are commonly found in the intertriginous zones including web spaces between fingers/toes, scalp
Scabies
Diagnosis of scabies
Often clinical
Skin scraping of the burrows with mineral oil to identify mites or eggs under microscopy
Management of scabies
- Permethrin topical
Apply x1, then x 1 week later - Lindane (cheaper)
Do not use after showering
Instructions for pt with scabies
All clothing, bedding, etc. should be placed in a plastic bag at least 72 hrs then washed and dried using heat
Erythematous margin around ischemic center (“red halo”)
Brown recluse spider bites
Management of brown recluse spider bites
- Local wound care - cold packs, keep affected body part elevated
- Pain control
- Tetanus
- Dermal necrosis - debridement
Classic appearance is a blanched circular patch with a surrounding red perimeter and central punctum (target lesion)
Black widow spider bite
Management of black widow spider bite
- Mild: wound care - clean with soap and water, NSAIDs
2. Mod-Severe: opioids +/- muscle relaxants
Prodrome of high fever 3-5 days, leading to rose, pink, maculopapular, blanchable rash on the trunk/back, then to the face
Roseola Infantum (6th disease)
Only childhood exanthema that starts on trunk and spreads to face
Roseola infantum (6th disease)
Mild fever, URI sx, decreased appetite starting 3-5 days after exposure, leading to vesicular lesions with erythematous halos in the oral cavity
Hand Foot and Mouth Disease
Management for hand/foot/mouth dz
Supportive - antipyretics, topical lidocaine
Rashes that affect palms/soles
Coxsackie (HF&M)
RMSF
Syphilis (secondary)
Janeway lesions
Low grade fever, myalgias, headache, parotid gland pain and swelling
Mumps
Management of mumps
Supportive
Anti inflammatories
Complications of mumps
Orchitis in males
Most common cause of acute pancreatitis in children
URI prodrome of the 3 C’s and high fever, followed by koplik spots and morbilliform rash on face beginning and hairline going to extremities
Cough, coryza, conjunctivitis
Rubeola (Measles)
Small red spots in buccal mucosa with pale blue/white center precedes rash by 24-48 hours, lasts 2-3 days
Koplik spots
Rubeola (Measles)
Rubeola (measles) usually lasts __________
7 days - fades from top to bottom
____________ reduces mortality in all children with measles (Rubeola)
Vitamin A
Complications of rubeola (measles)
Diarrhea Otitis media Pneumonia conjunctivitis Encephalitis
3 day rash
Rubella (German measles)
Low grade fever, cough, anorexia, lymphadenopathy (posterior cervical, posterior auricular), followed by pink, light-red spotted maculopapular rash on face spreading to extremities
Rubella (German measles)
Small red macules or petechiae on soft palate
Forchheimer Spots
Seen with Rubella (German measles)
Diagnosis of german measles
Rubella-specific IgM antibody via enzyme immunoassay
Rubella (german measles) is ____________, especially in the ______________
Teratogenic
First trimester
Sensorineural deafness, cataracts, TTP (blueberry muffin rash), mental retardation, heart defects
Coryza, fever, slapped cheek rash on face with circumoral pallor 2-4 days, lacy reticular rash on extremities
Erythema infectiosum (Fifth disease)
Virus that causes erythema infectiosum (fifth disease)
Parvovirus B19
The virus that causes erythema infectiosum (fifth disease) is known to cause ____________ in pts with __________ or ____________
Aplastic crisis
Sickle cell disease
G6PD deficiency
Clusters of vesicles on an erythematous base “dew drops on a rose petal” in different stages (macules, papules, vesicles, pustules and crusted lesions) beginning on face/trunk spreading to extremities
Varicella (chicken pox)
Shingles involving first division of the trigeminal nerve
Herpes Zoster Ophthalmicus
Lesions on the nose usually heralding ocular involvement with varicella
Hutchinson’s Sign
_______ ________ usually seen on slit lamp with herpes zoster ophthalmicus
Dendritic lesions
Facial nerve palsy, otalgia, lesions on the ear, auditory canal and tympanic membrane, auditory sx (tinnitus, vertigo, deafness, ataxia)
Herpes Zoster Oticus (Ramsay-Hunt Syndrome)
Pain > 3 months after initial shingles development, hyperesthesias or decreased sensation
Post Herpetic Neuralgia
Treatment of herpes zoster (shingles)
Acyclovir, Valacyclovir, Famciclovir
Gabapentin
Prednisone
Hydrocodone
Treatment of herpes zoster ophthalmicus
PO antivirals
Treatment of ramsey hunt syndrome
Oral acyclovir plus corticosteroids
Treatment of post herpetic neuralgia
Gabapentin or tricyclic antidepressants, topical lidocaine gel
Raised with clear line of demarcation between infected and uninfected tissue
Erysipelas
Treatment of cellulitis with drainage
Treat for MRSA
Clindamycin, TMP/SMX, doxycycline
Treatment for cellulitis without drainage
Clindamycin, Cephalexin, Dicloxacillin
Treatment for erysipelas
Penicillin, macrolide, cephalexin, clindamycin
Highly contagious superficial vesiculopustular skin infection
Impetigo
Impetigo occurs typically at sits of superficial _____________ primarily on exposed surfaces of the face and extremities
Skin trauma (insect bites)
Risk factors for impetigo
Warm, humid conditions
Poor personal hygiene
Most common causes of impetigo
Staph aureus
GABHS
Management of impetigo
Mupirocin (Bactroban) topical TID x 10 days
Bacitracin
Good skin hygiene
Management of impetigo with extensive disease of systemic symptoms (ex. fever)
Systemic antibiotics (Cephalexin, Dicloxacillin, clindamycin, erythromycin, azithromycin)
Tender abscess with drainage on or near the gluteal cleft near the midline of the coccyx or sacrum with small midline pits
Pilonidal disease
Management of pilonidal disease
Incision and drainage - excision of pilonidal sinus and tracts recommended if recurrent
Skin intact, superficial, nonblanchable redness that does not dissipate after pressure is relieved
Stage I pressure sore
Epidermal damage extending into the dermis. Shallow ulcer that resembles a blister or abrasion
Stage II pressure sore
Full thickness of the skin and may extend into the subcutaneous layer
Stage III pressure sore
Deepest, extends beyond the fascia, into the muscle, tendon or bone
Stage IV pressure sore