Depression

Question 1

What 2 drugs gave the idea that depression is due to lack of monoamine transmission?

Answer 1

1) Reserpine depletes monoamines: caused depression in some patients
2) Iproniazid prevents monoamine metabolism: caused euphoria

Question 2

what is ECT (Electroconvulsive Therapy)

Answer 2

is a treatment that involves sending an electric current through the brain to trigger an epileptic seizure to relieve the symptoms of some mental health problem.

The treatment is given under a general anaesthetic and using muscle relaxants, so that your muscles only twitch slightly, and your body does not convulse during the seizure.

Question 3

Moclobemide

Answer 3

Selective MAO-A inhibitor

Question 4

Phenelzine

Answer 4

Non-selective MAO inhibitor

Question 5

Imipramine

Clomipramine

Answer 5

Tricyclic antidepressants - NOR and 5-HT reuptake inhibitor

(but only clomipramine has any appreciable 5-HT effect

Question 6

Fluoxetine

Answer 6

Selective reuptake inhibitors –Serotonin

Question 7

Maprolitine

Answer 7

Selective reuptake inhibitors –NOR

Question 8

Venlafaxine

Answer 8

Selective reuptake inhibitors –NOR and Serotonin

Question 9

Mirtazepine

Answer 9

Selective reuptake inhibitors –NOR

alpha-2 antagonist (pre-synaptic receptor)

Question 10

Trazodone

Answer 10

Selective reuptake inhibitors – Serotonin

5-HT2 antagonist

Question 11

Rolipram

Answer 11

PDE-4 inhibitor

Question 12

SEs of tricyclic antidepressants

Answer 12

anti-histamine,
anti-muscarinic,
anti- α1 effects

Question 13

major SE of SRI?

Answer 13

loss of libido,
rash
GI side effects

Question 14

pharmacology of anti-depression drugs

Answer 14

therapeutic lag of a few weeks before effects are seen.

other long-term changes in the density and affinity of neurotransmitter receptors in the brain regions.