Gynecology Flashcards
Painful menstruation that affects normal activities
Dysmenorrhea
Primary dysmenorrhea is not due to ________ but is due to increased ___________
Not due to pelvic pathology
Due to increased prostaglandins
Painful uterine muscle wall activity
Secondary dysmenorrhea is due to __________, such as
Pelvic pathology Endometriosis Adenomyosis Leiomyomas Adhesions PID
Most common secondary cause of dysmenorrhea in younger patients. Most common secondary cause of dysmenorrhea in older pts
Endometriosis - younger
Adenomyosis - older
Diffuse pelvic pain right before or with onset of menses. May be associated with HA, n/v. Cramps usually last 1-3 days
Dysmenorrhea
Management of dysmenorrhea
NSAIDs first line
Local heat and vitamin E
Ovulation suppression - OCPs, etc.
Laparoscopy if medication fails to ro secondary causes
Absence of menstrual periodd
Amenorrhea
Light flow or spotting
Cryptomenorrhea
Heavy or prolonged bleeding at normal menstrual intervals
Menorrhagia
Irregular bleeding between expected menstrual cycles
Metorrhagia
Irregular, excessive bleeding between expected menstrual cycles
Menometrorrhagia
Infrequent menstruation with a prolonged cycle length > 35 days but < 6 mo
Oligomenorrhea
Frequency cycle interval (< 21 days)
Polymenorrhagia
Two etiologies of dysfunctional uterine bleeding (DUB)
- Chronic anovulation
2. Ovulatory
Cause of chronic anovulation
Unopposed estrogen
Seen especially with extremes of age
Workup of dysfunctional uterine bleeding includes:
- pelvic exam
- Hormone levels
- Transvaginal US
Management of acute severe bleeding with DUB
High dose IV estrogens or high dose OCPs
Management of anovulatory DUB
OCPs first line
Progesterone if estrogen CI
Definitive treatment for DUB
Hysterectomy - done if not responsive to medical treatment
Endometrial ablation - can be done if hysterectomy not wanted
Workup for amenorrhea
Pregnancy test
Serum prolactin
FSH, LH, TSH
Primary amenorrhea
Failure of menarche onset by age 15 y/o in the presence of secondary sex characteristics or 13 y/o in the absence of secondary sex characteristics
Secondary amenorrhea
Absence of menses for > 3 months in a pt with previously normal menstruction
Etiologies of secondary amenorreha
- Pregnancy (MC)
- Hypothalamus dysfunction
- Pituitary dysfunction
- Ovarian dysfunction
- Uterine disorder
Presence of endometrial tissue (stroma and gland) outside the endometrial (uterine) cavity. The ectopic endometrial tissue responds to cyclical hormonal changes
Endometriosis
Most common site for endometriosis
Ovaries
Also: posterior cul de sac, broad and uterosacral ligaments, rectosigmoid colon, bladder
Risk factors for endometriosis
Nulliparity
Family history
Early menarche
Signs/Symptoms of endometriosis
- Cyclic premenstrual pelvic pain
- Dysmenorrhea (painful menstruation)
- Dyspareunia (painful intercourse)
- Infertility
+/- low back pain
Diagnosis of endometriosis
Physical exam: normal, +/- fixed tender adnexal masses
Laparoscopy with biopsy - definitive treatment
Endometriosis involving the ovaries large enough to be considered a tumor, usually filled with old blood appearing chocolate-colored
Endometrioma (chocolate cyst)
Management of endometriosis
- Medical - ovulation suppression
OCPs + NSAIDs as needed
Leuprolide
Danazol (testosterone) - Surgical - laparoscopy with ablation or hysterectomy if no desire to conceive
Occur when follicles fail to rupture and continue to grow
Follicular ovarian cysts
Occurs when corpus luteum fails to degenerate after ovulation
Corpus luteal ovarian cysts
Excess hCG causes hyperplasia of the theca interna cells
Theca Lutein ovarian cyst
Signs/symptoms of ovarian cysts
Most are asymptomatic until they rupture, undergo torsion or become hemorrhagic
Menstrual changes, dyspareunia
Diagnosis of ovarian cysts
Pelvic US
Order hCG to r/o pregnancy
Smooth, thin-walled unilocular ovarian cyst on ultrasound
Follicular
Complex, thicker-walled with peripheral vascularity ovarian cyst on ultrasound
Luteal
Management of ovarian cysts
Most < 8 cm are functional and spontaneously resolve
NSAIDs, repeat US after 6 weeks
OCPs
Surgical intervention if > 8 cm or cysts found postmenopause
Two etiologies of vaginitis
- Infectious (bacterial, trichomoniasis, candida, cytolytic)
- Atrophic (postmenopausal, allergic rxn)
Copious discharge, watery grey-white “fish rotten” smell from vagina
Bacterial vaginosis
Malodorous discharge, frothy yellow green vaginal discharge, strawberry cervix
Trichomoniasis vaginosis
Thick curd-like/cottage cheese vaginal discharge
Candidiasis vaginosis
Non odorous vaginal discharge that is white to opaque
Cytolytic vaginosis
Diagnosis of bacterial vaginosis
Whiff test (fishy odor) Microscopic: epithelial cells covered with bacteria
Diagnosis of trichomoniasis vaginosis
Mobile protozoa on wet mount, WBCs
Diagnosis of candidiasis vaginosis
Hyphae, yeast and spores on KOH prep
Diagnosis of cytolytic vaginosis
Copious lactobacilli, large number of epithelial cells
Management of:
- Bacterial vaginosis
- Trichomoniasis
- Candidiasis vaginosis
- Cytolytic vaginosis
- Metronidazole or Clindamycin
- Metronidazole or Tinidazole
- Fluconazole, intravaginal antifungals
- Discontinue tampon usage, sodium bicarbonate (sitz baths)
Ascending infection of the upper reproductive tract (may lead to sepsis, ectopic pregnancy or infertility)
Pelvic inflammatory disease
Most common causes of PID
N gonorrhea
Chlamydia
People at increased risk of PID
Multiple sex partners Unprotected sex Prior PID Age 15-29 Nulliparous IUD placement
Pelvic/lower abdominal pain, dysuria, dyspareunia, vaginal discharge, nausea, vomiting
PID
Lower abdominal tenderness, fever. Purulent cervical discharge, +/- bleeding
PID
Cervical motion tenderness to palpation and rotation so severe they seem to rise off the bed
Chandelier sign
PID
Diagnosis of PID
- Primarily clinical
- Obtain hCG to r/o pregnancy
- Gram stain, WBC > 10,000
- Pelvic ultrasound if abscess suspected
- Laparoscopy if uncertain, severe disease or if no improvement with antibiotics
Management of outpatient PID
Doxycycline + IM ceftriaxone
Management of inpatient PID
IV doxycycline + cefoxitin or cefotetan
Complications of pelvic inflammatory disease
Fitz-Hugh Curtis Syndrome Infertility Tubo-obarian abscess Ectopic pregnancy Chronic pelvic pain
Hepatic fibrosis/scarring and peritoneal involvement. RUQ pain due to perihepatitis. May radiate to right shoulder. Often have normal LFTs. Violin string adhesions on anterior liver surface
Fitz-Hugh Curtis Syndrome
Complication of PID
Inflammation of the breast
Mastitis
Seen mostly in lactating women secondary to nipple trauma
Infectious mastitis
Most common bacterial etiologies of infective mastitis
Staph aureus
Strep
+/- Candida
Signs/Symptoms of infective mastitis
Unilateral breast pain Tenderness Warmth Swelling Nipple discharge
Signs/Symptoms of congestive mastitis
Bilateral breast pain and swelling
Low grade fever
Axillary lymphadenopathy
Management of infective mastitis
Supportive measures (warm compresses, breast pump)
Anti-staphylococcal abx: Dicloxacillin, nafcilllin, cephalosporin
Fluconazole if fungal
Mothers may continue to nurse/breast pump
Management of congestive mastitis
If woman does not want to breastfeed: ice packs, tight fitting bras, analgesics, avoid breast stimulation
If women wants to breastfeed, manually empty breast after baby is done, local heat, analgesics
Management of breast abscess
I&D
Discontinue breastfeeding from affected breast
Termination of pregnancy before __________ is classified as spontaneous abortion. Most commonly during first ________ weeks.
20 weeks
7 weeks
__________ is the only type of spontaneous abortion that is associated with possible fetal viability
Threatened
Most common cause (50%) of all cases of spontaneous abortion
Fetal chromosomal abnormalities
Most common cause of first trimester bleeding
Threatened spontaneous abortion
Signs/symptoms of threatened spontaneous aboriton
No products of conception expelled
Cervical os is closed
Bloody vaginal discharge, spotting progressing to profuse blood
Signs/symptoms of inevitable spontaneous abortion
No products of conception expelled
Progressive cervix dilation > 3 cm
+/- rupture of membranes
Moderate bleeding > 7 days, cramping
Signs/symptoms of incomplete spontaneous abortion
Some products of conception expelled, some retained
Cervical os dilated
Heavy bleeding, cramping, boggy uterus
Signs/symptoms of missed spontaneous abortion
No products of conception expelled
Cervical os closed
Loss of pregnancy symptoms, +/- brown discharge
Signs/symptoms of septic spontaneous abortion
Cervical os closed
Cervical motion tenderness
Foul brownish discharge, fevers, chills, uterine tenderness, spotting progressing to heavy bleeding
Abruptio placenta is premature separation of the placenta from the uterine wall after __________ gestation
20 weeks
Signs/symptoms of abruptio placenta
Mild: slight bleeding
Partial: moderate bleeding
Complete: heavy bleeding and increased risk to fetus and mother
Severe abdominal pain, painful contractions, rigid uterus
Fetal signs during abruptio placenta
Fetal bradycardia - fetal distress due to interference with fetal oxygenation
Diagnosis of abruptio placenta
Pelvic ultrasound
DO NOT perform pelvic exam
Management of abruptio placenta
Hospitalization - for hemodynamic stabilization
Immediate delivery - C section preferred
Complications of abruptio placenta
May lead to DIC (disseminated intravascular coagulation)
Risk factors for abruptio placenta
Maternal HTN (MC) Smoking EtOH Cocaine Increased age, trauma
Implantation of fertilized ovum outside of the uterine cavity
Ectopic pregnancy
Most common location of ectopic pregnancy
Fallopian tube (98%)
Risk factors for ectopic pregnancy
Previous abdominal or tubal surgery (due to adhesions) PID Previous ectopic History of tubal ligation Endometriosis
Signs/Symptoms of ectopic pregnancy
Unilateral pelvic/abdominal pain
Vaginal bleeding
Amenorrhea (pregnancy)
Severe abdominal/shoulder pain (peritonitis)
Signs/Symptoms of ruptured ectopic pregnancy
Severe abdominal pain, dizziness, nausea, vomiting
Signs of shock: syncope, tachycardia, hypotension
Physical exam signs of ectopic pregnancy
Cervical motion tenderness
Adnexal mass
Mild uterine enlargement
Diagnosis of ectopic pregnancy
- hCG (serum)
- Transvaginal ultrasound
- Culdocentesis - nonclotted blood present (not done often)
- Laparoscopy
hCG trends
Should double q 24-48 hours
Absence of gestational sac with hCG levels > _________ strongly suggests ectopic or nonviable intrauterine pregnancy
> 2000
Management of unruptured/stable ectopic pregnancy
Methotrexate
Used if hCG < 5000, no fetal tones
Contraindications for methotrexate
Ruptured ectopic History of TB hCG > 5000 \+ fetal heart tones Noncompliant
Management of ruptured/unstable ectopic pregnancy
Laparoscopic salpingostomy
Laparotomy in severe cases
RhoGAM administration if mother Rh negative and unsensitized
Most common 2 causes of third trimester bleeding
Abruptio placentae
Placenta previa
Abruptio = \_\_\_\_\_\_\_\_\_\_\_\_ Previa = \_\_\_\_\_\_\_\_\_\_\_\_
Abdominal pain (usually severe) Painless
Abdominal placenta placement on or close to the cervical os
Placenta previa
Partial placenta previa
Covering of cervix ahead of fetal presenting part
Complete placenta previa
total coverage of cervical os
Sudden onset of painless bleeding (bright red) at 20-30 weeks. Resolves within 1-2 hours
Placenta previa
Fetal heart rate with placenta previa
Usually normal - no fetal distress
Diagnosis of placenta previa
Pelvic ultrasound to localize placenta - DO NOT perform pelvic exam
Management of placenta previa
Hospitalization - for stabilization
Stabilize fetus - magnesium sulfate - inhibits uterine contraction
Amniocentesis - to fetal lung maturity. Steroids given between 24-34 weeks
Delivery when stable
Risk factors for placenta previa
Multiparity
Increasing age
Smoking
Risk factors for premature rupture of membrarnes
STDs
Smoking
Prior preterm delivery
Multiple gestations
Diagnosis of premature rupture of membranes
- Sterile speculum exam: visual inspection, pooling of secretions
- Nitrazine paper test - if turns blue (pH > 6.5) - PROM likely
- Fern test - amniotic fluid - fern pattern - PROM
- Ultrasound - avoid digital exam
Management of premature rupture of membranes
Await spontaneous labor
Monitor for infection (chorioamnionitis or endometritis)
During pregnancy, hCG should _______ every __________ days and will plateau at __________ gestation
Double
2-3 days
10 week gestation
Intrauterine pregnancy is seen after hCG quantity reaches about ________ (or at about _______ weeks gestation)
2,000
5 weeks gestation
Gravida
Total number of pregnancies (including abortions)
Parity
Total number of births (over 20 weeks gestation)
Naegele Rule
First day of LMP - 3 months + days + 1 year = conception date
If pt has irregular menstrual periods, Naegele’s Rule should not be used, instead a __________ should be obtained for correct dating
US
Increase in plasma levels during pregnancy may lead to:
Hypotension Increased cardiac output Increased urinary frequency Anemia Increased GFR (decreased creatinine) Edema
Increased progesterone levels during pregnancy may lead to:
Relaxes smooth muscles
GERD
Constipation
Hyperventilation
Increased levels of estrogen, fibrinogen, and procoagulation factors during pregnancy lead to:
Hypercoagulable state
Increased blood flow to nasopharynx during pregnancy leads to
Rhinorrhea
Frequency of scheduled visits for pregnancy
Every 4 weeks until 30 weeks gestation
Every 2 weeks until 36 weeks gestation
Every week until delivery
Each pregnancy visit should include (4)
- BP check
- Urine dipstick
- Fundal height
- Fetal heart rate (110-160 bpm)
Pts who are AMA (> 35) and/or those with abnormal genetic screening are at increased risk for fetal aneuploidy
Testing can be done with (3):
- Chorionic villus sampling
(10-12 wks) - Amniocentesis (15-17)
- Cell-free fetal DNA (mother blood - done after 10 wks)
First trimester is defined as __________ wks gestation
1-12
If uterine size on physical exam does not correlate with last menstrual period
US should be obtained
The fundal height (cm) should correlate to the number of weeks between:
20-36 weeks gestation
Fetal heart rate may be heard at _________ with transvaginal ultrasound
6 weeks
Fetal heart rate can be heard with hand held doppler at ________ gestation
12 weeks
All first trimester pregnant patients need:
- Rhesus type and screen
- CBC
- Pap smear (only if due)
- Rubella titer
- Urinalysis
- Urine culture
- RPR
- Hepatitis B antigen
- Chlamydia screening
- Gonorrhea screening
- HIV
- HgA1c
- hCG quant
Pregnant pts with a HgA1c > ________ are diagnosed with DM
6.5%
Nuchal translucency ultrasound should be done from ________ wks gestation to r/o chromosomal abnormalities. This should be combined with first trimester serum testing (2)
11-13.6
PAPP-A (pregnancy associated plasma protein A)
hCG quant
Second trimester of pregnancy is defined as:
13-27 wks gestation
A quadruple screen should be done between 15-20 weeks gestation to screen for chromosomal abnormalities, including:
- AFP
- Unconjugated estriol
- hCG
- Inhibin A
Most common cause for an abnormal quad screen
Incorrect dating
Quickening (sensation of fetal movement) occurs between:
16-20 weeks gestation
Diabetes and anemia screening (CBC) should be done between __________ wks gestation. 2 DM screening options:
24-28 weeks
1. 75 g 2 hour (fasting) oral glucose tolerance test: only one abnormality is needed for diagnosis
2. 50 g 1 hour oral glucose tolerance test - not done fasting
If positive, over 140, pt should have 100 g 3 hour oral glucose tolerance test. Two abnormalities needed in 3 hour glucose challenge
Third trimester is defined as
28-40 wks gestation
If pt was found to be Rh negative, Rhogam prophylaxis should be administered at
28 weeks gestation (3rd trimester)
Vaccination that should be given to all pregnancies during third trimester
Tdap
If pt was found to have STD during initial screening, repeat testing is done during
Third trimester
GBS screening should be done at _________ wks gestation using a vaginal and rectal swab. If positive, prophylactic abx are given intrapartum
35-37 weeks gestation