PT1 - Transaminases and creatine kinase Flashcards
Features of group transfer reactions
- Endergonic+exergonicreactions=netΔGnegative
- reversible reactions
- catalysed by an enzyme
- Transfer molecule (coenzyme or prosthetic group; often a vitamin or a vitamin derivative)
Some examples of of group transfer reactions
What is Transamination?
The transfer of an amino group
What type of metabolism that involve transamination?
Amino acid metabolism (e.g, breakdown)
What is the possible way to eliminate an amino group?
Transamination
What is the aim of transamination during breakdown?
carbon chain utilization: breakdown or synthesis
Identify these substances
What is Transdesamination?
= transamination + desamination
What will alpha-keto acid be used?
Make glucose or energy
What will H4N+ do afterwards?
secretion
Name of this process
Malate shuttle
Where can you find Aspartate amino transferase?
Heart muscle, liver and in all other organs
The reaction that Aspartate aminotransferase catalyze?
ASAT, (s)GOT
Diseases of Aspartate aminotransferase deficiency
- MIOCARDIAL INFARCTION,
rheumatic heart disease, heart
surgery - To a lesser extent in liver damage
Reaction that Alanine aminotransferase catalyze?
ALAT, (s)GPT
Where can you find Alanine aminotransferase?
LIVER>kidneys>heart>sceletal muscle>other organs
Diseases of Alanine aminotransferase deficiency
- Liver damage (cirrhosis, hepatitis, mononucleosis)
- To a lesser extent: miocardial infarction
Diagnostic significance of transaminases
-> What is appropriate ASAT/ALAT ration?
-> Lesser or greater can cause which diseases?
Liver damage < 1.3 < miocardial infarction
The role of Creatine kinase
Where can you find Creatine kinase
Heart-, and skeletal muscle, brain
