Pulmonary Hypertension Flashcards
What is pulmonary hypertension
Elevated pulmonary artery pressure due to an increase in resistance to blood flow through pulmonary circulation
Pulmonary hypertension is progressive, ____ , ______
chronic, incurable
Pulmonary Artery Mean (PAM) pressures
> 25 mmHg at rest
30 mmHg with exercise
Patho
Pulmonary arteries are blood vessels that carry blood from RIGHT side of heart to the LUNGS. So when arterial pressure rises blood backs up into the right side of the heart causing Greater resistance makes RIGHT SIDE of heart WORK HARDER to PUSH blood through the pulmonary arteries causing -> RIGHT VENTRICLE to thicken (vasoconstriction) and become enlarged and eventually fail causing RIGHT SIDED HEART FAILURE.
Types of PH
- Primary - Idiopathic
- Secondary - Chronic increase pulmonary artery pressure from another disease. Enlarged RV due to disorder of respiratory system, COPD or Interstitial lung disease; or clot.
Clinical Manifestation of Pulmonary Hypertension
Dyspnea
Fatigue
Lethargy
Weakness
Chest pain (exerctional)
Dizziness, Syncope
Diagnostic Studies
- Right sided heart catheterization* - measures pressures of blood vessels in lungs
- ECG
- Chest CT/Spiral CT
- Pulmonary function tests (PFTs) = not done in hospital, only done outpatient
- Vasoactivity Test
- Ventilation/perfusion scan
- Echocardiogram
- Pulmonary angiography= used dye, so watch for patients with kidney problems.
- 6-minute walk test = Outpatient
- Serology tests
- Sleep study= sometimes coexist with people with sleep apnea. Encourage people to use Cpap or Bipap because can lead to heart failure/issues.
Complications
- Cor-pulmonale (Right ventricular hypertrophy)
- Heart failure (right sided)
Right Sided Heart Failure Clinical Manifestations
Edema
Ascites
Liver Enlargement
JVD
Increased Right Arterial Pressure
Medications
a) Calcium Channel blockers (Lowers blood pressure) - diltiazem, nifedipine
b) Endothelin receptor antagonists (decrease pulmonary vascular pressure) - bosentan and ambrisentan
c) PDE-5 inhibitors (Phosphodiesterase inhibitors) (causes blood vessels to relax and widen, improving circulation and lower bp)–*sildenafil
and tadalafil– oral agents *Viagra (vasodilation)
d) Vasodilators (IV or inhaled) – iloprost, Treprostinil (monitor for hypotension because vasodilators can cause b/p to drop. Headaches are common. Also educate pt on orthostatic hypotension)
More Meds
e) Anticoagulants: give pt with a-fib heparin drip
f) Diuretics: give diuretics because pt might have heart failure
g) Oxygen: educate patient not to cook on gas stove or smoke if on oxygen, light candles, etc.
What medication for you avoid for pts with this
beta blockers and decongestants
*it can bronchoconstrict them
If a patient is on Sildenafil, no ____
nitrates
Surgical management
Atrial septostomy
remove part of atrium to get rid of some hyperany of muscle.
Surgical management
Pulmonary thromboendarterectomy
removes clotted blood from the pulmonary arteries. Cleans out arteries, may put stent