4. Metabolism of nucleotides Flashcards by Aurora H | Brainscape

Q

Biological roles of nucleotides

A

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Q

The fate of nucleotides in the intestine

A

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Q

Degradation of nucleosides

A

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Q

Degradation of nucleosides

A

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Q

Degradation of purine bases

A

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Q

Antioxidant effects of uric acid (UA)

A

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Q

Balanced pro‐ and anti‐oxidant effects of uric acid (UA)

A

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Q

Excretion and reabsorption of uric acid in the kidney
-> The role of Thiazide diuretics

A

‐direct effect: MRP4 inhibition, OAT4 substrate
‐indirect effect: Na+ loss => NPT1 ↓,

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Q

What is the Treatment of gout

A

uricolytic, uricosuric, uricostatic

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Q

Salvage of purine bases
-> describe Synthesis of phosphoribosyl‐pyrophosphate?

A

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Q

Salvage reactions of purine bases

A

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Q

Regulation of the purine salvage

A

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Q

De novo synthesis of purine nucleotides

A

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Q

The role of PRPP amidotransferase in the de novo synthesis of purine nucleotides

A

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Q

Regulation of the de novo synthesis of purine nucleotides

A

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Q

Degradation of uracil

A

End products:
‐ acetyl‐CoA
‐ propionyl‐CoA

Q

Degradation of thymine (pyrimidine bases)

A

End products:
‐ acetyl‐CoA
‐ propionyl‐CoA

Q

Degradation of beta‐alanine

A

Q

Degradation of beta‐aminoisobutyrate

A

Q

Salvage reactions of pyrimidine bases

A

Q

Salvage reactions of pyrimidine nucleosides

A

Q

De novo synthesis of pyrimidine nucleotides

A

Q

CTP synthesis

A

Q

Regulation of the de novo synthesis of pyrimidine nucleotides

A

Q

Synthesis of deoxyribonucleotides

A

Q

Structure of ribonucleotide reductase

A

Q

Regulation of ribonucleotide reductase

A

Q

dTMP synthesis

A

Q

What are Cytostatic drugs?

A

antifolates

Q

Examples of Chemotherapeutic drugs in the treatment of tumours

A

antimetabolites

Q

How do Antimetabolites as anti‐viral drugs work?

A