mood (depression, mania) Flashcards

1
Q

cyclothymic criteria

A

multiple periods of hypomanic & depressive sxs that do NOT meet criteria for full episodes for over 2y (w/o euthymic for more than consecutive 2m)

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2
Q

bipolar depression FDA approved meds

A

symbyax, seroquel, latuda

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3
Q

remission from MDE per APA guidelines

A

at least 3w absence of dysphoria + anhedonia AND <=3 remaining sxs

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4
Q

risk of bipolar with dx in 1st degree relative

A

10%

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5
Q

minimum duration for hypomanic v manic episode

A
hypomanic = 4d
manic = 1w or ANY if hospitalized
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6
Q

basic manic/hypomanic criteria

A

elevated/irritable mood + 3 of dec need for sleep, inc activity/agitation, out of character risky activities, grandiosity, talkativeness, FoI, distractability

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7
Q

neuro finding in late onset mania

A

R hemispheric & subcortical lesions…. higher relative mortality than pts w mania throughout adulthood

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8
Q

suicide rate in bipolar

A

10-15%

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9
Q

bipolar first episode is most often which type

A

depression

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10
Q

are depressive/manic episodes more common in each gender

gender ratios in bipolar 1 vs 2

A

M: manic >= depression
F: depression > manic

1: F = M
2: F > M

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11
Q

when in gestation is VPA teratogenic

A

3-6 weeks (before aware of pregn)

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12
Q

define rapid cycling specifier

more common in M or F?

A

> =4 major depressive, manic, or hypomanic episodes in past year

F > M

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13
Q

effect of Li in PD

A

may be neuroprotective long term?!

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14
Q

% of ppl w CV dz who develop depression?

A

25+

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15
Q

lamictal FDA indication?

A

bipolar 1 maintenance

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16
Q

adjustment prognosis for adults v teens

A

teens more guarded bc more likely to develop major mental illness

adults prognosis good once stressor terminated

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17
Q

kava kava & st johns wort showed benefit for what conditions in RCTs, respectively?

A
KK = anxiety
SJW = somatoform
18
Q

MC comorbid mental illness in epilepsy?

A

depression (7.5% prevalence, up to 50% in intractable)

19
Q

incidence of depression on isotretinoin

A

4-11% although studies are poor… also must be addressed beyond DC med

*ALL prescribers must participate in iPLEDGE (ie even male pts). many risks including dec night vision, corneal opacities,

20
Q

% of suicides that are gero

A

20% (only make up 13% of whole pop)

21
Q

top 2 causes of death in adolescents

A

accidental injuries 40%, suicide 19.2%

22
Q

mean age of onset for bipolar disorder (any episode) & % who have recurrent episodes

A

18yo, >90%

23
Q

features of atypical depression

A
  • inc appetite/wt gain, mood reactivity, interpersonal rejection sensitivity, leaden paralysis
  • F>M, more in bipolar 1/2, earlier age, more chronic
  • MAOIs best
24
Q

Li effect on birthweight

A

increase

25
Q

when is Li safe during pregnancy

A

2nd/3rd T, but stop before birth bc possible fluid shifts from change in glom filtration

26
Q

how to address Li side effects: nausea, diarrhea, hypothyroid, tremor, edema, polydipsia/polyuria

A
  • nausea: w food, SR (to dec peak conc)
  • diarrhea: IR (to dec distal absorp/serum conc)
  • hypothyroid: T3
  • tremor: propranolol or primidone
  • edema: spironolactone
  • polydipsia/polyuria: amiloride or HCTZ (halve Li dose an follow levels)
27
Q

M:F prevalence of MDD, bipolar 1, SCZ, ADHD, tic

A
MDD: 1:1.5-3
BPD: 1.1:1
SCZ: 1.4:1
ADHD: 1.6-2:1
tic: 2-4:1
28
Q

sleep changes in MDD

A

inc latency, dec slow wave (phase 3) bc dec blood flow in orbitofrontal & ant cingulate, dec REM latency, inc REM eye movements, & dec total sleep

29
Q

med for HepC and risk of mental illness

A

IFNa, up to 40% risk depression in 2-4 months, use ppx antidepr

30
Q

bupropion + TCA interaction?

A

WB inhib 2D6 > INC TCA lvl&raquo_space; antichol side effects ie blurred vision, urinary ret, constip, dry mouth, etc

31
Q

antidepressants w highest v lowest risk of switch to mania

A

highest: effexor
lowest: WB

32
Q

% bipolar who attempt suicide at least once, risk of death by suicide compared to gen pop, % of suicides due to bipolar

A

25-50%, 10-25x gen pop, 25%

33
Q

antidepressant w/o indication for anxiety

A

WB

34
Q

how many non overlapping sxs for mixed features specifier

A

3

35
Q

VPA MoA, OD

A

blocks volt gated Na channels > inc GABA lvls

OD: CNS depr but rarely fatal, can remove w HD

36
Q

days to reach Li steady state, timing to obtain trough

A

5 days, 12h after dose

37
Q

paxil % protein bound & % excreted in urine

A

95% protein bound, 66% excr in urine

38
Q

NT w most evidence in OCD

A

serotonin, low @BG

DA, high @PFC (mesocortical)

39
Q

premenstrual dysphoric do DSM5 criteria ABC categories

A

A timing
B mood
C associated sxs

40
Q

% of suicide completions with psych disorder

A

95%

41
Q

risk of suicide anx vs depr

A

anx more than double depr