Psychiatry Flashcards

1
Q

What are some risk factors for bipolar disorder? x6

A

no single cause

  • genetic factors (SNPs)
  • prenatal exposure to Toxoplasma gondii
  • premature birth <32 weeks gestation
  • childhood maltreatment
  • postpartum period
  • cannabis use
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the clinical features of bipolar II and II?

A

Bipolar I - at least one episode of mania
Bipolar II - at least one episode of hypomania, but never an episode of mania. Also at least one episode of major depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the characteristic clinical features of a manic episode?

A

Lasting for at least seven days and have a significant negative functional effect on work and social activities

Elevated mood excessive to circumstance
Elation with increased energy –> overactivity, pressure of speech, decreased need for sleep
Inability to maintain attention, often with marked distractibility
Inflated self-esteem with grandiose ideas of self-importance
Loss of normal social inhibitions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some differentials for bipolar disorder? x6

A

Schizophrenia
Organic brain disorder
Drug use
Recurrent depression
Emotionally unstable personality disorder (EUPD)
Cyclothymia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the acute management of mania?

A

secondary care management with oral antipsychotics:
- haloperidol
- olanzapine
- quetiapine
- risperidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What medications are used in the acute management of depression in bipolar disorder?

A

Fluoxetine + olanzapine
Quetiapine alone
Olanzapine alone
Lamotrigine alone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the long-term management for bipolar disorder?

A

Mood stabilising medications e.g. lithium

2nd line Sodium valproate (NOT in pregnant women)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some potential complications of bipolar disorder? x4

A

increased risk of death by suicide
increased risk of death by general medical conditions such as cardiovascular disease
side effects of antipsychotics
socioeconomic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the 3 categories of personality disorders?

A

anxious
suspicious
emotional or impulsive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are some examples of anxious personality disroders?

A

Avoidant - severe anxiety about rejection and avoidance of social situations/relationships

Dependent - heavy reliance on others to make decisions and take responsibility for their lives

Obsessive compulsive - unrealistic expectations of how things should be done by themselves and others, catastrophising

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the types of suspicious personality disorders?

A

Paranoid - difficulty trusting others

Schizoid - lack of interest or desire to form relationships with others

Schizotypal - unusual beliefs, thought and behaviours, as well as social anxiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the types of emotional/impulsive personality disorders?

A

Borderline - fluctuating strong emotions and difficulties with identity and maintaining healthy relationships

Histrionic - need to be centre of attention, having to perform to maintain that attention

Narcissistic - feeling that they are special and need other to recognise this

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are personality disorders?

A

Personality disorder (PD) is an umbrella term that covers a number of variations of maladaptive personality traits that cause significant psychosocial distress and interfere with everyday functioning.

characterised by patterns of thought, behaviour and emotions which differ from what is normally expected by society

leads to difficult relationships, reduced quality of life and poor physical health

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the 3 main categories of personality disorders according to the DSM-5?

A

Cluster A - Suspicious
Cluster B - emotional or impulsive
Cluster C - anxious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the management strategies for personality disorders?

A

Risk management (mainly harm to self and others)

Psychological treatment - CBT, DBT (dialectal behaviour therapy)

Medications are not recommended for long term treatment however sedative medications are sometimes used in a crisis short-term

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is post-traumatic stress disorder?

A

a mental health condition resulting from traumatic experiences, with ongoing distressing symptoms and impaired function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are some examples of traumatic events which may result in PTSD?

A

violence e.g. sexual assault, domestic violence, abuse
major car accidents
major health events e.g. traumatic childbirth, serious illness or death of a loved one
natural disasters
military, combat and war zones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are some of the key symptoms of PTSD x10

A

intrusive thoughts
re-experiencing (flashbacks, images, nightmares)
hyperarousal (feeling on edge, irritable and easily startled)
negative emotions
negative beliefs
difficulty with sleep
depersonalisation
derealisation
emotional numbing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How is PTSD diagnosed?

A

Trauma screening questionnaire

DSM-5
ICD-11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the management options for PTSD?

A

psychological therapy
eye movement desensitisation and reprocessing
Medication e.g. SSRIs, venlafaxine or antipsychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is obsessive compulsive disorder?

A

characterised by obsessions and compulsions

obsessions = unwanted and uncontrolled thoughts and intrusive images which the person finds difficult to ignore

compulsions = repetitive actions which the person feels they have to do

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the 4 steps of the OCD cycle

A
  1. Obsessions
  2. Anxiety
  3. Compulsion
  4. Temporary relief
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which diagnostic tools are used to confirm OCD diagnosis:?

A

DSM-5 and ICD-11

Yale-brown obsessive compulsive scale is used to assess the severity of symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the management options for OCD?

A

Mild cases can be managed with education and self-help resrouces

CBT with exposure and response prevention (ERP)
SSRIs
Clomipramine (TCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What are dissociative disorders?
when people feel a sense of disruption between their consciousness, body, perceptions, memories, identity and emotions which normally people experience as connected and integrated
26
What are 3 examples of dissociative disorders?
Depersonalisation-derealisation disorder Dissociative amnesia Dissociative identity disorder
27
What is catatonia? what causes it?
abnormal movement., communication and behaviour which can look like unusual postures, performing odd actions, repeating sounds or words or remaining blank and unresponsive most often caused by severe depression and bipolar disorder, rarely physical health conditions like strokes or brain tumours can lead to catatonia
28
What is reactive attachment disorder?
difficulty forming close relationships or attachments with poor response to affection or discipline as a result of severe neglect and trauma in early childhood
29
What is attachment theory?
The importance of creating healthy consistent and secure attachments to at least one nurturing individual during early childhood, particularly for the first 2 years of life
30
What is factitious disorder/Munchhausen syndrome?
where a conscious effort is made to fake illness and seek medical attention for personal gain symptoms are invented, exaggerated or induced to invoke attention, affection, relationships and care from others may have repeated presentations with inconsistent and dramatic symptoms which do not fit with examination and investigation findings
31
What is alien hand syndrome? cause?
where the patient loses control of one of their hands so that it acts independently usually the result of an underlying brain lesion such as brain tumours, injuries, aneurysms or following surgery
32
What is cotard delusion? causes?
The false belief that they are dead or actively dying also known as walking corpse syndrome most coften caused by psychiatric conditions like depression and schizophrenia but also can be caused by brain tumours and migraines
33
What is capgras syndrome?
false belief that an identical duplicate has replaced someone close to them
34
What is De Clerambault's syndrome?
also called erotomania false belief that a famous or high-social status individual is in love with them leading to inappropriate harassment of the individual by the patient frequently occurs without any other psychiatric or neurological disease
35
What is Alice in wonderland/Todd syndrome?
incorrectly perceiving the sizes of body parts or objects also associated with changes to the perception of time and symptoms of migraines causes include migraine, epilepsy, brain tumours
36
What is Koro syndrome/
a false belief that the sex organs are retracting or shrinking and will ultimately disappear resulting in anxiety and panic attacks has been linked to cultural beliefs in asia
37
What is body integrity dysphoria?
a strong feeling that a part of the body does not belong to them typically associated with a desire to removed that part of their body
38
What is foreign accent syndrome?
sudden change in a person's voice most commonly caused by a stroke in the left hemisphere
39
What is schizophrenia? at what age does it usually present?
a severe long-term mental health disorder characterised by psychosis often presents between age 15-30 and earlier in men than women symptoms must be present for at least 6 months before schizophrenia is diagnosed
40
What is schizoaffective disorder?
a combination of the symptoms of schizophrenia with bipolar disorder so patients have psychosis with symptoms of depression and mania
41
How is schizophreniform disorder different to schizophrenia?
presents with the same features as schizophrenia but lasts less than 6 months
42
What are some other causes of psychosis?
mania psychotic depression drugs stroke brain tumours cushing's syndrome hyperthyroidism huntington's disease
43
What causes schizophrenia?
thought to be a combination of genetic and environmental factors
44
How does schizophrenia typically present>
a prodrome phase with subtle symtpoms like poor memory, reduced concentration, mood swings, sleep disturbance etc. then the positive symptoms of psychosis including delusions, hallucinations and thought disorder lack of insight
45
What are some key positive symptoms seen typically in schizophrenia?
auditory hallucinations somatic passivity thought insertion or withdrawal thought broadcasting persecutory delusions ideas of reference delusional perceptions
46
What are the 4 A's which are negative symptoms of schizophrenia?
affective flattening alogia (reduced speech) anhedonia avolition (lack of motivation in working towards goals or completing tasks)
47
What are the different patterns of schizophrenia that can be observed over time?
continuous episodic single episode only
48
How is a diagnosis of schizophrenia made?
used the DSM-5 criteria symptoms must have been present for at least 6 months with active phase symptoms present for at least one month
49
What is the management for schizophrenia?
antipsychotic medications cognitive behavioural therapy
50
What are some examples oral antipsychotics?
chlorpromazine haloperidol quetiapine aripiprazole olanzapine risperidone
51
What are some examples of depot antipsychotics?
helpful where adherence may be an issue aripiprazole flupentixol paliperidone risperidone
52
What are some key complications of clozapine use?
agranulocytosis myocarditis or cardiomyopathy constipation seizures excessive salivation
53
What 4 monitoring requirements are required before starting and during antipsychotic treatment ?
Weight and waist circumference Blood pressure and pulse rate Bloods, including HbA1c, lipid profile and prolactin ECG
54
WHat are 5 side effects of antipsychotic drugs?
Weight gain Diabetes Prolonged QT interval Raised prolactin Extrapyramidal symptoms
55
What are some extrapyramidal side-effects of antipsychotic drugs?
Akathisia (psychomotor restlessness, with an inability to stay still) Dystonia (abnormal muscle tone, leading to abnormal postures) Pseudo-parkinsonism (tremor and rigidity, similar to Parkinson’s disease) Tardive dyskinesia (abnormal movements, particularly affecting the face)
56
What is an illusion?
False perception of real, existing sensory stimulus
57
What is a hallucination?
False sensory experience when there is no stimulus present, can be visual, auditory, olfactory, tactile or gustatory
58
What is a delusion?
A false belief that is firmly held despite contradictory evidence.
59
What is an overvalued idea?
An unreasonable and sustained belief that is maintained with less than delusional intensity (i.e. the person is able to acknowledge the possibility that the belief may or may not be true)
60
What is thought alienation?
A symptom of psychosis which occurs when someone feels that their thoughts are no longer under their control. Can include thought insertion, broadcasting, withdrawal
61
What is thought insertion?
When a person feels that thoughts are being spoken to them or are occurring outside of their mind, but they recognize that they are the one thinking them
62
What is thought withdrawal?
When a person feels that their thoughts have been taken out of their mind and they have no power over this.
63
What is thought broadcast?
A type of thought alienation where the person believes that others are able to read their thoughts.
64
What is thought echo?
A symptom of psychosis where someone hears their own thoughts being spoken aloud, shortly after thinking them.
65
What is thought block?
A neuropsychological symptom expressing a sudden and involuntary silence within a speech, and eventually an abrupt switch to another topic.
66
What is concrete thinking?
Reasoning which is based on what you can see, hear, feel and experience in the here and now. Also called literal thinking, because it focuses on physical objects, immediate experiences and exact interpretations.
67
What is loosening of association?
Also known as derailment. A thought process disorder which is characterised by a lack of connection between ideas. Speech is vague and confusing.
68
What is circumstantiality? How is it different to tangentiality?
Circumstantiality is circuitous and non-direct thinking or speech that digresses from the main point of a conversation but is still linked to the topic. Whereas tangentiality is where the person strays very far from the main point they're trying to make and don't reach a main point or answer questions.
69
What is perseveration?
The repetition of a particular response (word, phrase or gesture) regardless of the absence or cessation of a stimulus.
70
What is confabulation?
A neuropsychiatric disorder wherein a patient generates a false memory without realising it's not true. Sometimes called "honest lying".
71
what is somatic passivity?
Experience of bodily sensations (thoughts, actions, emotions) imposed by external agency. e.g. voices commenting on one's actions
72
What is delirium?
A mental state of confusion and disorientation which can develop suddenly and is often temporary
73
What is catatonia?
A state of apparent unresponsiveness to external stimuli and apparent inability to move normally in a person who is apparently awake.
74
What are some common behavioural responses to stimuli seen in catatonia?
Mutism (absence of speech) Negativism (performing actions contrary to the commands of the examiner) Echopraxia (repeating the movements of others) Echolalia (repeating the words of others) Waxy flexibility (slight, even resistance to positioning by examiner) Withdrawal (absence of responses to the environment)
75
What is psychomotor retardation?
The slowing down or hampering of mental or physical activities
76
What is flight of ideas?
A thought disorder which refers to rapid and erratic speech that jumps from one topic to another.
77
What is poverty of speech?
Also known as alogia, a speech disturbance which involves a reduction in the amount and quality of speech.
78
What is poverty of thought?
a thought disorder characterised with a reduction in thought spontaneity and productivity, and vague or repetitive speech sometimes called intellectual impoverishment
79
What is anhedonia?
A symptom of many mental health conditions which refers to the inability to feel pleasure or joy
80
What is flattening of affect?
A clinical sign where the person has reduced or absent displays of emotion
81
What is incongruity of affect?
When the person's emotional demeanor doesn't match what's happening around them.
82
What is blunting of affect?
decreased ability to express emotion through facial expressions, tone of voice and physical movements.
83
What is belle indifference?
A paradoxical absence of psychological distress despite a serious medical illness or symptoms of a health condition.
84
What is depersonalisation?
When the person feels disconnected from their body, feelings and environment
85
What is derealisation?
A mental state where you feel detached from your surroundings and people and objects may seem unreal.
86
What is conversion?
Conversion is a defense mechanism by which individuals reduce acute anxiety by converting psychological suffering into physical symptoms.
87
What is dissociation?
A mental process where a person disconnects from their thoughts feelings, memories or sense of identities
88
What is stereotypy?
a seemingly purposeful, coordinated, but involuntary, repetitive, ritualistic gesture, mannerism, posture, or utterance e.g. repetitive grimacing, lip smacking etc.
89
What are mannerisms?
Strange or bizarre ways of carrying out normal activities
90
What is an obsession?
a persistent, unwanted, and intrusive thought, urge, or image that causes anxiety, distress, or unease.
91
What is a compulsion?
a repetitive behaviour or mental act that a person feels driven to perform in response to an obsession
92
What are the 3 core behaviours of ADHD?
1. Hyperactivity. 2. Inattention. 3. Impulsivity. (HII) These symptoms occur in every child from time to time but when they are persistent and impact on daily functions, more investigation is needed
93
ADHD core behaviours: give 3 signs of impulsivity.
1. Blurts out answers. 2. Interrupts. 3. Difficulty waiting turns. 4. When older, pregnancy and drug use.
94
ADHD core behaviours: give 3 signs of inattention.
1. Easily distracted. 2. Not listening. 3. Mind wandering. 4. Struggling at school. 5. Forgetful. 6. Organisational problems. Does not appear to be listening when spoken to directly Makes careless mistakes Looses important items
95
What is the diagnostic criteria for ADHD? According to DSM-5 *(Diagnostic and Statistical Manual of Mental Disorders)*
**ADHD definition <17 Years** 6/9 inattentive symptoms and 6/9 hyperactivity/impulsivity. Present before 12 years Developmentally inappropriate Several symptoms in 2 or more settings Clear evidence symptoms interfere/reduce the quality of social/academic/occupational function .
96
Describe the nn pharmalogical treatment for ADHD.
1. Education. 2. Parenting programmes and school support. Behavioural interventions, e.g. encouraging realistic expectations, positive reinforcement of desired behaviours (small immediate rewards), consistent contingency management across home and school, break down tasks, reduce distraction. Implementing Routines Evidence base for fish oils in diet Learning support
97
What are some medicine for ADHD?
Methylphenidate (ritalin, concerta, Equasym) Atomoxetine (Strattera®) A non-stimulant NE reuptake inhibitor licensed for the treatment of ADHD.
98
What are some things you need to consider/ SE of ADHD medication?
headache, insomnia, loss of appetite, stomach ache, dry mouth, nausea Can stunt growth Need to Monitor weight, height and BP Methyphenidate is Not recommended to take during pregnancy
99
What are the 3 main features of the deficits seen in ASD?
They can be categorised as deficits in social interaction, communication and behaviour
100
Outline some social interaction issues often seen in those with ASD
NO DESIRE TO INTERACT WITH OTHERS BEING INTERESTED IN OTHERS TO HAVE NEEDS MET LACK OF MOTIVATION TO PLEASE OTHERS AFFECTIONATE ON OWN TERMS Touches inappropriately Poor Eye contact Plays alone Finds it stressful to be with other people
101
Outline some communication issues often seen in those with ASD
Repetitive use of words or phrases Delay, absence in language development Lack of appropriate non-verbal communication such as smiling, eye contact, responding to others, and sharing interest Lack of desire to communicate at all PEDANTIC LANGUAGE, VERY LITERAL, POOR OR NO UNDERSTANDING OF IDIOMS AND JOKES
102
Outline some behavioural issues seen in Autism
USING TOYS AS OBJECTS INABILITY TO PLAY OR WRITE IMAGINATIVELY RESISTING CHANGE PLAYING SAME GAME OVER AND OVER OBSESSIONS/RITUALS There may be self-stimulating movements that are used to comfort themselves, such as hand-flapping or rocking. Extremely restricted food preferences
103
Describe the treatment for ASD.
- Education and games to encourage social communication. - Visual aids and timetables. - Parenting workshops and school liaison. Manage Comorbidity There are no medications available for ASD Diagnosis should be made by a specialist in autism. This may be a paediatric psychiatrist or paediatrician with an interest in development and behaviour. A diagnosis can be made before the age of 3 years. It involves a detailed history and assessment of the child’s behaviour and communication..
104
What are some risk factors for depression?
Prior depression Family Hx depression Female Hx abuse Drug and alcohol use Low socioeconomic status Recent bereavement, stress or medical illness, traumatic life event Co-existing medical conditions (chronic disease)
105
What are the 3 key symptoms of depression?
Low mood Loss of energy (anergia) Anhedonia (loss of enjoyment of formerly pleasurable activities)
106
What are some things you may find on consulation/examination/investigations for depression?
Carry out mental state examination - **Appearance may be normal**, or evidence of self beglect. substnace abuse, tearfulllness, anxious, fidegty **Speach may be monotonic and slow** - patient may appear distracted **Psychotic features** - eg auditory hallucinations, loss of insight Baseline tests for FBC and TFT may be useful for ruling out anaemia and hypothyroidism, that can lead to depression
107
What is the name of the questionaire used in depression?
The Patient Health Questionnaire-9 (scored out of 27) is used to grade depression – It asks patients to report over the last 2 weeks how often they have been experiencing symptoms – Made of 9 items which is scored from 0-3 – Mild = 5-9 – Moderate = 10-14 – Moderate/Severe = 15-19 – Severe = >19
108
What is the non pharmalogical measurements for mild depression?
Mild depression * Watchful waiting (GP monitoring progress post diagnosis) * Guided self-help: workbook/online course + therapy support * Exercise * Talking therapies - CBT, interpersonal therapy (IPT), psychodynamic psychotherapy ○ CBT: § Aim to help understand thoughts/behaviour + how they affect you § Recognises events in past but concentrates on how can change thinking/feeling/behaviour in present § Available on NHS for depression/mental health problems ○ IPT: § Focus on relationships with others and problems within them § E.g. issues with communication, coping with bereavement
109
What is the treatment for moderate/severe depression?
Moderate/severe depression * Antidepressants (SSRIs, TCAs) - continued for 6+ mths after Sx stop * Combination therapy e.g. meds + talking therapy SSRI - Selective serotonin reuptake inhibitors eg Sertraline, paroxetine, fluoxetine, citalopram *Fluoxetine 1L in children* TCAs (Tricyclic antidepressants): Imipramine, amitriptyline SNRIs (Serotonin-noradrenaline reuptake inhibitors): Venlafaxine, duloxetine, Mirtazapine
110
What is some treatment for very severe depression
Resistant depression Tx w/ combo of antidepressants + Lithium Atypical antipsychotic Another antidepressant ECT very effective in severe cases (Electroconvulsive Therapy)
111
Outline what bipolar disorder consists of - what is the ICD-10 definition
Bipolar affective disorder - recurrent episodes of altered mood and activity Involving upswings and downswings (hypomania/mania + depression) Hx of **2 mood disorders,** at least one: Hypomania < 4d Mania >7 d
112
What are some things you might see in an episode of hypomania? How long do these tend to last?
Lasts about 4 days Elevated mood Increased energy, talkativeness Poor concentration Mild reckless behaviour (overspending) Sociability/overfamiliarity Increased libido/sexual disinhibition Increased confidence Decreased need to sleep Change in appetite
113
Types of bipolar - outline what is seen in cyclothymia - What differentiates mania from hypomania?
Cyclothymia - chronic mood fluctuations over 2+ yrs, episodes of depression and hypomania (not mania). Rapid cycling, episodes only lasting few days **presence of psychotic Sx e.g. auditory hallucinations/grandiose delusions differentiates mania from hypomania
114
What are some differentials that you need to rule out in bipolar disorder?
Substance abuse (amphetamines, cocaine) Endocrine disease - Cushing's, steroid-induced psychosis Schizophrenia Schizoaffective disorder - Dx when affective and first rank schizophrenic Sx equally prominent Personality disorders - emotionally unstable, histrionic ADHD in younger people
115
What are some side effects of lithium
L - leukocytosis I - insipidus diabetes (nephrogenic) T - tremors (if coarse, think toxicity) H - hydration (easily dehydrates, need to drink lots, is renally cleared) I - increased GI motility U - underactive thyroid M - metallic taste (warning of toxicity), mums beware - teratogenic Lithium + diuretics -> dehydration Lithium + NSAIDs -> kidney damage & weight gain, hypothyroidism
116
What are some other conditions you would want to do to rule out other causes of symptoms seen in GAD?
depression and obsessive compulsive disorder Hyperthyroidism - do TFTs Pheochromocytoma Lung disease - excessive salbutamol use Congestive HF - heart meds -> anxiety Hypoglycaemia Do Bloods, and BP
117
What are some risk factors/causes of developing GAD?
Family Hx anxiety Physical/emotional stress Financial, bereavement etc Hx physical/sexual/emotional trauma (in childhood) Excessively pushy parents in childhood Other anxiety disorder - coexisting depression Chronic physical health condition Worries about physical health Female 2:1 Male Environmental triggers/contributors: family relationships, friendships, bullies, school pressures, alcohol and drug use e.g. benzodiazepines
118
What is the non pharmalogical management of GAD?
Mild anxiety can be managed with watchful waiting and advice about self-help strategies (e.g. meditation), diet, exercise and avoiding alcohol, caffeine and drugs. Moderate to severe anxiety can be referred to CAMHS services to initiate: Counselling Cognitive behavioural therapy
119
What are some common phobias? What causes them?
animals (spides, snakes, worms) Blood/injection/injury Situational (lifts, flying, enclosed space) Natural environment (storms, heights, water) Other: choking, vomiting, clowns Amygdala, anterior cingulate cortex and insula hyperactivity involved in underlying mechanism of action
120
What are the 3 types of Phobias?
Simple phobia Inappropriate anxiety in the presence of ≥1 object/situation, e.g. flying, enclosed spaces, spiders Social phobia Intense/persistent fear of being scrutinized or negatively evaluated by others leads to fear and avoidance of social situations (e.g. using a telephone, speaking in front of a group). Agoraphobia fear of fainting and/or loss of control are experienced in crowds, away from home, or in situations from which escape is difficult. Avoidance results in patients remaining within their homes where they know symptoms will not occur.
121
What are the general treatments for phobias?
For simple phobias - Treatment is only needed if symptoms are frequent, intrusive, or prevent necessary activities. Exposure therapy is effective. For social and agoraphobia - drug therapy SSRIs, and TCAs eg **Clomipramine** Psychological therapies CBT (cognitive restructuring) +/- exposure
122
Outline some neuropathology that is thought to be linked to GAD
Low levels of GABA, contribute to anxiety. Been seen that frontal cortex and amygdala undergo structural remodelling induced by the stress of maternal separation and isolation, which alters behavioural and physiological responses in adulthood. * Heightened amygdala activation occurs in response to disorder-relevant stimuli in post-traumatic stress disorder, social phobia and specific phobia Basically overfiring/activation of the amygdala
123
What is the pharmacological management of GAD?
SSRI (sertraline is first-line SSRI) – Be careful in young people as the SSRI increases anxiety initially and can lead to suicidal thoughts Pre-gabalin – If acutely anxious –> Benzodiazepine (but not for > 4 weeks) Beta blockers e.g. bisoprolol for physical Sx
124
Define PTSD
Post traumatic stress disorder Develop (immediately/delayed) post exposure to stressful event/threatening, catastrophic situation
125
What are some common causes of PTSD?
Serious accident e.g. RTA Witness of violence - school, domestic, torture, terrorist attack, rape Combat exposure Natural disaster Sudden death of loved one Multiple major life stressors
126
What are the clinical feautres of PTSD? How long must they be present for?
Symptoms – These must be present >1 month – Persistent intrusive thoughts and re-experiencing –> flashbacks, nightmares and intrusive images – Autonomic hyperarousal –> persistent activation gives startle, hypervigilance, insomnia – Avoidance –> patient avoids situations and stimuli associated with the event – Emotional detachment –> feeling detached from people and lack of ability to experience feelings – Higher risk of depression, substance misuse, unexplained physical symptoms
127
What are some non pharmalogical managements for PTSD
CBT - eg education about the nature of PTSD, selfmonitoring of symptoms, anxiety management, breathing techniques Eye movement desensitization and reprocessing (EMDR): Using voluntary multi-saccadic eye movements to reduce anxiety associated with disturbing thoughts Stress management Hypnotherapy
128
What are some pharmaogical managments for PTSD
SSRIs (e.g. paroxetine 20–40mg/day; sertraline 50–200mg/day) are licensed for PTSD, It may be helpful to target specific symptoms: * Sleep disturbance (including nightmares): may be improved by mirtazapine (45mg/day), * Anxiety symptoms/hyperarousal: consider use of BDZs (e.g. clonazepam 4–5mg/day), buspirone, antidepressants, propranolol. * Intrusive thoughts/hostility/impulsiveness: some evidence for use of carbamazepine, valproate, or lithium. * Psychotic symptoms/severe aggression or agitation: may warrant use of an antipsychotic (some evidence for olanzapine, risperidone etc)
129
What are some primary causes of insomia?
Fear/anxiety about falling asleep Change of environment (adjustment disorder) Inadequate sleep hygiene Idiopathic insomnia (rare, lifelong inability to sleep) Behavioural insomnia of childhood
130
What are some secondary causes of insomia?
Sleep-related breathing disorder e.g. sleep apnoea Circadian rhythm disorders Shift work REM behavioural disorder e.g. Lewy body dementia, PD Medication conditions causing pain -> awake Psychiatric disorders - depression (early morning waking), anxiety (early/middle insomnia) Drugs/alcohol - steroids, antidepressants, stimulants
131
What are some nonpharmacological management options for insomnia?
Encourage good sleep hygiene, routines Remove noise, light, and distractions Wind down before bed Avoid caffeine/stimulation Sleep restriction Prevent naps during day to promote sleeping @ night
132
What are some pharmalogical management options for insomnia?
Medication (once good sleep hygiene proved unsuccessful) Z drugs 1L - zopiclone, zolpidem, zapeplon Sedating antidepressants - mirtazepine Melatonin
133
What is paraphrenia?
psychotic illness characterized by delusions and hallucinations, without changes in affect (although there may be reactive anxiety), a form of thought, or personality. it's the most common form of psychosis in old age - aka late-onset schizophrenia
134
What are some things you'd see in paraphrenia?
*no evidence of dementia w/ later onset cases - no memory problems Delusions, hallucinations - often about neighbours Paranoid - often re. neighbours spying, taking things can also be misidentification, hypochondraical, religious Partition delusion - believe people/objects can go through walls Less -ve Sx (blunting/apathy) and formal thought disorder compared to early onset
135
What is the treatment steps in paraphrenia?
Relieve isolation and sensory deficits. Low-dose atypical antipsychotics preferred as elderly are very sensitive to side-effects, but non-compliance secondary to lack of insight is often an issue.
136
Broadly speaking, what is seen in a cognitive impairment?
Minor problems w/ cognition - mental abilities: memory, thinking Not severe enough to interfere w/ everyday life Mild cognitive impairment = pre-dementia condition in some people
137
What are some causes of a cognitive decline, particulary in the elderly?
Depression, anxiety, stress Sleep apnoea and other sleep disorders Physical illness (constipation, infection) Poor eyesight/hearing Vitamin/thyroid deficiencies e.g. Vit B12 SE of medication: CCBs, anticholinergics, benzodiazepines Drug/alcohol abuse Uncontrolled health conditions like high BP, high cholesterol, diabetes, obesity
138
What are the symptoms of cognitive decline?
Not severe enough to interfere w/ daily life -> not defined as dementia (dementia Dx = 2/more of problems with: memory, reasoning, language, coordination, mood, behaviour) Memory - forgetting recent events/repeating same question Reasoning, planning, problem solving - struggling to think things through Attention - v easily distracted Language - taking longer than usual to find right word for something Visual depth perception - struggling to interpret 3D object, judge distances, navigate stairs
139
What are some investigations for a cognitive decline
Take a thorough, collateral history Review of medications MSE Input from family/collateral Hx Bloods/urine if suspect infection/another clinical cause
140
What is the management for a cognitive impairment>
Prophylaxis/Mx of precipitative Sx: Poorly controlled heart condition/diabetes/strokes -> ^ risk MCI So control e.g. prevent high BP Medication management of depression/anxiety Good sleep hygiene Preparation for the future when memory may get worse Power of attorney etc
141
What are some causes of Psychosis, that can be differentials to schizophrenia?
Bipolar disorder – often may present with symptoms of schizophrenia Psychotic Depression Alcohol hallucinations, due to withdrawal Drugs - **especially Cannabis**, Cocaine, LSD, magic Mushrooms (Psilocybin) Dopamine Agonists, like Levo Dopa in Parkinsons Other health conditions, like Encephalitis Epilspeys (temporal lobe seizure,) Dementia, and Parkinsons B12 def, hypoglycaemia, Trauma Brief Psychotic disorder – symptoms are present for less than a month, then disappear.
142
What are some atypical anti psychotics, and how do they work?
Atypical anti-psychotics – work by blocking dopamine and serotonin: Quetiapine Olanzapine Risperidone Clozapine Aripiprazole Atypical are first line now (other than clozapine)
143
What are some typical anti-psychotics, and how do they work? When should they be tried?
Typical anti-psychotics – work by dopamine blockade (D2 receptors): Haloperidol Chlorpromazine
144
When should you trail clozapine as an antipsychotic? What do you need to do with it?
If two other anti-psychotics have not been effective, then clozapine should be considered. Second line – Clozapine – atypical antipsychotic – this is not included as a first line treatment, as requires close monitoring as it has a tendency to cause **aplastic anaemia,** which can be fatal. **If two other anti-psychotics have not been effective**, then clozapine should be considered. CPMS – Clozepine monitoring system. A national service in the UK, that gives advice on the drug dosage to use, depeninding on the blood test results you send to them. Compulsory for anyone on clozepine. Only consultant psychiatrists can prescribe clozapine
145
What checks need to be done regulary for people on antipsychotic medications?
ECG – as QTC prolongation can occur Glucose and lipids – antipsychotics can lead to diabetes and metabolic syndrome If on CLOZAPINE – regular FBCs to check for AGRANULOCYTOSIS
146
What are some other side effects of antipsyhcots?
Diabetes/insulin resistance and dyslipidaemia QT segment changes on ECG Agranulocytosis – clozapine Extra-pyramidal side effects due to the dopamine blockade - Urinary retention Blurred vision Dry mouth Weight gain Hyperprolactinaemia (due to dopamine blockade and dopamine down regulates prolactin)
147
What are some extra pyrimidial side effects of antipsycotics, and how can they be treated?
Acute dystonic reaction (hours) Muscle spasm, acute torticolis, eyes rolling back Parkinsonism (days) Tremor, bradykinesia Akathisia (days to weeks) “inner restlessness, pacing and agitated, often intolerable. They literally can’t stop moving e.g. shaking legs, touching table Massive RF for suicide in young males with schizophrenia Tardive dyskinesia (months to years) Grimacing, tounge protrusion, lipsmacking Very difficult/impossible to treat as you’ve upregulated all the D2 receptors These side effects are worse and more common in the older antipsychotics Treat with Procyclidine, an anticholinergic drug
148
What are some non pharmacological treatments of schizophrenia?
Individual CBT: normally consists of at least 16 one-on-one sessions. It helps patients create links between their thoughts, feelings and actions with their experience of schizophrenia. Family intervention: should include the patient suffering from schizophrenia if possible as well as their main carer. Normally consists of 10 sessions over 3 months - 1 year. Art therapies can be particularly helpful for negative symptoms. Self-help groups and forums (e.g. Hearing Voices groups) enable people with psychosis to share experiences and ways to cope with symptoms This should be done alongisde antipyscotic
149
Outline some differential diagnosis for medically unexplainable symptoms
Factitious, symptoms are fabricated and not experienced as real by the patient Somatoform disorder - Symptoms are unconsciously generated by the mind, but experienced as real by patient Undiagnosed - symptoms are arising from a physical cause that hasn't been identified yet
150
Give the definition of personality
The characteristics and relatively permanent sets of behaviours, cognitions, and emotional patterns that evolve from biological and environmental factors ‘Characteristic lifestyle and mode of relating to others’ (ICD – International Classification of Diagnosis)
151
What is Charles - Bonnet Syndrome? What conditions are known to cause it
Complex visual hallucinations in a person with partial or severe blindness (macular degeneration, diabetic retinopathy) Patients understand that the hallucinations are not really and often have insight compared to other disorders For those experiencing CBS, knowing that they have this syndrome and not a mental illness seems to be the most comforting treatment so far, as it improves their ability to cope with the hallucinations.
152
Outline what is seen in Muchausens syndrome
This is a condition where patients will produce physical or psychological symptoms to attain a patient’s role – Patients can feign the symptoms, exaggerate them or deliberately hurt themselves to produce symptoms – Typically, patients take hallucinogens, inject faeces to make abscesses and contaminate urine samples.
153
Outline what is seen in malingering
Malingering (FINANCIAL GAIN) This is when a patient feigns or exaggerates their symptoms purely for a financial reward or other gain. – Unlike Munchanhausen syndrome, it is not to play a patient’s role but to **receive compensation, personal damages or get off work** – It is not a medical diagnosis, but can lead to a large economic burden on health care systems
154
Give some other types of delusional disorders
Erotomanic - believe another person (often famous/important) is in love with them, may attempt to contact/stalking behaviour Grandiose - overinflated sense self worth, power, identity, believe have talent/made important discovery Jealous - spouse/sexual partner unfaithful without any concrete evidence Persecutory - believe someone/something is mistreating/spying on/attempting to harm them, may repeatedly contact legal authorities Somatic - physical issue/medical problem e.g. parasite, bad odour
155
Define paranoid personality disorder and list some of its features (A)
unwarranted tendency to interpret the actions of others as demeaning or threatening Thinks the world is – a conspiracy Think people are – devious Acts as if – always on guard, suspicious
156
Define schizoid personality disorder and list some of its features (A)
pervasive pattern of indifference to social relationships and a restricted range of emotional experience and expression ***aloof*** Thinks the world is – uncaring Thinks people are – pointless, replaceable Thinks they are the only person they can depend on Commonest behaviour – withdrawal Least likely to be – emotionally available and close Schizoi**D** - = **Distant**
157
deifne schizotypal personality disorder and list some of its features (A)
pervasive pattern of deficits in interpersonal relatedness and peculiarities of ideation, experience, appearance and behaviour Strong desire to have relationships, unable to maintain them - poor at gauging others perception of them Schizo**T**ypical - magical **t**hinking
158
What are some similarities and differences between cluster A personality disorder and schizophrenia?
Similarities - can have paranoia, and will experience the negative symptoms - of flat affect, and blunted emotions *indeed, maybe a genetic link between the two?* ask about FH of one in relatives when taking a history for the other* Differences - Paranoia is more intense in schizophrenia, and in schizophrenia, you have delusions, as well as positive symptoms like hallucinations and racing thoughts
159
What are the personality disorders grouped together in Cluster B?
**Bad** borderline (emotioanlly unstable) antisocial, histrionic narcissist, BAHN
160
Define borderline personality disorder and list some of its features
Aka emotionally unstable - intense joy <--> rage Most common type Definition = pervasive pattern of instability of mood, interpersonal relationships and self-image * Self-damaging impulsivity (spending, sex, substance abuse, reckless driving, binge-eating) Thinks people are – untrustworthy Ashamed of themselves Commonest behaviour – self-harm Terrified of abandonment - might do extreme things to keep from leaving Least likely to be – able to show self-compassion Charlotte from Strike?
161
Define antisocial personality disorder and list some of its features
* Gross irresponsibility * Incapacity for maintaining relationships * Irritability - Disregard for moral values, - manipulative - Often charming * Low threshold for frustration and aggression * Incapacity for experiencing guilt * Deceitfulness * Disregard for personal safety *Have to be over 18 to get the diagnosis of this, with a history of conduct disorder* *Overrepresented in the prison population*
162
Define histrionic personality disorder and list some of its features
Definition = pervasive pattern of excessive emotionality and attention seeking Thinks the world is – their audience Thinks people are – in competition for attention Thinks they are vivacious (attractively lively and animated) Commonest behaviour – exhibitionism Least likely to be – able to listen to others Few meaningful relationships, v superficial
163
Define narcissistic personality disorder and list some of its features
pervasive pattern of grandiosity, lack of empathy and hypersensitivity to the evaluation of others Thinks the world is – a competition Thinks people are – inferior Thinks they are – special Commonest behaviour – competitiveness Least likely to be – humble
164
What personality disorders can be seen in Cluster C?
Obsessive-Compulsive Personality Disorder (ICD), or Anankastic (DSM) Anxious (ICD) or Avoidant (DSM) Dependant PD OAD
165
Name some other conditions that are thought to have a genetic link with personality disorders seen in Cluster B?
Depression Bipolar Substance abuse disorder
166
Define anankastic/obsessive compulsive personality disorder and list some of its features How can it be distinguished from OCD (obsessive compulsive disorder)
pervasive pattern of perfectionism and inflexibility * Excessive doubt, caution, rigidity and stubbornness * Preoccupation with details, rules, lists, order * Perfectionism interfering with task completion
167
Outline some of the management optiosn seen in helping those with personality disorders
Structure, consistency and clear boundaries (i.e. agreement of behaviour that is acceptable and unacceptable) help with housing and other social matters Drugs are sometimes used to treat specific PD traits, e.g. mood stabilisers for impulsivity (not generally recommended because of lack of evidence). Continuity of care very important – changes in doctors etc. may invoke strong emotional reactions
168
What is some additional treatment you can give for treatment for an boarderline personality disorder?
Medications – mood stabilisers, sedatives during borderline PD crises Mood stabilising medication Topiramate Lithium Valproate Lamotrigine Adapted CBT for borderline PD
169
Outline the method of action for SSRIs
SSRIs inhibit the reuptake of serotonin. As a result, the serotonin stays in the synaptic gap longer than it normally would, and may repeatedly stimulate the receptors of the recipient cell
170
What are some side effects of SSRIs?
Nausea, indigestion Worsening of sexual dysfunction Weight gain Suicidal thoughts in younger people Serotonin syndrome
171
What are some drugs that SSRIs interact with, that you would need to provide w PPI cover?
NSAIDs, Aspirin and Heparin - give a PPI cover NB - fluoxetine and paroextine have higher risk of interaction, as particulary good at inhibiting Liver enzymes
172
What are some drugs that can precipitate serotonin syndrome in people with SSRIs?
Linezolid Monoamine oxidase inhibitors (MAOIs) Lithium MDMA Tramadol St. John's wort Tricyclic antidepressants (TCAs) Serotonin-norepinephrine reuptake inhibitors (SNRIs) NB - fluoxetine and paroextine have a higher risk of interaction, as particularly good at inhibiting Liver enzymes
173
What is serotonin syndrome?
Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. Diagnosis is based on a person's symptoms and history of medication use. Other conditions that can produce similar symptoms such as neuroleptic malignant syndrome, malignant hyperthermia, anticholinergic toxicity, heat stroke, and meningitis should be ruled out
174
What are some symptoms of serotonin syndrome
The symptoms are often present as a clinical triad of abnormalities: Cognitive effects: headache, agitation, mental confusion, hallucinations, coma Autonomic effects: shivering, sweating, hyperthermia, vasoconstriction, tachycardia, nausea, diarrhea. Neuromuscular hyperactivity : myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor.
175
Outline examples of SNRIs
Venlafaxine Duloxetine
176
Outline some different examples of SSRIs
Sertraline Citalopram Fluoxetine
177
What is the MOA of SNRIs?
Leads increased concentration of norepinephrine in the synaptic cleft. - Inhibits 5HT reuptake pumps and NAd transporter At low doses, they act like an SSRI - noradrenaline changes don’t occur much at low doses
178
What are some side effects of SNRIs?
aise BP, contraindicated in heart disease Similar to SSRIs Similar to SSRI = Sweating Dose-dependant hypertension
179
Outline some examples of tricyclic antidepressants
Amitriptyline Imipramine Clomipramine Dosulepin Higher Dose **depression, lower dose - used for pain**
180
Give some roles of Serotonin in the brain
CNS Modulates thermoregulation, behaviour and attention PNS Regulates GI motility, vasoconstriction, bronchoconstriction, uterine contraction Other Promotes platelet aggregation (combined use with antiplatelet can increase bleeding risk
181
Outlline the MOA of tricyclic antidepressants
Action on the presynaptic neurone - inhibit the uptake of monoamines at the presynaptic membrane (bind to ATPase monoamine pump) Increase serotonin, noradrenaline Decrease acetylcholine, histamine, sodium and calcium
182
What are some side effects of tricyclic antidepressants?
Dangerous in overdose due to It affecting sodium and calcium - very cardiotoxic CHECK ECG IF THE PATIENT IS ON THESE Look for - **Wide QRS - more than 3 small squares** - **Sinus tachycardia** Anticholinergic side effects: Blurred vision - pupil dilation Urinary retention Dry mouth Constipation Confusion agitation
183
When would you consider using Monoamine Oxidase inhibitors?
MAOIs are seldom used, and then only in treatment - resistant depression or atypical depression **old fashioned** (depression with increased sleep, increased appetite, and phobic anxiety). Basically, in atypical depression
184
How do monoamine oxidase inhibitors work?
MAOIs inactivate monoamine oxidase enzymes that oxidise the monoamine neurotransmitters, such as **dopamine, noradrenaline, serotonin (5 - HT), and tyramine.** - more of them in the CNS
185
What are some side effects of Monoamine oxidase inhibitors? Give some examples of them
Can cause v. v. high BP if taken with tyramine (aged cheese, cured meats, broad beans). **Tyramine reaction crisis** can lead to SAH anticholinergic side - effects, weight gain, insomnia, postural hypotension, tremor, paraesthesia of the limbs, and peripheral oedema eg Selegiline, Phenelzine
186
Define Phenomenology - how does it shape psychiatric practise?
the direct investigation and description of phenomena as consciously experienced by an individual, namely a patient Pysch, emphasises that psychiatric symptoms should be diagnosed according to their form rather than according to their content. This means, for example, that a delusion is a delusion not because it is deemed implausible by a person in a position of authority, such as a doctor, but because it is ‘ an unshakeable belief held in the face of evidence to the contrary, and that cannot be explained by culture orreligion ’ <3 xxxx
187
When would you perscribe lithium?
acute manic episodes and in the long-term prophylaxis of Bipolar affective disorder Lithium should only be started if there is a clear inten ion to continue it for at least three years, as poor complince and intermittent treatment may lead to rebound mania. The starting dose of lithium should be cautious
188
Give some side effects of atypical antidepressants, like Mirtazapine
Drowsiness Weight gain
189
What are some side effects of lithium at lower dose?
Side effects - at lower doses 0.4-1 mmol/L * Nausea * Fine tremor * Weight gain * Oedema * Polydipsia and polyuria * Hypothyroidism
190
What are some side effects of lithium toxicity? Above 1.0 mmol/L
Above 1.0 mmol/L Signs of toxicity * Vomiting * Diarrhoea * Coarse tremor * Slurred speech * Ataxia * Drowsiness and confusion Lithium **is Teratrogenic!!**
191
What pyschiatric disorder could you use sodium valporate and carbamazepine, and lamotrigeine for?
Bipolar, prophylactically They are **Teratrogenic!!**
192
What are some side effects of Sodium valporatte and lamotrigine ?
Lamotrigine Skin reactions (including Stevens– Johnson syndrome) aseptic meningitis drowsiness diplopia leucopenia insomnia Sodium valpoarate Nausea Gastric itrartaion diarrhoea Weight gain They are **Teratrogenic!!**
193
Name 3 broad kinds of psychological therapies
1 Supportive therapy *Explorative pyschotherapies=* 2 Cognitive and Behavioural therapies 3 Psychodynamic therapies
194
Outline what is seen in supportive therapy - for what may it be used?
Explanation and reassurance establishing rapport, facilitating emotional expression, reection, reassurance * Non-directive problem-solving, e.g. for adjustment disorders, stress, bereavement * Mild depression or anxiety Counselling is similar to supportive therapy in that it involves explanation, reassurance, and support.
195
Outline what is seen in CBT
This is a therapy with works on the interplay between thoughts, emotions and behaviours. Its aim it to tackle both negative the cognitive thinking and behaviour in mental illness. a) Cognitive –> Aim is to help people identify and challenge automatic negative thoughts and abnormal beliefs b) Behaviour –> This is based on learning theory of operant condition (positive and negative reinforcement) – If people have habitual wrong behaviours (e.g. avoidance in anxiety) it teaches people relaxation techniques and gradual exposure with positive reinforcement to change their behaviour.
196
For what things can CBT be used to treat?
CBT is used to treat depression, anxiety, eating disorders and some personality disorders. It can also be used to treat psychosis
197
Outline what is seen in psychodynamic/pyshcoanalyitc therapies
psychoanalysis stems from the work of Sigmund Freud. - views human behaviour as determined by unconscious forces derived from primitive emotional needs. Therapy aims to resolve longstanding underlying conflicts and unconscious defence mechanisms (e.g. denial, repression). Helping the person to become more aware of the unconscious processes which are giving rise to symptoms or to difficult repeating patterns Helping the person construct a narrative of their life and give meaning to symptoms
198
What is the general procedure seen in Psychodynamic therapies? e. g. Psychoanalysis + Psychodynamic Psychotherapy
– The patient explores their subconscious by using free association (says whatever is on their mind) – The therapist interprets these statements to **link the patient’s past experience with their current life** and their relationship with the therapist. This uses 2 skills: – Transference –> when the **patient re-experiences strong emotions from early relationships** with the therapist – Counter-transference –> When the therapist experiences strong emotions towards the patient **The relationship heals!!!!!!**
199
Outline what is seen in Cognitive Analytic Therapy (CAT) For what can it be used?
Short time, cheaper pyschological treatment – It looks at the ways an individual think and feels and the events and relationships underlying experiences. – They key of this therapy is reflection after – therapist writes a goodbye letter and asks patient to respond - **gets patients to find new nad better ways of coping with established problems** Used in 'Personality Disorder’, Eating disorders
200
What is seen in Dialetcai ldehvaiour therapy? When may it be used?
similar to CBT and also provides group skills training to equip the individual with alternative coping strategies Skills such as mindfulness (bringing one’s attention back to thepresent moment), which is **derived from Buddhist meditation.** Used for those with Boarderline personality disorders, eating disorders
201
Outline what is seen in Eye movement desensitization and reprocessing
– Patients then recall the disturbing events and the emotion they felt at the time (e.g. sexual abuse and feeling powerless – They then work together to create a positive belief about the event (“I am stronger now and so not powerless”) – The therapist then activates both sides of your brain using Dual Activation Stimulation (DAS) by making they do eye movements usually involves the therapist directing the patients’ lateral eye movements by asking them to look first one way then the other (saccadic eye movements) – This allows the brain to reprocess the upsetting memories by removing the old emotion and replacing it with the more positive, empowering emotion – This means the memory is no longer experienced as a traumatic.
202
What is seen in interpersonal psychotherapy, and for what may it be used for?
IPT is a talking treatment that helps people with depression identify and address problems in their relationships with family, partners and friends. The idea is that poor relationships with people in your life can leave you feeling depressed, it gets the patient to view their emotions in terms of their interpersonal network e.g. a close member may have died (causing grief) The rest of the session then involves work on how to cope and change their views of these events and transform their relationship into a positive one used for moderate and severe depression IPT is usually offered for 16 to 20 sessions.
203
What is ECT? For what can it be used for?
Electroconvulsive Therapy - uses electrodes to induce a modified cerebral seizure Severe depression Prolonged or severe episode of mania that has not responded to treatment Cataonia ECT should be used to induce fast and short-term improvement of severe symptoms after all other treatment options have failed, or when the situation is thought to be life-threatening (because of high risk of suicide or not eating and drinking).
204
How is ECT thought to work?
This is a treatment option which uses electrodes to induce a modified cerebral seizure in the brain – This leads to massive amounts of neurotransmitter release, hormone secretion and a transient increase in blood brain barrier permeability. – It is used to induce fast improvement after all other treatment options have failed
205
When does English Mental Health Act permit ECT to be given?
Patient gives informed consent (before every treatment) The patient lacks capacity, and it does not conflict with advance decision AND It’s an emergency, and the independent consultant has not yet assessed (Section 62 of Mental Health Act) OR An Independent Consultant (appointed by Mental Health Act Commission) agrees to it **IF A PATIENT HAS CAPACITY AND REFUSES, IT CANNOT BE GIVEN**
206
Outline the procedure of ECT
Procedure: – Patient is nil-by-mouth for 4 hours before intervention – Patient is given short-acting anaesthetic + muscle relaxant drug – Preoxygenation is given to increase SpO2 – A shock is delivered to the scalp either bilaterally or unilaterally – This evokes a 20-60s seizure within the brain
207
What are some contraindications for ECT
– Raised intracranial pressure (absolute) – Stroke and MI (relative contraindication
208
What are some side effects of ECT?
Patients have reported that ECT causes cognitive impairment. Therefore cognitive function should be assessed prior to, during and after a course of treatment. Assessment should include: * orientation and time to reorientation after each treatment, * new learning, * retrograde amnesia, * subjective memory impairment. * dysrhythmias due to vagal stimulation, postictal headache, * confusion, * retrograde and anterograde amnesia with difficulties in registration and recall that may persist for several weeks
209
What is the management of serotonin syndrome?
IV fluids, cooling measures Benzodiazepines Stop offending agent If Sx persist after stimulus removed, consider cyproheptadine (serotonin antagonist)
210
What is Neuroleptic malignant syndrome?
Psychiatric emergency caused by excess of neuroleptic medication (aka both typical and atypical antipsychotics) or acute withdrawal from Parkinson's medication Cocaine and ectasy can also cause it
211
Why does Neuroleptic malignant syndrome happen? What are some symptoms of it?
NMS results from as dopaminergic hypothalamic spinal tracts are blocked, so they can't tonically inhibit preganglionic sympathetic neurons as usual Occurs over hrs-days (within 10d) - gradual Hyperpyrexia Hyporeflexia Fluctuating consciousness Diffuse rigidity Raised CK - Rhabdomyolysis can occur
212
What is the management of Neuroleptic malignant syndrome?
The mainstay of treatment involves stopping the drug and supportive measures such as oxygen, IV fluids, and cooling blankets Drugs - **dantrolene and lorazepam** may also be used to decrease muscle rigidity.
213
What are some symptoms of opiate overdose
Acute presentation = drowsiness Respiratory depression -> resp acidosis CO2 retention) Hypotension Tachycardia Pinpoint pupils Chronic = constipation
214
What is the management of an opiate overdose?
ABCDE approach * Methadone (opioid agonist) or buprenorphine (opioid partial agonist) are first line; they are less euphoriant and have a relatively long half-life than opioids of abuse. * Lofexidine is sometimes used for short detoxification treatments or where abuse is mild or uncertain Naltrexone (opioid antagonist) blocks the euphoric effects and is occasionally used to help prevent relapse.
215
What are some signs of opioid withdrawal?
Clinical features of withdrawals are mediated by noradrenaline overactivity: * Dilated pupil * Tachycardia + hypertension * Insomnia, restlessness, anxiety, irritability, tremor * Abdo pain, nausea, vomiting, diarrhoea * Watering eyes * Muscle aches Treatment **Lofexidine**
216
Give some risk factors for a substance abuse disorder
Addiction liability - depends on: How substance taken: orally, injection, inhaling Rate substance crosses blood brain barrier and triggers reward pathway in brain Time takes to feel effect of substance Substance ability to induce tolerance ± withdrawal symptoms Male Aged ~ 18-25 Mental health conditions: ADHD, bipolar, depression, GAD, panic disorder, PTSD Adverse childhood experiences: childhood abuse/neglect, witnessing domestic violence, family members with SUD
217
How many g and ml is one unit of alchohol
One unit of alcohol is equivalent to 10ml or 8g of pure alcohol
218
Outline some of the physiological effects that alcholol has on the body
* Alcohol increases GABA function (GABA-A receptor activation) * GABA is the main inhibitory neurotransmitter in the brain - calming effect * Alcohol reduces glutamate function - inhibitory action at NMDA glutamate receptors ○ Glutamate is the major excitory neurotransmitter that is involved in brain processing such as learning and memory ○ Effects on glutamate lead to amnesia and sedation
219
What are some signs of alchohol dependance?
CANT STOP C - compulsion to drink A - aware of harms but persists N - neglect of other activities T - tolerance to alcohol S - stopping causes withdrawal T - time preoccupied with alcohol O - out of control use P - persistent, futile wish to cut down Withdrawal Tremors Anxiety Nausea, vomiting Headache Tachycardia Irritability, aggression Delirium
220
In both ICD - 10 and DSM - IV the first step in diagnosis is to specify the substance or class of substance - what kind of substances are commonly involved in substance abuse?
ICD - 10 F10 Alcohol F11 Opioids F12 Cannabinoids F13 Sedatives or hypnotics F14 Cocaine F15 Other stimulants, including caffeine F16 Hallucinogens F17 Tobacco F18 Volatile solvents F19 Multiple drug use and other
221
The second step in diagnosis is to specify the type of disorder involved, according to the ICD 10 - what types of substance abuse disorders are there?
ICD - 10 .0 Acute intoxication .1 Harmful use .2 Dependence syndrome .3 Withdrawal state .4 Withdrawal state with delirium .5 Psychotic disorder .6 Amnesic syndrome .7 Residual and late-onset psychotic disorder .8 Other mental and behavioural disorders
222
What are some investigations/questionaires to screen for alcohol dependency?
CAGE questionnaire screening C - do you ever think about cutting down A - do you get annoyed when others comment on drinking habit G - ever feel guilty about drinking E - ever drink in morning (eye-opener) AUDIT questionnaire Developed by WHO Multiple choice for harmful alcohol use screen
223
What are some blood tests results you would see in an alcoholic?
Bloods Raised MCV Raised ALT and AST (AST:ALT ratio above 1.5 suggests ALD) Raised GGT Raised ALP later in disease Raised bilirubin in cirrhosis Low albumin (reduced synthetic function of liver, reduced clotting factor production) Deranged U&Es in hepatorenal syndrome
224
What is the management for someone who is alcohol dependant?
Management – Patients are often referred to an alcohol dependence programme to help them quit. – They can use a mixture of behavioural interventions (e.g. CBT) and pharmacological treatment – Disulfiram –> this inhibits acetaldehyde dehydrogenase, so people feel hungover as soon as they drink alcohol (avoid in ischaemic heart disease) – Acamprosate –> this is a weak NMDA antagonist which is used to reduce alcohol craving
225
Outline the pathophysiology behind delirium tremens
Alcohol boosts GABA, which inhibits the brain and dampens excitatory glutamate receptors. Over time, the brain adapts, becoming more sensitive to excitatory signals. When alcohol stops, the brain becomes overactive, causing symptoms like confusion and agitation.
226
what are some symptoms of delerium tremens? What is the management?
Symptoms – Together they are called delirium tremens – Early on –> increased anxiety, with sweating and agitation – After 24 hours –> Seizures with visual hallucinations – From 48-72 hours –> Course tremors, agitation, delusions and severe visual hallucinations Management – 1st line is benzodiazepine chlordiazepoxide
227
How can we gauge the severity of alcohol withdrawal?
The CIWA-Ar is used to guide the pharmacological management of alcohol withdrawal. Clinicians add up scores for all ten criteria. The total CIWA score can be used to assess the presence and severity of alcohol withdrawal: Absent or minimal withdrawal: score 0-9 Moderate withdrawal: score 10-19 Severe withdrawal: score > 20 The total CIWA score influences the frequency at which further observations are made: Initial score is ≥ 8: repeat hourly for 8 hours. Then if stable 2-hourly for 8 hours. Then if stable 4-hourly. Initial score < 8: assess 48-hourly for 72 hours and if score < 8 for 72 hours, discontinue assessment. The total CIWA score guides clinicians with regards to the need for pharmacological management of alcohol withdrawal: Symptom-triggered regimen (not prescribed regular withdrawal medication): give PRN medication when CIWA score is ≥ 8 Fixed-dose reducing regime with PRN medication (prescribed regular withdrawal medication): give additional PRN medication if CIWA score is ≥ 15
228
Define Wernicke's Encephalopathy
is a neurological emergency resulting from thiamine deficiency with varied neurocognitive manifestations.
229
What is Korsakoff's Syndrome? How is it related to Wernickes?
Hypothalamic damage & cerebral atrophy due to thiamine (vitamin B1) deficiency (eg in alcoholics). Wernicke's encephalopathy is the acute, reversible stage of the syndrome, and if left untreated it can later lead to Korsakoff syndrome, which is chronic and irreversible.
230
How can chronic alcoholism lead to a thiamine deficiency?
It **block the phosphorylation of thiamine**, stopping it from being converted into its active form Ethanol **reduces gene expression of Thiamine transporter**, so can stop it getting absorbed in the duodenum. Alcoholic tend to have a poor diet, relying on alcohol for calories so will not get enough Thiamine (b1) anyway
231
How can a lack of thiamine (vit B1) affect the brain?
- Thiamine deficiency impairs glucose metabolism and this leads to a decrease in cellular energy. - The brain is particularly vulnerable to impaired glucose metabolism since it utilises so much energy.
232
What is the classical triad seen in Wernicke's encephalopathy?
1 confusion 2 ataxia (wide-based gait; fig 2) 3 **ophthalmoplegia** (nystagmus, lateral rectus or conjugate gaze palsies).
233
What does Wernicke - Korsakoff syndrome predominantly target? What symptoms does this cause?
- Mainly targets the limbic system, causing severe memory impairment: - **Anterograde amnesia:** inability to create new memories - **Retrograde amnesia:** inability to recall previous memories. - **Confabulation:** creating stories to fill in the gaps in their memory which they believe to be true. - **Behavioural changes**
234
What investigations would you do in suspected Wernicke's encephalopathy?
- Diagnosis is typically made **based on clinical presentation** - **Bloods including LFTs**: measure thiamine levels, measure blood alcohol levels, liver function may be deranged in alcoholism - **Red cell transketolase test:** rarely done, thiamine is a co-enzyme to transketolases so transketolase activity will be low - **MRI/CT:** can confirm diagnosis by showing degeneration of the mammillary bodies Lumbar puncture to rule out other causes of the symptoms of wernickes
235
What is the management for Wernicke's encephalopathy?
Urgent replacement to prevent irreversible Korsakoff’s syndrome (p718). Give thiamine (Pabrinex®) Oral supplementation (100mg OD) should continue until no longer ‘at risk’, *give other B vitamins as well* Correct Magnesium deficiency as well If there is coexisting hypoglycaemia, correct it
236
Why do you need to give Thiamine before you give glucose in a patient with Wernicke's?
it’s important to normalise the thiamine levels first, because without thiamine pyrophosphate, **most of the glucose will become lactic acid and that can lead to metabolic acidosis.** (often the case in this group of patients), make sure **thiamine is given before glucose**, as Wernicke’s can be caused by glucose administration to a thiamine-deficient patient - ***NOT GIVING THIAMINE AS YOU JUST THINK ITS HYPOGLYCAEMIA IS A COMMON MISTAKE DOCTORS MAKE***
237
What is the mangaement of alchohol withdrawal?
Pharmacological management of alcohol withdrawal and detoxification * Chlordiazepoxide - benzodiazepine commonly used in the UK (long acting) * Diazepam (long acting) * Lorazepam (short acting) - can be considered when there is liver injury Oxazepam (short acting)
238
How do cocaine and ampethamines work?
These drugs block the reuptake of dopamine and noradrenaline (and 5-HT) increasing transmission at synapses
239
What are some signs of a cocaine/amphetmanie overdose?
Main effect – Increased energy and concentration, euphoria and hyperactivity Side effects: – Cardiovascular –> Increased pulse, blood pressure, hyperthermia, can lead to aortic dissection – Heart –> QRS widening and QT prolongation – GI –> Reduced appetite and ischaemic colitis – Psychological –> Insomnia, agitation and hallucinations e.g. formication (sensation of ants under the skin) – If you take a prolonged large dose, the euphoria can turn to depression and anxiety – Can get psychosis –> delusions, visual and auditory hallucinations
240
What is the management of a cocaine overdose?
– IV benzodiazepines + treat complications (heart attack, aortic dissections) + antipsychotics
241
What are the 5 key principles you must consider when assessing mental capacity
i) A person is **assumed to have capacity** is assumed until it is established that the person lacks it ii) A person should not be treated as unable to decide **unless all practicable steps to help them have failed** iii) A person should **not** be treated as unable to decide **just because it is unwise** iv) Decisions made on **behalf of an incapable person must be in their best interests** v) Regard should be taken to **find the solution which is least restrictive of the person’s rights and freedom of action**
242
Under the MCA, what are the 3 reasons why you may provide treatment for someone who does not have capacity?
– If a valid advanced decision to refuse treatment exists – If a valid Lasting Power of Attorney for Health and Welfare exists – If neither exists, the person providing treatment should act in the patient’s best interests.
243
In order to section someone *(forcibly admit someone to hospital/secure setting)*, for **assessment** what is grounds/personal is required and for how long? What part of the MHA?
Under section 2 of the mental health act Need 2 Drs: one section 12 approved, one ideally previous contact w/ pt, and then approval from approved mental health professional (AMHP) to confirm the section. Patient suffering from mental disorder to degree that warrants detention in hospital for assessment Pt should be detained for own health/safety or the protection of others **Lasts 28 days, cannot be renewed**
244
In order to section someone *(forcibly admit someone to hospital/secure setting)*, for **treatment** what is grounds/personal is required and for how long? What part of the MHA?
Under section 3 of the mental health act Again, Need 2 Drs: one section 12 approved, one ideally previous contact w/ pt, and then approval from approved mental health professional (AMHP) to confirm the section. Patient suffering from mental disorder to degree that warrants detention in hospital for treatment. Pt should be detained for own health/safety or the protection of others The treatment needed cannot be effectively provided unless the patient is detained. Appropriate medical treatment is available to them. lasts 6 months, can be renewed
245
What is outlined in section 4 of the MHA?
Patient suffering from mental disorder to degree that warrants detention in hospital for assessment Pt detained for own safety/safety of others Not enough time for 2nd Dr to attend i.e. due to risk 1 Dr (does not need to be section 12 approved) Can only last 72 hours
246
What is outline in section 5 of the mental health act, both in 5(2) and 5(4)
For pt already admitted (to psychiatric/general hospital) but wanting to leave section 5(4) says Nurses can detain patients in hospital (this is their holding power until a Dr can attend,) for **6 hours** Section 5(2) says Doctors (this is their holding power until section 2/3 can be put in place) NB - has to be Dr on a specific ward, cannot be done in A&E, for **72 hours**
247
What is outlined in section 135 of the mental health out
135 - allows police to enter house and mreove a patient to a place of safety 136 allows police to take someone to a place of safety for an assessment Both can be done by a police, but the should try and confirm this with a doctor or nurse Both for a duration of 72 hours
248
If a patient has been detained under section 2,3,35,36 or 37, is consent required for treatment
Consent to Treatment As a general rule, once a patient is detained under S2, 3, 35, 36 or 37 of the MHA, consent is not required for the administration of psychiatric treatment. – The justification for treatment is provided by S63 which states that: “The consent of a patient shall not be required for any medical treatment given to him for the mental disorder from which he is suffering” Treatments are Covered by S63 All medical treatment for the mental disorder, including: Treatments for the disorder itself (e.g. antipsychotics for schizophrenia) Treatments for conditions causing the disorder (e.g. hypothyroidism causing depression) Treatments for the physical consequences of the disorder (e.g. NG in anorexia) Safe holds and physical control and restraint (when necessary)
249
Define what self harm is - what are some reasons for it?
Intentional non-fatal self-inflicted harm * a desire to interrupt a sequence of events seen as inevitable and undesirable * a need for attention * an attempt to communicate/express themselves * a true wish to die Used to express something hard to put into words, change emotional pain into physical pain, have a sense of being in control, punish themselves for feelings/experiences…
250
What are some risk factors for self harm
Unlike completed suicide, DSH is more frequent in women, the under-35s, lower socia l classes and the single or divorced. * Like suicide, DSH is associated with psychiatric illness, particularly depression and personality disorder
251
What are some clinical signs of self harm?
Cuts/scratches on arms/legs Picking at skin Burns Bruising Weight loss/weight gain Hair loss (pulling at hair)
252
When assessing self harm/suicide attempt, what are the 3 domains you should split factors into?
Before During After
253
Suicide and self-harm risk assessment - what things should you try to find out about BEFORE they attempted suicide/self-harm?
Precipitants - specific event/build up? Planned/impulsive? Precautions taken against discovery? (left the house, turned off phone etc) Alcohol/recreational drugs at time of event? - suggests more impulsive
254
Suicide and self-harm risk assessment - what things should you try to find out about DURING they attempted suicide/self-harm?
Method (if drugs - what did they take, how much) Was pt alone Where was it - more remote = higher risk What went through mind at the time Did they think their self-harm would end their life? What did they do straight after the self-harm?
255
Suicide and self-harm risk assessment - what things should you try to find out about AFTER they attempted suicide/self-harm?
Did pt call anyone? Go to A&E? Who were they found by How they felt when help arrived Current mood Still feel suicidal? - would they attempt again
256
What are some clinical signs of suicidal behaviour?
Warning signs: * Obsessive thinking about death * Feelings of hopelessness, worthlessness, helplessness * Behaviours suggestive of absolute death wish: ○ Put financial affairs in order ○ Visiting people to say goodbye in community, awareness of pts who: Frequently, repeatedly attend Disengaged w/ services Prescribed several antidepressants Heightened concern from family members
257
What are some risk factors for suicide?
SAD PERSONS Sex (male) Age <19 or >45 Depression Previous suicide attempt Excess alcohol or substance use Rational thinking loss Separated or single Organised plan No social support Sickness
258
What are some management options for self harm?
A good first step is to agree with patients what their problems are and what immediate interventions are both feasible and acceptable to them. * Ensure that they know who they can turn to if suicidal intent returns (e.g. A & E). * Crisis Resolution Team referral may be necessary if suicidal ideation is present. * Think about reducing access to means of suicide if possible – for example, by encouraging patients to dispose of unneeded tablets from the home, and by prescribing antidepressants of lower lethality (e.g. SSRIs rather than tricyclics) and in small batches. * Consider psychological therapy and encouraging engagement in self-help and community social and support organisations.
259
what are some principles around suicide prevention?
* Detect and treat psychiatric disorders. * Be alert to risk and respond appropriately to it. * Prescribe safely * Give urgent care at appropriate level of patients with suicide intent – refer to Crisis Resolution and Home Treatment Teams. - Can also admit for hospitalization (consider detention under the Mental Health Act) if patients considered unsafe outside hospital even with intensive support. *Provide careful management of deliberate self-harm (DSH) * Act at the population level, tackling unemployment and reducing access to methods of self-harm.