PUD Flashcards
There is a 4x greater incidence of ___ ulcers than ___ ulcers.
duodenal, gastric
___ ulcers tend to peak in older pts.
gastric
___ ulcers take about 2 wks longer to heal.
gastric
Goal w/PUD is to eradicate ___.
H. Pylori
___ is the predominant factor for recurrent ulcers, but others include:
H. Pylori, smoking, NSAIDS, hypersecretion, noncompliance
Tx for H. Pylori is ___ antibx + a ___ or ___ antagonist.
2, PPI, H2
First-line tx for H. Pylori is: ___. Total of ___ pills per day. Take for ___ wks.
Amoxicillin OR Tetracycline + Flagyl + PPI (or H2), 15, 2
Examples of H2 antagonists:
ranitidine (zantac), cimetidine (tagamet), nizatadine (Axid), famotidine (pepcid)
Ideal duration of tx for duodenal ulcers is ___-___wks, ___-___ wks for gastric, and ___-___ wks for older pt or smoker.
4-6, 8-12, 6-8
DOC for H2 antagonists is ___.
famotidine (pepcid)
Purpose of H2’s is to ___ histamine receptors and block ___.
block, acid
Purpose of antacids is not to block acid, but to ___ it. Used for ___ symptom relief.
neutralize, PRN
Examples of antacids include:
Calcium carbonate (TUMS), Mylanta, Maalox
Limit use of ___ ___ d/t rebound acid effect.
calcium carbonate
The medication ___ binds to and protects ulcers from acid and allows for healing of the ulcer.
sucralfate (carafate)
DOC for pregnancy is ___ d/t its nonsystemic effects.
sucralfate
Cytoprotective agents include:
sucralfate (Carafate), misoprostil (Cytotec), bismuth salts (Pepto-Bismol)
___ has antibx effects against H. Pylori and is therefore used in the combination of tx.
bismuth
Proton Pump Inhibitors (PPI’s) include:
omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), Nexium
PPI’s have a dramatic ___ in gastric acid by interfering w/the ___/proton pump.
reduction, ATP-ase
PPI’s should be used for ___-___ wks and heal ulcers ___ than H2’s.
4-8, faster
Avoid use of ___ while on PPI’s d/t drug interaction.
ketoconazole
___ are the DOC for tx AND prophylaxis of PUD. They heal ___ than H2’s.
PPI’s, faster
___ are DOC for NSAID-induced ulcers.
PPI’s
Monitor ___ effects and ___ effects w/H2’s.
renal, CNS
___ is the only way to conclusively select between GU and DU.
Endoscopy
General tx includes: stop ___, minimize ___ use, and avoid ___ foods.
smoking, alcohol, exacerbating
Dx H. Pylori w/___.
biopsy
H. Pylori needs an ___ environment to live and thrive.
acidic
Low pH indicates an ___ environment. High pH indicates an ___ environment.
acidic, alkaline
MOC stands for:
MOA stand for:
metronidazole, omeprazole, clarithromycin
metronidazole, omeprazole, amoxicillin
It is equipotent whether you give your entire dosing once dly or if you split it up for ___. Whereas, it might be more effective split up for ___.
PUD, GERD
Misoprostil (Cytotec) is used for ___-induced gastric ulcers.
NSAID
PPI’s block ___ acid pathways of acid, gastrin, and pepsin. H2’s do not.
ALL
___ pump is also known as the proton pump.
ATP-ase
Don’t combine ___ w/H2’s.
PPI’s
