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4 Pharma > PUD drugs > Flashcards

PUD drugs Flashcards

1
Q

PUD drugs that are lipophilic weak bases enabling diffusion across lipid membranes

A

PPI

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2
Q

Active form of PPIs

A

omeprazole sulfonamide

lansoprazole sulfone & hydroxylansoprazole

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3
Q

CYP450 member enzymes affecting PPI

A

CYP2C19

CYP3A4

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4
Q

Indications for PPIs

A 
GERD
PUD
non-ulcer dyspepsia
stress-related mucosal bleeding
gastrinoma (Zollinger-Ellison syndrome)
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5
Q

Common preparation of PPIs

A

enteric coated

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6
Q

Vitamin deficiency seen in chronic PPI use

A

vit b12

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7
Q

PPI that inhibits metabolism of warfarin, diazepam, and phenytoin

A

omeprazole

esomeprazole only decreases diazepam metab

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8
Q

Competitive inhibition of parietal cell H2 receptor

A

cimitidine
ranitidine
nizatidine
famotidine

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9
Q

H2 receptor blockers are particularly effective at

A

nocturnal acid secretion

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10
Q

Effect of food on PPI bioavailability

A

decreased by 50%

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11
Q

H2 blockers are rapidly absorbed where?

A

intestines

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12
Q

H2 blocker that does NOT inhibit first-pass metabolism of ethanol

A

famotidine

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13
Q

Creatinine and procainamide compete with H2 blockers for ____

A

renal tubular secretion

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14
Q

Contraindications for H2 blocker

A

pregnancy (crosses placenta)

lactating mothers (secreted in breastmilk)

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15
Q

Most potent H2 blocker

A

famotidine

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16
Q

H2 blocker that causes gynecomastia, male impotence and glactorrhea

A

cimetidine (prototype H2 blocker)

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17
Q

Systemic antacids

A

Na bicarbonate

Ca carbonate

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18
Q

1) Local antacid that causes diarrhea:

2) Local antacid that causes constipation:

A

1) Mg(OH)2

2) Al(OH)3

19
Q

Drugs that require acid for dissolution and absorption (should not be used with acid reducers)

A

digoxin, phenytoin, isoniazid, ketoconazole

20
Q

Drugs affected by gastric acidity

A

tetracycline
fluoroquinolone
itraconazole
iron

21
Q

When hypercalcemia and metabolic alkalosis caused by antacids

A

milk alkali syndrome

22
Q

Mucosal protective: binds to HCl and coats mucosal ulcer or erosions; absorbs bile salts

A

sucralfate

23
Q

Disadvantage of sucralfate

A

cannot be taken with acid reducers because it requires acid for activation

24
Q

Indication for sucralfate

A

duodenal ulcers

25
Q

Primary indication is NSAID-induced ulcer

A

prostaglandin analogs like misoprostol

Also used in PDA maintenance and induction of labor

26
Q

Misoprostol is rarely used as mucoprotective because:

A

1) ADR: induces abortion, causes diarrhea

2) 4x a day dosing

27
Q

Mucoprotective: stimulated PG, mucus, bicarb.

A

bismuth

28
Q

Mucoprotective with antimicrobial effects

A

bismuth

29
Q

Mucoprotective used for traveler’s diarrhea

A

bismuth

sucralfate possibly

30
Q

H. pylori antimicrobial duration

A

10-14 days

31
Q

Combination therapy for H. pylori

A

acid reducer + 2 antibiotic (usually metro + another)

PPI + metro + clarithro

32
Q

Most common site of NSAID-induced ulcers

A

antrum

33
Q

PPI vs misoprostol: rate of healing

A

PPI > misoprostol

34
Q

PPI vs misoprostol: erosion healing

A

PPI < misoprostol

35
Q

Vomiting, retching or coughing preceding/causing HEMATEMESIS (seen in alcoholics especially).

A

Mallory-Weiss tear

36
Q

Drug used in Mallory-Weiss tears

A

vasopressin

37
Q

Drug indicated in acute esophageal variceal bleeds

A

octreotide

somatostatin

38
Q

Primary indications include: carcinoid tumor

A

octreotide

39
Q

Primary indications include: VIPoma

A

octreotide

40
Q

V1 receptors mediate

A

vasoconstriction (vasculature smooth muscles)

41
Q

V2 receptors mediate

A

antidiuresis (renal tubule)

42
Q

Indicated for diabetes insipidus an nocturnal enuresis

A

vaspressin/desmopressin

43
Q

Reduces incidence and severity of post-op complications in PANCREATIC SURGERY

A

octreotide

44
Q

Acromegaly

A

octreotide (somatostatin)

4 Pharma (7 decks)

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