Pharm of the CNS (3)

Question 1

effect of GABA on GABAa receptors?

Answer 1

directly cause Cl- influx, leading to hyperpolarisation

Question 2

effect of GABA on GABAb receptors?

Answer 2

receptors cause via 2nd messenger potassium efflux, leading to hyperpolarsation

reduced Ca2+ influx.

Question 3

effect of glycine on glycine receptors?

Answer 3

cause directly Cl- influx, causing hyperpolarisation.

Question 4

perampanel

Answer 4

AMPAR antagonist

Question 5

Memantine/Ketamine

Answer 5

NMDAR antagonist

Ket- anti depressant effects

Question 6

Phenobarbitone

Answer 6

GABAa agonist

Question 7

Ecstacy?

Answer 7

like amphetamine, but for 5HT

Question 8

how are actions of NTs terminated?

Answer 8

re-uptaken

except- Ach and peptides: are broken down

Question 9

Fluoxetine

Answer 9

5HT uptake inhibitor

Question 10

ritalin

Answer 10

selective NOR and DOP uptake inhibitor

Question 11

amytriptyline

Answer 11

selective NOR and 5HT uptake inhibitor

Question 12

examples of positive CNS disorders?

Answer 12

1. pain
2. epilepsy
3. anxiety
4. schizo (positive symptoms)

Question 13

examples of negative CNS disorders?

Answer 13

1. depression
2. parkinsons
3. alzihmers
4. schizo (negative symptoms)

Question 14

what is the aim in treating depression?

Answer 14

increase NOR and 5-HT function

prozac – SSRI, or tricyclic – NOR and 5-HT reuptake inhibitor

Question 15

what is the aim in treating anxiety?

Answer 15

increase GABAa function

(diazepam - benzodiazepines)

and inhibitory 5-HT function (buspirone – partial agonist of 5-HT1 receptor)

Question 16

what is the aim in treating Schizophrenia?

Answer 16

reduce DOP function (haloperidol – D2 antagonist mainly)

Question 17

what is the aim in treating Parkinson’s

Answer 17

increase DOP activity (levodopa – precursor of DOP and other compounds to block breakdown)