Antiviral and Antifungal Flashcards
HIV receptor?
CD4+
HIV co-receptor?
CCR5
CXCR4
What part of HIV binds to CD4+ receptor?
Env gp 120
What part of HIV fuses with host membrane?
gp 41
This anti-HIV drug TARGET that splices polyproteins
protease
This anti-HIV drug TARGET which acts on host DNA to form proviral DNA
reverse transcriptase
RNA-dependent DNA polymerase
This entry/fusion inhibitor (anti-HIV) binds to CCR5
maraviroc
gp120 cannot bind to CCR5 –> blocks entry
This entry/fusion inhibitor (anti-HIV) binds to gp41
enfuviritide
blocks fusion of membranes. uses gp41 not gp120 because of gp120’s mutation frequency
This entry/fusion inhibitor requires tropism test (HIV tropism = what cell the HIV infects) and Tx-experienced adults.
(Not for CXCR4 tropic or dual/mixed R5X4)
maraviroc
Binds to CCR5 not CXCR4
This entry/fusion inhibitor acts on T-cell
Maraviroc (CCR5)
This entry/fusion inhibitor acts on HIV
enfuviritide (gp41)
Anti-HIV drug TARGET that inserts viral cDNA into host genome.
integrase
RTI subgroup that:
1) are prodrugs: chain terminators
2) are myelosuppressive
NRTIs
RTI subgroup that are NOT prodrugs and do not cause myelosuppression
NNRTIs
Which nucleoside reverse transcriptase inhibitor acts on nucleoTide not nucleoSide
tenofovir
Non-competitive inhibition of RT by NNRTI is achieved by:
binding to HIV-1 RT away from catalytic site
These anti-HIV drugs cause lactic acidosis and hepatic steatosis
NRTIs
NRTI that causes most BM depression
zidovudine, ZDV
aka azidothymidine or AZT
NRTI that causes peripheral neuropathy and pacreatitis
stavudine
didanosine
zalcitabine
NRTI that causes headache/nausea/fatigue
lamivudine
LEAST TOXIC NRTI
NRTI that causes hyperpigmentation
emtricitabine
Newer, more active form of lamivudine
NRTI that causes rash/HSR (5% patients develop allergy)
abacavir
NRTI that causes nephropathy
tenofovir
Which group of anti-HIV drugs require phosphorylation? (thymidine kinsase)
NRTIs
NNRTIs are metabolized by
CYP450 (CYP3A4 inducer)
HIV drug that causes insomnia and nightmares:
efavirenz
HIV drug that causes insomnia and depression
rilpivirine
NNRTI’s that causes rash
nevirapine
delavirine
etravirine
Integrase inhibitor:
raltegravir
inhibiting HIV integrase prevents the insertion of HIV DNA into human genome
HIV drug that causes toxic epidermal necrolysis
raltegravir
-navir drugs =
protease inhibitors
think NAVIR/never TEASE
These HIV drugs block cleavage of polyproteins
protease inhibitors
Inhibition of HIV-1 protease results in the production of these particles:
non-infectious virions
Least potent protease inhibitor, also least toxic and lowest bioavail
saquinavir
Most potent protease inhibitor.
ritonavir
Protease inhibitor always formulated in combination with ritonavir
lopinavir
Ritonavir inhibits CYP34A metabolism of this protease inhibitor
lopinavir
Protease inhibitors that cause sulfa allergy
darunavir
tipranavir
fosamprenavir
DTF
Protease inhibitor that has replaced amprenavir
fosamprenavir
Protease that causes most drug interactions by acting on CYP450 groups
ritonavir
induce 1A2
inhibit 2D6, 3A4
Fixed combo of elvitegravir, cobicistat, tenofovir, emtricitabine:
Stribild
Elvitegravir is ONLY used in this combination.
Fixed combination of tenofovir + emtricabone
Truvada
Drug group that causes DM Type 2 like syndrome: hyperglycemia, lipodystrophy
Protease inhibitors
Fusion inhibitor for HSV-1?
docosanol