Psychosis

Question 1

typical neuroleptics

Answer 1

chlorpromazine
flupenthixole
haloperidol

Question 2

moa of typical neuroleptics

Answer 2

D2 antagonists

Question 3

useful effects of typical neuroleptics

Answer 3

1. good for positive symptoms

2. sedative

Question 4

SE of typical neuroleptics

Answer 4

1) extrapyramidal symptoms (EPS)
2) no effect on negative symptoms
3) hyperprolactinaemia
4) aplastic anaemia

Question 5

what other receptors do chlorpromazine effect?

Answer 5

1. anti-H1 (sedative)
2. anti-mAch (can slightly improve the parkinsons)
3. anti-alpha1 (hypotension)

Question 6

atypical neuroleptics

Answer 6

clozapine
Risperidone
olanzapine

Question 7

moa of atypical neuroleptics

Answer 7

1. weak antagonist of D2,
2. antagonist of 5-HT2A/2C (excitatory)
3. partial agonist of 5-HT1A, 4. antagonist mAChR and alpha-2 adrenoceptor

Question 8

useful effects of atypical neuroleptics/3rd gen

Answer 8

1. effects on positive and negative symptoms
2. good for drug resistance
3. less EPS

Question 9

what is a main SE of clozapine?

Answer 9

agranulocytosis

Question 10

SEs of atypical neuroleptics

Answer 10

1) Long QT interval
2) Weight Gain/Type 2 DM
3) Agranulocytosis

Question 11

3rd gen neuroleptic

Answer 11

aripiprazole

Question 12

MOA of aripiprazole

Answer 12

1. D2 partial agonist,
2. 5-HT2A antagonism
3. partial agonist of 5-HT1A

Question 13

SE of aripiprazole

Answer 13

1) hyperprolactinemia
2) hypercholesterolemia,
3) akathisia (impulsive movements – more severe than that of typicals and atypicals)

Question 14

what are positive symptoms of psychosis?

Answer 14

auditory hallucinations, thought disorders,
delusions,
talking aloud

Question 15

what are negative symptoms of psychosis?

Answer 15

lack of interest,
social withdrawal,
catatonia (lack of motivation to move)

Question 16

what is classed as psychosis?

Answer 16

schizophrenia,
bipolar,
major depressive disorder