4. Metabolism of nucleotides Flashcards by Aurora H

Q

Biological roles of nucleotides

A

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Q

The fate of nucleotides in the intestine

A

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Q

Degradation of nucleosides

A

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Q

Degradation of nucleosides

A

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Q

Degradation of purine bases

A

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Q

Antioxidant effects of uric acid (UA)

A

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Q

Balanced pro‐ and anti‐oxidant effects of uric acid (UA)

A

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Q

Excretion and reabsorption of uric acid in the kidney
-> The role of Thiazide diuretics

A

‐direct effect: MRP4 inhibition, OAT4 substrate
‐indirect effect: Na+ loss => NPT1 ↓,

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Q

What is the Treatment of gout

A

uricolytic, uricosuric, uricostatic

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Q

Salvage of purine bases
-> describe Synthesis of phosphoribosyl‐pyrophosphate?

A

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Q

Salvage reactions of purine bases

A

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Q

Regulation of the purine salvage

A

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Q

De novo synthesis of purine nucleotides

A

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Q

The role of PRPP amidotransferase in the de novo synthesis of purine nucleotides

A

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Q

Regulation of the de novo synthesis of purine nucleotides

A

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Q

Degradation of uracil

A

End products:
‐ acetyl‐CoA
‐ propionyl‐CoA

Q

Degradation of thymine (pyrimidine bases)

A

End products:
‐ acetyl‐CoA
‐ propionyl‐CoA

Q

Degradation of beta‐alanine

A

Q

Degradation of beta‐aminoisobutyrate

A

Q

Salvage reactions of pyrimidine bases

A

Q

Salvage reactions of pyrimidine nucleosides

A

Q

De novo synthesis of pyrimidine nucleotides

A

Q

CTP synthesis

A

Q

Regulation of the de novo synthesis of pyrimidine nucleotides

A

Synthesis of deoxyribonucleotides

Structure of ribonucleotide reductase

Regulation of ribonucleotide reductase

dTMP synthesis

What are Cytostatic drugs?

antifolates

Examples of Chemotherapeutic drugs in the treatment of tumours

antimetabolites

How do Antimetabolites as anti‐viral drugs work?