PT1 - Transaminases and creatine kinase

Question 1

Features of group transfer reactions

Answer 1

1. Endergonic+exergonicreactions=netΔGnegative
2. reversible reactions
3. catalysed by an enzyme
4. Transfer molecule (coenzyme or prosthetic group; often a vitamin or a vitamin derivative)

Question 2

Some examples of of group transfer reactions

Answer 2

Question 3

What is Transamination?

Answer 3

The transfer of an amino group

Question 4

What type of metabolism that involve transamination?

Answer 4

Amino acid metabolism (e.g, breakdown)

Question 5

What is the possible way to eliminate an amino group?

Answer 5

Transamination

Question 6

What is the aim of transamination during breakdown?

Answer 6

carbon chain utilization: breakdown or synthesis

Question 7

Identify these substances

Answer 7

Question 8

What is Transdesamination?

Answer 8

= transamination + desamination

Question 9

What will alpha-keto acid be used?

Answer 9

Make glucose or energy

Question 10

What will H4N+ do afterwards?

Answer 10

secretion

Question 11

Name of this process

Answer 11

Malate shuttle

Question 12

Where can you find Aspartate amino transferase?

Answer 12

Heart muscle, liver and in all other organs

Question 13

The reaction that Aspartate aminotransferase catalyze?

Answer 13

ASAT, (s)GOT

Question 14

Diseases of Aspartate aminotransferase deficiency

Answer 14

• MIOCARDIAL INFARCTION,
  rheumatic heart disease, heart
  surgery
• To a lesser extent in liver damage

Question 15

Reaction that Alanine aminotransferase catalyze?

Answer 15

ALAT, (s)GPT

Question 16

Where can you find Alanine aminotransferase?

Answer 16

LIVER>kidneys>heart>sceletal muscle>other organs

Question 17

Diseases of Alanine aminotransferase deficiency

Answer 17

• Liver damage (cirrhosis, hepatitis, mononucleosis)
• To a lesser extent: miocardial infarction

Question 18

Diagnostic significance of transaminases
-> What is appropriate ASAT/ALAT ration?
-> Lesser or greater can cause which diseases?

Answer 18

Liver damage < 1.3 < miocardial infarction

Question 19

The role of Creatine kinase

Answer 19

Question 20

Where can you find Creatine kinase

Answer 20

Heart-, and skeletal muscle, brain