Psych Flashcards
Tx most effective against Negative sx
Atypical antipsychotics
Psychotic Disorders (5)
Delusional disorder Brief Psychotic disorder Schizophreniform disorder Schizophrenia Schizoaffective disorder
Delusional disorder
Poor insight
Psycho-social fx NOT markedly impaired
Non-bizarre delusions, plausible but false
Delusional disorder DSM5
Non bizarre delusions fr >1 month
Fx not impaired
Behavior not odd
Mood episodes (if present) are brief relative to delusion
Delusional disorder subtypes
Erotomanic- another person is in love with the pt
Grandiose- big head
Jealous
Persecutory- thinks someone is out to get them
Somatic- physical defect or medical condition
Mixed
Unspecified
Brief Psychotic Disorder
Sudden onset of at least 1 positive sx
lasting 1 day- 1 month, then return to normal
Emotional, labile, confused
Onset late 20s-early 30s
(may be w marked stress or post partum)
Brief Psychotic Disorder- worry about
High risk of Suicide
Brief Psychotic Disorder DSM5
Presence of 1 or more: delusions, hallucinations, disorg speech, grossly disorg/catatonic behavior
lasting 1 day-1 month, with eventual FULL RETURN TO NORMAL fx
Schizenophreniform Disorder
Essential features same as Schizophrenia, but
SHORTER DURATION
1-6 months
1/3 recover
2/3 progress to Schizophrenia
Schizophreniform disorder DSM5
Presence of TWO or more: Delusions, hallucinations, disorg speech, grossly disorg/catatonic behavior
lasting 1 month-6 months
Schizophrenia
Heritability 70-90%
1st deg relative risk is 10x that of other population
Males have earlier age of onset 18-25 YO
females: 25-35 YO
Schizophrenia
Neg sx often appear first
Decreased life expectancy- Men 15 years, women 12 years earlier
d/t ischemic heart dz, and CA
Schizophrenia DSM5
at least 1 month of 2+ of the following: delusions, hallucinations, disorg speech, disorg/catatonic behavior, negative sx
Social/job dysfunction
lasting 6 MONTHS
Prognosis with Schizophrenia is BETTER if:
female, later onset
acute onset w precip factor
brief duration, early intervention, tx compliance
positive sx
mood disturbance, family hx of mood disorder
high SES, married, good support system
Good pre-morbid functioning
Schizoaffective disorder
Schizophrenia
PLUS
A mood disorder
Schizoaffective disorder subtypes
Bipolar or Depressed
Delusions/hallucinations 2 wks and normal mood
more common in women (esp depressed)
Schizoaffective prognosis is
better than Schizoaphrenia
Schizoaffective Disorder DSM5
Meet criteria for Schizophrenia and ALSO has Major depressive, Manic, or Mixed episode
must have 2+ wks of delusions/hallucinations without prominent mood
mood sx present for sig portion of illness
Tx for Psychotic disorders
Start antipsych at low dose
Avoid use of 2 antipsychotics
When do things start to improve?
Hallucinations over days
Negative sx, delusions, cognitive def take much longer IF they improve
Indications for hospitalization
DTS
DTO
Command hallucinations
Unable to care for self
1st gen, conventional tx
Dopamine blockers (D2 receptor blockade)
used inpatient; IV
Chlorpromazine (Thorazine)
Haloperidol (Haldol)
Atypical Antipsychotics (2nd gen)
used outpatient
Aripiprazole (Abilify) Clozapine (Clozaril) Olanzapine (Zyprexa) Quetiapine (Seroquel) Risperidone (Risperdal)
SE of Clozapine (Clozaril)
Agranulocytosis
regular CBC and WBC monitoring (weekly initially)
SE of Olanzapine (Zyprexa)
Zyprexa DM
Weight gain
SE of Risperidone (Risperdal)
Prolactin, EPS
All Atypical Antipsych have a BLACK BOX WARNING for
Elderly
EPS- Extrapyramidal sx
Acute dystonic rxn Parkinsonism Akathisia Tardive dyskinesia NMS (lead pipe rigid)
Palliative care
relieving pain without dealing with underlying cause
-not trying to treat the medical condition
Palliative care is for those expected to pass away in
the next few years
5 emotional stages of dying
Denial-isolation Anger Bargaining Depression Acceptance
Hospice care
when it goes from Serious illness –> Terminal condition
Hospice
More intense focus on alleviating fear, anxiety, physical sx, emotional/spiritual distress
Life expectancy over the last 40 years has increased from
68—> 78
MDs overestimate life exp by
3x-5x d/t
difficulty imparting bad news
avoid dashing Hope
Seniors list these as top desires when living with chronic illness
Maintain independence
Be free of pain
Not be burden to family
Hospice care, for those with
<6 mo to live
Palliative team- interdiscp
Social worker Psychologist Pharmacist Nurse Clergy Recreation therapist Medical provider
Goal of Care conversations
What is your understanding of your condition?
Goals?
Fears?
What if your health worsens?
What are the critical abilities you can’t imagine living without?
What are you willing to tolerate as far as further tx?
Communication in serious illness with
SPIKES
Set up convo Perception (what pt knows) Invitation to discuss Knowledge (inform pt) Emotional response Strategy, support, summary
Sex
Biological make up
does not change
XX or XY
Gender
What you can change- how you identify
Sexuality
who you are attracted to- M or F
Cisgender
Happy with biological, gender does align
Non binary, Genderqueer, Agender
Done feel M or F
Gender dysphoria
the stress felt when body doesn’t match what you feel
Intersex
born with ambiguous genitalia or sex organs of both sexes
Cross dresser
enjoys wearing the clothing, but may not want to actually change to that gender
Gender Dysphoria DMS5
Marked incongruence for at least 6 MONTHS, and at least TWO of the following:
- marked incongruence
- strong desire to rid ones own
- strong desire for other gender characteristics
- strong desire to be treated as other gender
- strong conviction that one has feelings/reactions of the other gender
- associated w SIGNIFICANT DISTRESS
If someone wants to change genders, they are offered INFORMED CONSENT
PCP perform initial assmt, physical and mental health, Refer to SPECIALIST
make sure pt knows exactly what they are doing before starting meds/ surgery
Behavioral Health Model (aka Standards Model)
Adding extra step
Letter of referral from Psychologist to assist in medical transition
WPATH- The World Professional Association for Transgender Health
Standards of Care Version 7
evolved to better support pt’s autonomy in choosing WHETHER OR NOT TO SEEK PSYCHOLOGISTS CARE FOR MEDICAL TRANSITION
Surgeons decision whether they require
psychologist letter or not
TransMale
F—> Male
Changing into male
may take several mo to become noticeable, and 3-5 years to be complete
PERMANENT changes of TransMale
Pitch of voice Hair-thicker/dark Grow facial hair Balding pattern Increase clitoris size
TEMPORARY changes of TransMale
Menses Weight gain Muscle mass UE strength More physical energy Skin changes Sex drive Mood
Risk of Testosterone therapy
Loss of fertility (but do NOT use as birth control, could still get pregnant) Cholesterol changes High BP --> increased risk of Cardiovascular dz
Risks (summarized) of transforming into Male with testosterone
High: Erythrocytosis (hematocrit >50%) –> clots
Moderate: Liver dysfx, CAD, CVD, HTN, Breast/uterine CA
with Breast/Uterine CA
not d/t Testosterone directly, rather that the pt stops getting the screening exams that they should be as a female
TransFemale PERMANENT changes
Breast growth
Testicles smaller
Infertile as testes produce less sperm
TransFemale TEMPORARY changes
loss muscle mass,strength weight gain skin/acne decrease facial/body hair softer balding reduced sex drive decreased erection strength change in mood/thinking
Risks (summarized) of Estrogen therapy when transforming into Female
Very high risk: CLOT (thromboembolic dz)
Moderate: Mactoprolactin, breast CA, CAD, CVD, Cholelithiasis, Hypertriglyceridemia
Those on Estrogen will also need Androgen blocker (Spironolactone)
RISK/SE
Increased urine production/freq Drop in BP Lightheaded Inc thirst Inc in K+, leading to: -muscle weakness -nerve probs -heart arrhythmias
Forms of testosterone
Test Cypionate or Enthanate (injectable)
Topical gel
Patch
Estrogen comes in
Pills, patches, and injectable
injectable and pills both same cost and very effective
Androgen blockers help with:
shrinking testes
stopping erections
breast growth
Spironolactone
Finasteride
Screening for Transgender Males
every 3 mo during 1st year
then yearly
total T (goal 400-700) H and H Body weight BP Lipids Pap/cervical exam Osteoporosis screen
Screening for Transgender Females
every 3 mo in 1st year
then yearly
Estradiol goal during first year 100-200
Total T is measured
in BOTH
Bone Mineral Density conducted at
60 YO for those who have stopped hormone therapy
Vaginoplasty
building a vagina
using penile tissue or colon graft
complicatoins: urethral stenosis, fistula, hair growth inside vagina
Mammoplasty
building breasts
complications: capsule formation, implant rupture
Mastectomy
removing breasts
“top surgery”
complication: nipple necrosis, skin flap complication, contour irregularities, scarring
Metoidoplasty
creating a penis
pull enlarged clitoris forward to create phallus of penis
no new material- just freeing up the clitoris and bringing urethra forward
Phalloplasty
building a penis from forearm, thigh, or flank area
erectile prosthesis implanted
complication: urethral stenosis, fistula, flap loss, necrosis
Scrotoplasty
building scrotum from labia majora, testicular implants
complications: infection
the 6 neurocog disorders
“PALLES”
Perceptive-motor Attention Learning/memory Language Executive fx Social
Risk factors for Delirium
age >70 poor fx status hearing/visual impairment dehydration sleep dep metabolic derangement infection polypharmacy
Dementia/Major neurocog disorder
significant cognitive decline
interfere w independence in everyday activities
Specify dementia on basis of interference
Mild: diff with housework
Moderate: diff with basic activities
Severe: fully dependent
Mild neurocog disorder
does not interfere with independence
Alzheimers
insidious, gradual onset
usually after 50 YO
higher rates in repeated head trauma or Down syndrome
Familial
Myoclonus and gait disorder: late findings
Frontotemporal degeneration
Either a behavioral or language variant
disinhibition, apathy, loss of sympathy, stereotyped behavior, hyperorality
decline in speech, word finding, naming, grammar, comprehension
Lewy body disease
Fluctuating cognition
Recurrent visual halluciations
Spontaneous features of Parkinsonism
REM sleep disorder
Do NOT give these pts Antipsychotics
Prion disease
Rapid progression
Myoclonus or Ataxia
MAD COW DISEASE
usualy course <6 mo, psych sx, EEG pattern
QUICK DETERIORATION
HIV
forgetfulness, slowness, poor problem solving
Tremor, ataxia common
Huntingon Dz
Autosomal dominant
30s-40s
Choreiform movement
“Boxcar ventricles”
Tx of Dementia management
Cholinesterase Inhibitor
- Donepazil (Aricept)
- Galantamine (Razadyne)
- Rivastigmine (Exelon)
NMDA antagonist
-Memantine (Namenda)
Supplements that may have small benefit with Dementia
Vit E/Selegiline
Anti-oxidants
Anti-inflammatory