Dermatology Flashcards
Atopic disease triad
- Eczema
- Allergic rhinitis
- Asthma
Starts in childhood
Altered immune reaction in genetically susceptible people when exposed to certain triggers. T cell mediated immune activation and increased IgE production
Dermatitis (Eczema)
Hallmark of eczema
Pruritus
Erythematous, ill-defined blisters/papules/plaques that later dries, crusts over and scales
Dermatitis (Eczema)
Dermatitis (eczema) is most commonly seen on the
Flexor creases - antecubital and popliteal folds
Localized development of hives when the skin is stroked
Dermatographism
Management of dermatitis (eczema)
- Topical corticosteroids
2. Antihistamines for itching
Burning, itching, and erythema to the affected area, dry skin, eczematous eruption
Contact dermatitis
Tx for contact dermatitis
- Topical corticosteroids
2. Antihistamines for itching
Most common drug eruption
Exanthematous/Morbilliform rash
Generalized distribution of “bright-red” macules and papules that coalesce to form plaques, typically begins 2-14 days after medication initiation
Exanthematous/Morbilliform rash
Most common causes of Exanthematous/Morbilliform rash
NSAIDs
Antibiotics
Allopurinol
Thiazide diuretics
2nd most common type of drug eruption
Urticaria
Most common causes of urticarial drug eruption
antibiotics
NSAIDs
Opiates
Radiocontrast media
Third most common causes of drug eruption
Erythema multiforme
Most common causes of erythema multiforme
Sulfonamides
Penicillins
Phenobarbital
Management of exanthematous/morbilliform drug eruption
Oral antihistamines
Management of drug induced urticaria
Systemic corticosteroids
Antihistamines
Management of erythema multiforme
Symptomatic therapy
Topical steroids, oral antihistamines
Management of anaphylaxis
IM epi
Most common causes of SJS/TEN
Allopurinol Sulfonamides Lamotrigine NSAIDs Anticonvulsants
Second most common causes of SJS/TEN
Mycoplasma pneumonia
Cytomegalovirus
SJS affects _____ of total body surface area
< 10%
TEN affects ____ of total body surface area
> 30%
Gentle pressure to the skin causes sloughing
Nikolsky sign
SJS/TEN
Treatment for SJS/TEN
Admit to hospital, preferably to burn unit
Supportive care is mainstay of tx
Pts with SJS/TEN are at very high risk for
respiratory failure
Sepsis and shock secondary to infection
Chronic widespread autoimmune blistering skin disease primarily of the elderly
Bullous pemphigoid
Bullous pemphigoid will have a _____ Nikolsky sign
Absent
Management of bullous pemphigoid
Systemic corticosteroids
Antihistamines for itching
Immunosuppressants (Azathioprine)
Topical corticosteroids if mild
Management of lice
- Permethrin topical drug of choice
Shampoo or lotion
Safe in children > 2 y/o - Lindane second line
do not use after showering (neurotoxic)
Instructions for mom - kid with lice
Bedding/clothing should be laundered in hot water with detergents and dried in hot drier for 20 minutes. Toys that cannot be washed should be placed in airtight plastic bags x 14 days.
Intensely pruritic lesions, linear burrows that are commonly found in the intertriginous zones including web spaces between fingers/toes, scalp
Scabies
Diagnosis of scabies
Often clinical
Skin scraping of the burrows with mineral oil to identify mites or eggs under microscopy