Drugs for Jaundice

Question 1

Yellowing of skin differential:

Answer 1

jaundice
carotenoderma
quinacrine use
excessive phenol exposure (such as wintergreen oil)

Question 2

Anticonvulsant used to reduce serum bilirubin levels

Answer 2

phenobarbital

increases conjugation and excretion

Question 3

Phenobarbital used with ____ may produce additive CNS effects, death

Answer 3

ethanol

Question 4

Phenobarbital is an enzyme ____

Answer 4

inducer (thus decreases effects)

Question 5

Dyslipidemia drug used to reduce serum bilirubin

Answer 5

clofibrate

used in prolonged jaundice in young age groups

Question 6

Drugs indirectly causing hyperbilirubinemia

Answer 6

rifampicin
probenecid
ribavirain

Question 7

Dugs that may cause hemolysis due to G6PD def.

Answer 7

Dapsone

Cotrimoxazole

Sulfonamides

Aspirin

Anti-malarials eg: primaquine

Nitrofurantoin

phenacetin

probenecid

chloramphenicol

Question 8

Industrial chemical causing hepatotoxicity

Answer 8

vinyl chloride

Question 9

Herbal preparations causing hepatotoxicity

Answer 9

mushrooms: amanita phalloides or verna

Question 10

Races more susceptible to isoniazid tox

Answer 10

blacks and hispanics

also women, elderly

Question 11

Drug-induced liver injury can occur in DM patients with these drugs

Answer 11

methotrexate

niacin

Question 12

Drug-induced liver injury can occur in renal failure patients with these drugs

Answer 12

tetracycline, allopurinol

Question 13

Drug-induced liver injury can occur in AIDS patients with these drugs

Answer 13

dapsone, cotrimoxazole

Question 14

Drug-induced liver injury can occur in females or obese with this drug

Answer 14

halothane

Question 15

Antibiotics used in acute cholecystitis

Answer 15

ampicillin

ampicillin/sulbactam

piperacillin/tazobactam

Question 16

Indication: pseudomonal acute cholecystitis

Answer 16

piperacillin and tazobactam

Question 17

Indication: covers epidermal flora, enteric flora, anaerobes. NOT for nosocomial infections

Answer 17

ampicillin and sulbactam

Question 18

Synergistic effect with piperacillin/tazobactam

Answer 18

aminoglycosides

Question 19

Used in pain caused by cholecystitis

Answer 19

meperidine (demerol)

DOC

Question 20

Most widely used oral bile salt compound

Answer 20

ursodeoxycholate

Question 21

Used to dissolve galltones,in microlithiasis and primary biliary cirrhosis in people who are poor surgical candidates

Answer 21

ursodeoxycholate

Question 22

Decreases cholesterol content of bile and bile stones

Answer 22

ursodeoxycholate

Question 23

Drugs associated with intrahepatic cholestasis

Answer 23

steroids (anabolic and contraceptive)
cimetidine
sulindac (NSAID)
antibiotics such as eryhto, cotrimox, penicillines

Question 24

Chronic cholestasis is associated with what drugs?

Answer 24

chlorpromazine

prochlorperazine