Pubertal Development Flashcards
What is the normal sequence of pubertal development?
Thelarche (Breast Development) - 8-9 yr.
Axillary and Pubic Hair (Adrenarche/Pubarche) - 9-10 yr.
Growth Spurt (Near maximum height)
Menarche - 12-13 yr.
Factors that determine the onset of menses
biological age body weight percent composition of body fat family history maturation of CNS (development of positive feedback response to estradiol)
Regulation of menstration
Hypothalmus: Releases GnRH
Pituitary Gland: secret LH and FSH to the ovary
Ovary:
Theca cells - LH - Secrete androgens (precursors for estrogens)
Granulosa Cells- FSH - Secrete androgen precursors, estradiol
When does ovulation occur?
14 days prior to the next cycle
Average interval from one cycle to the next? Range?
28 days is average with the range being 21-35 days
Whats is the dominant ovarian steroid in the early part of cycle?
estradiol
What makes the lining of the uterus hospitable to recieve a fertilized egg?
after ovulation, corpus luteum secretes progesterone
How long does bleeding usually last?
3-5 days
The endometrium goes from the _________ stage to the ___________ stage as estradiols prevalence diminishes and progesterones increases.
proliferative; secretory
What causes ovulation?
rising estradiol creates mid-cycle LH surge, thus ovulation
What cells are involved in the two cell hypothesis?
theca cells and granulosa cells
What does the hypothalamus release for menstruation?
GnRH in a pulsatile manner, important for normal development
What does the GnRH act upon?
The pituitary gland, causing the release of FSH and LH
What cells do LH and FSH act upon respectively? Where are these cells located?
LH- Theca cells
FSH- Granulosa cells
They are int he ovaries
What do Theca cells secrete?
androgens, precursors for estrogens
