Pulmonary Hypertension Flashcards
1
Q
Define PHT?
A
A mean pulmonart arterial pressure > 25mmHg at rest
2
Q
What are the causes for PHT?
A
Idiopathic Left Heart Disease (e.g. Mitral Regurg) Chronic Pulmonary Disease Chronic Thromboembolic PH (CTEPH) HIV -- Congenital L-R Shunt -- Collagen Vascular Disease -- Portal Hypertension\
3
Q
What are the symptoms of PHT?
A
Exertional Dyspnoea and Syncope
Chest Tightness
4
Q
What aer the signs of PHT?
A
Raised JVP RV Heave Hepatomegaly Loud pulmonary heart sound Ankle Oedema
5
Q
What are the tests for PHT?
A
ECG CXR CT Pulmonary Angiogram Echocardiogram V/Q Scan Lung Function Tests Right Heart Catherterisation: - Pulmonary Arterial Pressure - Pulmonary Wedge Pressure - Cardiac Output
6
Q
How do we treat PHT?
A
Treat the underlyin cause
O2 - Anticoagulants - Diuretics - Vasodilating CCBs
Targeted vasodilators:
Phosphodiesterase Inhibitors e.g. sidenafil - Phosphodiesterase is a vasoconstricter
Prostacyclin - Vasodilator type of prostoglandin
Endothelin Receptor Antagonist e.g. Bosentan - Targets an excess endothelin (natural vasoconstrictor)
Lung/Heart Transplant
Thromboendarterectomy
7
Q
What does PHT lead to?
A
Right heart hypertrophy and Cor Pulmonale
