Pulmonary hypertension

Question 1

Newer oral selective IP prostacyclin-receptor agonist for treatment of PAH

Answer 1

Selexipag. Most common SE -Headache

Question 2

Drug of choice in Pulm HTN secondary to CTEPH

Answer 2

Riociguat -soluble guanylate cyclase stimulator

Riociguat increases the level of cGMP->results in vasorelaxation ,antiproliferative and antifibrotic effects

Question 3

Right heart cath values indicating severity of Pulmonary HTN

Answer 3

Mild mPAP >20,Moderate mPAP >35, Severe mPAP>45

Question 4

Differentiating pre and post capillary cause of pulmonary HTN on cath

Answer 4

Post capillary -left heart related - high PCWP

Low PCWP - Pulmonary cause

Question 5

Calculation of pulmonary vascular resistance

Answer 5

PVR = PAP-PWCP/CO (Wood units)

If PVR is high - patient would need heart lung trnsplant

Question 6

MOA of selexipag

Answer 6

Selective oral IP prostacyclin receptor agonist