Psychological Aspects of Chronic Pain and Disability

Question 1

What medications can be prescribed for neuropathic pain in Diabetes? (3)

Answer 1

1st Line = Duloxetine (SNRI).
2nd Line = Gabapentin.
2nd Line = Pregabalin.
Other = Capsaicin Cream.

Question 2

What is the mechanism of action of Gabapentin and Pregabalin?

Answer 2

A-2-D Ligand Antiepileptic Drugs : related to presynaptic inhibition of the release of excitatory neurotransmitters e.g. Glutamate.