Psychopharm Flashcards

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1
Q

What foods are high in serotonin

A
turkey 
tomatoes 
sunflower seeds 
avocados 
pineapples
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2
Q

When giving SSRI’s what bad reaction shoudl we monitor fo r

A

serotonin syndrom

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3
Q

What are the mani’s of serotonin syndrome

A
altered LOC
sweating  
fever
Tachycardia 
HTN 
hyperreflexia 
Diarrhea
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4
Q

Treatment for serotonin syn

A

Stop medication
Provide IV fluids
Cooling blankets
Antipyretics

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5
Q

What things increase risk of serotonin syn

A

MAOIs
TCA’s
St. Johns wort

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6
Q

What is a consideration for someone taking MAOIs and is starting SSRI’s or bupropion

A

discon the MAOI’s 14 days prior to starting the SSRI’s or bupropion

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7
Q

What medication do SSRI’s increase

A

warfarin

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8
Q

What medications increase SSRI levels

A

TCA’s

lithium

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9
Q

Do NSAIDS and anticoag’s taken with SSRI’s increasse risk fo bleeding

A

yes

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10
Q

What are TCA’s

A

tricyclic antidepressents

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11
Q

What do TCA’s do

A

inhbiit reuptake of serotonin and norepinephrine

sometimes blocks histamine and acetylcholine

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12
Q

What are some common side effects of TCA’s

A
anticholinergic effects like 
dry mouth
photophobia 
blurred vision 
constipation
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13
Q

What are some serious side effects of TCA’s

A

cardia toxicity

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14
Q

What are some examples of TCA’s

A

amitriptyline

Amoxapine

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15
Q

What is a consideration with MAOI’s and TCA’s

A

severe HTN is a risk so dont take together

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16
Q

What medications are contraindicated with TCA’s

A
antihistamines 
opioids
benzodiazepines
alc
MAOI's
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17
Q

What problems does TCA’s and opioids benzodiazepines alc cause

A

increased CNS depression

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18
Q

What do MAOI’s do

A

MAOIs increases the availability of norepinephrine dopamine, and serotonin

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19
Q

What foods should you avoid with MAOI’s and why

A
aged cheese 
red wine 
soy sauce 
salami 
bananas 
sauerkraut
bec they have tyramine or tryptophan
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20
Q

What are some common side effects of MAOI’s

A
anticholinergic effects like 
dry mouth
photophobia 
blurred vision 
constipation 
anx 
orthostatic hypotension
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21
Q

What is a serious side eff of MAOI’s

A

HTN crisis

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22
Q

What are some examples of MAOI’s

A

isocarboxzid
phenelzine
Tranylcypromine

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23
Q

What is a consideration with MAOI’s and antihypertensives

A

hypotension may develop

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24
Q

What should you do for MAOI and antihypertensive pats

A

monitor BP and notify MD of significant drop

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25
Q

What analgesic may cause hyperpyrexia when given with MAOIs

A

meperidine

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26
Q

What food may increase the risk of HTN with MAOI’s and why

A

caffeine and phenylethylamine

bec they cause vasoconstriction

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27
Q

What conditions is bupropion contraindicated

A
pregnancy
seizure disorders
MAOIs
anorexia nervosa
bulimia nervosa
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28
Q

What classes of meds are given as anti anx

A

benzodiazepines,
barbiturates,
beta-blockers

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29
Q

What are some common SE of anti anx meds

A

sedation
confusion
tolerance

30
Q

What are some short acting benzodiasepine s

A

lorazepam
oxazepam
alprazolam

31
Q

What are some long acting benzo’s

A

diazapam

chlordiazepoxide

32
Q

What are some short acting barbiturates

A

methohexital

thiopentone

33
Q

What are some long acting barb’s

A

phenobarbital

amobarbital

34
Q

What are some common SE of mood stabilizers (antimanics)

A

sedation
WeightG
GI distress
thristiness

35
Q

What are some serious SE of mood stabilizers

A

hepatotoxicity

36
Q

What are some mood stabilizers

A

lithium
valporic acid
Carbamazepine

37
Q

How long does lithium take to start workign

A

5-7 day s

38
Q

What is the care for pats takign lithium

A

Get lab lev after 12hours of first dose - Hold until lab levels are confirmed
monitor for sign of toxiciity
labs ev 2-3 days for therapeutic levels
labs ev 1-3 months for maintenance level
monitor sodium levels and signs of dehydration
Dont skimp on dietary sodium
drink 6-8 glasses of water per day
use cautiously with heart and renal pats

39
Q

What are the early signs of lithium tox (less than 1.5mEq/L)

A

dia
N/V
polyuria
mus weakness

40
Q

What are some signs of lithium tox from 1.5 to 2 mEq’s

A

confusion
tremors
poor coordination

41
Q

What are some signs of lithium tox from 2-2.5 mEq’s

A

extreme polyuria
tinnitus
seizure coma death

42
Q

What is the therapeutic level of lithium

A

0.5-1.5

43
Q

What is some teaching for lithium meds

A

category D preg risk

so no breast feeding when taking it

44
Q

What is a consideration for starting carbamazepine

A

Monitor blood levels weekly for the first 8 weeks

45
Q

What are some CNS stimulants

A

amphetamine

methylphenidate

46
Q

What are antipsychotics used to treat

A
hallucinations
nightmares 
delusions
paranoia 
agitation
alt ment stat
47
Q

What are some SE of first gen or conventional antipsychotics

A

extrapyrimidal effects like
Dystonia- sudden mus spasms of the eyes back and neck
restlessness (akathesia)
parkinsons like problems liek pill rolliing tremors and shuffling gait
tardive dyskinesia: involuntary movements like lip smacking chewing tongue protrusion

48
Q

What is usu given for dystonia from antipsycho’s

A

benadryl or benztropine

49
Q

What is usu given for restlessness from antipsycho’s

A

lorazepam

50
Q

When does dystonia, akathesia, and pseudoparkinsonism from antipsycho’s set in

A

4hrs for dystonia
4 weeks for pseudoparkisonisms
4 weeks akathesia

51
Q

What is a common ending for 1st gen antipsychotics

A

azine

52
Q

What type of med class is hadol and how strong is it

A

antipsychotic and its one of the strongest

53
Q

Bec antipsychotics effect dopamine what hormone is affected and what are some conditions taht can result from this inference

A

prolactin doesnt get inhibited

galactorrhea and gynecomastia

54
Q

What are some advantages of second gen antipsycho’s

A
High tolerability rate
Reduction of negative symptoms
Lower rate of relapse
Improve cognition with schizophrenia
Decrease suicidal thoughts
Decrease anxiety and depression
less chance of ExtraPyr SE 
doesnt cause galactorrhea
55
Q

What are some disadvantages of second gen antipsycho’s

A

Metabolic dysregulation leading to diabetes
High cholesterol and cardiac disease
Hypertension
Low self image

56
Q

What might be given prophylactically with pats who are receiving second gen antipsycho’s

A

metformin

57
Q

Why is low self esteem a problem with 2nd gen antipsychs and what do we educate for it

A

weight gain is common

exercise

58
Q

What are some common SE of second gen antipsycho’s

A

Weight G
sedation
hypersalivation
anticholernegic effects

59
Q

What are some serios SE of 2nd gen antipsych

A

neuroleptic malignant syndrome

sudden death from QT prologation from ziprasidone quetiapine

60
Q

What are some 2nd gen antipsych

A

clozapine
risperidone
quetiapine

61
Q

What type of patient is clozapine helpful

A

suidcidal schizophrenia pats

62
Q

What 2nd gen antipsych still has the risk of increased prolactin

A

risperidone

ziprasidone

63
Q

What med is given to treat pseudoparkinsonism

A

amantadine

64
Q

What med might be given to counteract the low dopamine levels from first gen antipsychs

A

levodopa

65
Q

mani’s of neuroleptic malignant syndrome

A
fever >103
HTN
tachycardia 
mus rigidity 
elevated Creatine Kinase (CK) and WBC levels
66
Q

What are the mani’s of serotonin syndrom e

A
fever
HTN
tachycardia
hyper reflexia 
diarrhea
67
Q

What is the treatment for NMS

A

discon the med
mon vital signs
meds for fever
transfer to ICU

68
Q

What is the fisrt choice med for NMS and why

A

bromocryptine

bec it reduces fever and hypertonia

69
Q

What med is given to reduce muscle breakdown in NMS pats

A

dantrolene

70
Q

What is a consideration for a NMS pat that was taking decanoate

A

they may be in recovery for 7-10 days

71
Q

What are the meds for tardive dyskinesia

A

none so far so advocate for less meds

72
Q

What are some side effects of anticonvulsants

A

NV
drowsiness or dizziness
blood problems
risk of suicide