psychosis

Question 1

define withdrawal vs stupor in context of catatonia

Answer 1

WD: refusal to eat, drink, make eye contact
stupor: extreme hypoactivity, immobility, min response to stim

Question 2

gender w later age onset in SCZ

Answer 2

F 25-35, M 18-25

…but also have longer time to dx, better social functioning & long term prognosis!

Question 3

brain activity during AH

Answer 3

activation of primary auditory cortex, Heschl’s gyrus, overactivation of temporal-parietal cortex

Question 4

first-line class of meds for co-occurring SCZ + SUD

Answer 4

antipsychotics

Question 5

suicide risk factors SPECIFIC to SCZ

Answer 5

high SES, greater illness insight, high IQ w high prior edu, high expectations, young age/early onset and 1st hosp, chronic course w deterioration & freq relapse

Question 6

another name for DiGeorge, incidence of SCZ

Answer 6

VCFS (VeloCardioFacial synd), 22q11.2 deletion, 25% develop SCZ

CATCH-22:
Cardiac abn (tetralogy of Fallot)
Abn facies (microceph/gnath)
Thymic aplasia
Cleft palate
HypoCa/PTH

Question 7

duration of SCZ, brief psychotic, & schizophreniform

Answer 7

brief: <1m
schizophreniform: 1-6m
SCZ: >6m

Question 8

provisional & good prognosis specifiers

Answer 8

provisional = dx before recovery

good prognosis = full range affect, confusion/perplexity

Question 9

% pts with untreated endo do w psychosis

Answer 9

20!

Question 10

incidence of catatonia in hospitalized psychosis vs mood

Answer 10

7-17%, 13-31%

Question 11

who coined terms dem praecox, SCZ, SAD, schizophreniform

Answer 11

SCZ: bleuler
DP: kraepelin (vs manic depr psychosis = bipolar)
SAD: kasanin
SP: langfeldt

Question 12

x inc risk SCZ w 1st degree relative

Answer 12

10x

Question 13

good prognosis for schizophreniform

Answer 13

2+: psychotic sxs w/in 4w of first change, confusion, previously good fxn, no flat affect

Question 14

tx for anticholinergic OD

Answer 14

physostigmine

Question 15

D1 vs D2

Answer 15

hyperDA @striatal D2 > + sxs

hypoDA @prefrontal D1&raquo_space; neg sxs

Question 16

% D2 block for EPS

Answer 16

> =80%

Question 17

1G or 2G for neg sxs?

Answer 17

2G

Question 18

antipsychotics treat + or - sxs best

Answer 18

+

Question 19

NMS tx

Answer 19

bromocriptine, dantrolene, amantadine, benzos

Question 20

hypnogogic vs pompic

Answer 20

GOgic = when GOing to sleep

pompic = when waking up