Pulmonary Flashcards
Explain 2 stage testing.
If pt has never had PPD done before then the 2nd PPD is indicated w/in 1-2 weeks if the first test was negative to rule out falsely negative result. If second test negative then pt is truly negative. If second test is positive then pt is truly positive and the first test was falsely negative.
What is the alternative screening tool for pts who have the BCG vaccine?
Can do Inteferon Gmma Release assay which has no reactivity to BCG. However if pts have positive PPD due to BCG they must take isoniazid for 9 months No matter what!!!
What is the best initial test of Asthma? Most accurate test?
Best initial test depends on severity of asthma. If pt is having severe symptoms then ABG right away. If not then Peak Expiratory Flow. PFTs Most accuartate (Decrease in FEV1 more than FVC, Decrease FEV1/FVC ratio, Normal DLCO) If pt has no symptoms you can do Methacholine challenge test. Skin testing to identify specific allergens. IgE levels elevated.
State the for steps in treatment of Asthma 1-6.
- Short acting B 2. Lows dose ICS 3. Long acting B or increase ICS 4. High dose, leukotriene antagonist, long acting beta and short acting beta 5. Omalizumab 6. Oral Prednisone when all else fails.
Name the common oragnisms causing COPD exacerbation? Best initial test for COPD. Most accurate test?
S. pneumonia and H. influenza. CXR (increased AP diatmeter, flat diaphram) need to rule PNA to exclude diagnosis and as a cause of the exacerbation. Most accurate test is PFT (Decrease FEV1 more than FVC, Decrease in DLCO - emphysema, Normal in Bronchitis type.) EKG will show MAT(p waves of different sizes) or AFib due to R atrial dilation and RVH.
Name the different treatment steps for Chronic COPD.
Smoking cessation 02 therapy ( 2 things that decrease mortality) if p02 < 55 mmhg and sat < 88% or p02 < 60 mmg hg and sat <90% for R heart failure. 1. Beta 2 + anticholinergics (tiotropium or iotropium) Betas are not first line because pts usually have underlying heart disease 2. Theophylline (check abx.) Pulmonary rehab. When all else fails lung transplant.
Initial Management and treatment of Acute on Chronic Exacerbation of COPD.
CXR. Get ABG if severe. Always check levels of theophylline if pt is on that, CBC, ECG. Rx: 1. 02 2. beta 2/ipatropium (Combivent/Symbicort), 3. IV or PO steroids (Solumedrol) (determine if they can swallow Oral tabs) and 4. Azithromycin. Educate on smoking cessation if pt is still smoking.
Initial Management and treatment of Acute Exacerbation of asthma?
CXR and CBC to r/o infection causing the exacerbation. O2, Albuterol Neb, ICS.
Pt presents with reccurent pulmonary infections, sinsuitis, nasal polyps, meconium ileus, biliary cirrhosis, malabsorption, pancreatic insufficiency, steatorrhea, reccurent pancreatitis and gastro intestinal obstruction. Dx? Etiology? Most accurate test? Rx?
CF (AR CFTR gene mutations damage chloride and water transport across the apical surface of epithelial cells in exocrine glands. This leads to thick mucus. CXR. Sweat chloride test is most accurate. Rx: 1. Inhaled aminoglycosides and inhaled rH-deoxyribonuclease ( helps to break up the mucous) 3. Albuterol
- How do CF pts develop Diabetes? 2. Common complicaiton for boys with CF? 3. Common complication of boys and girls with CF?
- Do to recurrent pancreatitis leading to beta cell destruction. 2. Subinfertility (Azoserpmia, cant migrate to vas deferans due to thick secretions) 3. Chronic Rhinosinusitis.
Name the cause of PNA: 1. Recent viral syndrome 2. Alcoholics 3. GI symptoms+ confusion 4. Young, healthy pts 5. Person present at birth of an animal 6. Arizona Construction workers 7. HIV CD44 < 200
- S. Aureus 2. Klebsiella 3. Legionella 4. Mycoplasma 5. Coxiella burnetii 6. Coccidioiomycosis 7. PCP
Purpose of thoracentesis in pneumonia.
If pleural effusion is present we want to analyze the fluid for the presence of empyema which is infection pleural effusion. Effusions can be Exudative ( caused by infection or cancer: this meets lights criteria :increased vascular permeability) or transdutative( increased PCWP (left heart failure) or decrease oncontic pressure does not meet lights criteria). Lights criteria: 1. pleural protein/serum protein >0.5 ( pleural protein greater than 50% of serum 2. Pleural LDH/Serum LDH > 0.6 (pleural LDH is greater than 60% of the serum) 3. Pleural LDH fluid >2/3 the upper limit of the serum. Will show LDH 300s.
Name the specific diagnostic test for these organisms. Mycoplasma, Legionella, PCP (Pneumocystis)
- PCR and cold agglutins. 2. Urine antigen or Chorcal- yeast extract 3. BAL(Bronchoalveolar Lavage) For the other atypicals you can check serology (antibody titers)
Best initial test for PCP? Most accurate test? Rx? PCP prophylaxis?
Occurs in AIDS when CD4 count < 200. 1. CXR, ABG show hypoxia and increase A-a gradient 2. BAL most accurate. Sputum is quite specific. If sputum stain is negative then next is bronchoscopy . Rx: Bactrim. If toxicity to bactrim then Clindamycin and Primaquine (Contraindicated in G6PD) or Pentamidine. Prophylaxis: Bactrim if neutropenia or rash develop then Atovaquone or Dapsone (also contrainidcated in G6PD.)
Give 5 Classifications of Pulmonary HTN.
- Idiopathic Aterial pulmonary HTN 2. Increase venous black flow from left heart failure 3. Hypoxic vasocontriction 2/2 COPD 4. Chronic PE 5. Unclear etiology