Pulmonary Flashcards
Primary function of the respiratory system
gas exchange
ventilation
movement of air between the atomosphere and the respiratory portion of the lungs.
Inspiration and expiration
perfusion
flow of blood through the lungs
diffusion
transfer of gases between the air filled spaces in the lungs and the blood
Muccociliary blanket
mucus produced by the epithelial cells in the conducting airways
conducting airways
through which air moves as it passes between the atmosphere and lungs
Respiratory tissues of the lungs
where gas exchange takes place
Inspiration
innnervated by the diaphragm. phrenic nerve roots from c4. people who lose function require mechanical ventilation
accessory muscles to inspiration
scalene and sternocleidomastoid muscles. scale -first two ribs. sternocleidomastoid: raise the sternum to increase the rise of the chest
Lobes of the lungs
3 in the right, 2 in the left.
Hyaline cartilage in the bronchi
surrounds the lumina of the bronchi, and replace the c shaped cartilage rings. two layers of smooth layers of muscles spiraling in opposite directions.
The cartilage gradually decreases as there is an increase in smooth muscle and elastic tissue. by the time the bronchioles are reahced, there is no cartilage present.
Bronchiospasms
narrowing of the bronchioles and impairs airflow
tidal volume
volume of air inspired of exhaled with each breath.
Inspiratory reserve volume
max amt of air that can be inspired
Expiratory reserve volume
max that can be exhaled
Residual volume
always remains in the lungs, approx 1200 ml
Forced vital capacity
full inspiration to total lung capacity followed by forceful maximal expiration
Maximum voluntary ventilation
volume of air a person can move in and out of the lungs during max effort lasting for 12-15 seconds
Forced expiratory vital capacity
full inspiration, forceful max expiration
forced expiratory volume
expiratory volume achieved in a given time period
forced inspiratory vital flow
resp response during rapid max inspiration
FEV1.0
FEV that can be exhaled in 1 second. used to diagnose obstructive lung disorders
Factors affecting alveolar capillary gas exchange
surface area available, thickness of the alveolar-capillary membrane, partial pressure of alveolar gases, solubility and molecular weight of the gas
Oxygen Dissociation curve
Right
rightward shift means that a higher PO2 is required to achieve similar level of hemoglobin saturation compared to the baseline. dec affinity, inc temp, inc 2,3 DPA, inc Pco2, dec pH
Oxygen Dissociation Curve LEft
less po2 can achieve a higher hemoglobin saturation compared to the baseline. a higher affinity for oxygen. dec temp, dec pco2, dec 2,3 DPA, inc pH.
Chemoreceptors: Central and Peripheral
Central: extremely sensitive to pco2, an increase in pco2 inc ventilation and peaks within a minute
Peripheral: carotid and aortic bodies. little control over ventilation until po2 drops below 60. hypoxia is main drive for ventilation
Pacemaker center
pneumotaxic center, apneustic center
CO2 Narcosis
people with chronically elevated levels of PCO2 no longer have a response to the stimulus for increased ventilation, but rely on stimuls of decrease in PO2 levels.
Dyspnea
subjective. shortness of breath.
observed in: primary lung diseases (pneumonia, asthma, emphysema), heart disease (pulmonary congestion), neuromuscular disorders (myasthenia gravis and muscular dystrophy)
Lower Respiratory infections mortality
most deadly communicable disease. tb is the most.
Viruses and respiratory infections
most frequent cause, range from self limited cold to life threatening pneumonia
Factors affecting signs and symptoms of respiratory tract
function of the structure involved, severity of the infectious process, persons age and general health status.
Transmission of the common cold
direct mucus membrane contact by fingers picking up the virus from contaminated surfaces and carrying it to the nasal membranes and the eyes
Acue bacterial rhinosinusitis
symptoms that worsen after 5-7 days or persist beyond 10 days, or symptoms that are out of proportion of those usually associated with a viral upper resp tract infection
Sinus films
do not differentiate between bacterial from viral
Rhinosinusitis: the need for medical attention
facial swelling over the involved sinus, abnormal extraocular movements, protrusion of the eyeball, periorbital edema, or changes int he mental status may indicate indtracranial complications
Influenza Viruses
type A: most common type. can infect multipe species. either Hemaglutanin and neuraminidase.
Antigenic Shift
major genetic rearrangement in either antigen, may lead to epidemic or pancdemic
antigenic drift
population mostly protected by cross reacting antibodies