Psychiatry Flashcards
give 2 examples of typical antipsychotics
haloperidol
chlorpromazine
give 4 examples of atypical antipsychotics
clozapine
risperidone
olanzapine
aripiprazole
MOA of typical antipsychotics
D2 receptor antagonists (block dopamine)
MOA of atypical antipsychotics
act on dopamine and HT
major side effect differences between typical and atypical antipsychotics
typical: extrapyramidal and increase prolactin levels
atypical: metabolic and weight gain
which antipsychotic causes life threatening agranulocytosis and neutropenia
what do you monitor
clozapine
FBC for leukocytes
give 4 examples of extrapyramidal side effects in antipsychotics
parkinsonism (bilateral resting tremor)
acute dystonia (muscle contraction causing torcollis)
akathisia (restlessness)
tardive dyskinesia (involuntary movements - chewing, pouting, blinking)
which antipsychotic has the least effects on prolactin
aripiprazole
medication to manage torcollis
procyclidine
medication to manage tardive dyskinesia
tetrabenazine
name some other side effects of antipsychotics
stroke/VTE
sedation
seizures
increased QT
sedation
galactorrhoea
antimuscarinic
neuroleptic malignant syndrome
reduced glucose tolerance
weight gain
4 antimuscarinic side effects
dry mouth
blurred vision
constipation
urinary incontinence
which antipsychotic increased the QT interval the most
haloperidol
pyrexia and muscle stiffness on antipsychotic
neuroleptic malignant syndrome
main side effect and management of SSRI
GI disturbance
give PPI
which side effect does citalopram cause
prolonged QT interval
torsades de pointes
which medication do SSRIs interact with to cause serotonin syndrome
MAOis
dizziness, shock and anxiety on SSRI
discontinuation
effect of using SSRIs during the third trimester
persistent pulmonary hypertension of the newborn