Psychopathology Flashcards
What are the two approaches?
Clinical diagnostic
Empirical quantitative
Clinical diagnostic approach
Discrete categories defined on the basis of criteria proposed by expects (DSM-V)
Qualitative, used by professionals
Empirical quantitative approach
Assessed on a continuous scale, disorders at the extreme end of the distribution, indicates some may be more severe
Classification of psychopathologies
Internalising - depression, anxiety
Externalising - conduct problems, ADHD
Why are we interested in it?
It is a major public heath issue, 1 in 4 girls, 1 in 8 boys
Very common/prevalent - 10-25% depending on country
Early onset, 75% occur before 25
Chronic - high chance it will come back
Important period for prevention and intervention
How do we study nature and nurture?
Not possible to disentangle both but twin and adoption designs help make estimation of which
Twin designs
Compare similarity of MZ and DZ twins on a specific trait, allowing us to get a rough estimate of separate genetic and environmental contributions
MZ twins result from 1 fertilised egg, so 100% similar
DZ - 2 eggs, 50% similar
What are the components of phenotypic variation
Heritability H2 or A - genes
Shared environment C, c2 - only environmental influences that contribute to similarity of twins
Non shared environment E e2 - only aspect of environment that makes twins different
Why we study nature and nurture?
Need to understand origins and cause, to then identify who would be predicted to get it, treatment, prevention and risk reduction interventions
What is the equation for phenotypic variation?
P = H2 + C2 + E2
How to estimate H?
2(rMZ - rDZ)
How to estimate C?
rMZ - h2
How to estimate E?
1-rMZ
ACE model
ACE all explain the variance in a trait
components can be measured using structural model fitting analyses
What disorders are highly heritable?
Bipolar Schizophrenia Alzeimers Cocaine Anerexia Substance use: drugs, cannibis, alcohol ADHD - 90%