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Reproductive System > Puberty Disorders > Flashcards

Puberty Disorders Flashcards

1
Q

What is precocious puberty?

A

Puberty that occurs at an age before the normal population
<8 years in girls
<9 years in males

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2
Q

What age is precocious puberty in girls?

A

< 8 years old

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3
Q

What age is precocious puberty in boys?

A

< 9 years old

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4
Q

What are the two types of precocious puberty?

A
  • Central: follows normal pattern of puberty | GnRH dependent
  • Peripheral: doesn’t follow normal pattern of puberty | GnRH independent
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5
Q

What is central precocious puberty?

A

Precocious puberty with elevated GnRH levels
(Premature activation of the HPA axis)

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6
Q

Causes of central precocious puberty

A
  • idiopathic (most common)
  • CNS lesions
  • systemic conditions: tuberous sclerosis, neurofibromatos
  • obesity
  • pituitary gonadotropin secreting tumours (rare)
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7
Q

How do you diagnose central precocious puberty?-

A
  • high levels of LH + FSH
  • high levels of testosterone in boys
  • high levels of oestrogen in girls
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8
Q

What is peripheral precocious puberty?

A

Precocious puberty without elevated GnRH levels

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9
Q

Causes of peripheral precocious puberty

A

-increased androgen production: e.g. ovarian cyst (most common) + congenital adrenal hyperplasia
- increased oestrogen production: e.g. HCG-secreting germ cell tumours
- increased B-HCG production: e.g. hepatoblastoma, primary hypothyroidism, obesity related

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10
Q

Diagnosis of peripheral precocious puberty

A
  • decreased LH + FSH
  • increases testosterone or oestrogen
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11
Q

Why do lab tests show decreased LH + FSH in peripheral precocious puberty?

A

GnRH is suppressed by elevated gonadal hormones

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12
Q

What occurs first in peripheral precocious puberty?

A

Adrenarche (pubic/axillary hair growth)

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13
Q

What is delayed puberty?

A
  • Late start of puberty
  • > 13 years in girls
  • > 14 years in boys
  • Or failure of developmental progression over a 2 year period
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14
Q

Causes of delayed puberty

A
  • constitutional delay
  • hypothalamic suppression
  • chromosomal abnormalities
  • hypogonaotrophic hypogonadism
  • low body weight
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15
Q

What is the difference in lab tests between central and peripheral precocious puberty?

A
  • Central: high LSH + FH
  • Peripheral: low LSH + FH
  • Both high testosterone or oestrogen
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Reproductive System (20 decks)

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