friday flashcards

1
Q

alzheimers

A

strong MEMORY impairment

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2
Q

Frontotemporal degeneration

A

Behavioral or Language variant

loss of sympathy, decline in speech

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3
Q

Lewy Body dz

A

Visual Hallucinations
REM sleep disorder

SEVERE sensitivity to Antipsychotics

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4
Q

Dont give Antipsychotics to

A

pts with Lewy Body dz

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5
Q

Vascular

A

dementia brought on by TIA or Stroke

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6
Q

Vascular dementia, will see on MRI

A

White matter hyperintensity

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7
Q

TBI (concussion)

A

LOC, post trauma amnesia, confused, neuro signs

can be acute or repeated trauma

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8
Q

Poorer outcomes w TBI are

A

repeated concussion
>40 YO
poor motor fx
non-reactive pupils

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9
Q

Prion dz

A

Insidious onset, but RAPID PROGRESSION

Myoclonus, Ataxia

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10
Q

Examples of Prion

A

Creutzfeldt-Jacob

Mad Cow dz

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11
Q

Cholinesterase inhibitors to tx dementia

A

Aricept
Razadyne
Namenda

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12
Q

NMDA antagonist to tx Dementia

A

Namenda

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13
Q

Characteristics of Alcoholism

A
it's a PRIMARY dz
Progressive and fatal
Impaired control
Preoccupation
Adverse consequences
Denial
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14
Q

Four features of Alcoholism

A

Craving
Impaired control
Physical dependence
Tolerance

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15
Q

Bio-Psycho-Social model of Alcoholism

A

Bio (genetics, cells0
Psycho (cognitive, behavior)
Social (environment, inner circle)

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16
Q

Executive control

A

Prefrontal cortex

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17
Q

Nucleus Accumbens

A

Dopamine system target

alcoholism

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18
Q

Imbalance b/w

A

Pleasure and Control

in alcoholism

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19
Q

Dopamine system

A

Nucleus accumbens

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20
Q

Genetic pre-D for Alcoholism

A

in the Dopamine Transporter

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21
Q

Genetic pre-D for Alcoholism

A

Compulsivity is what runs in the family, surfaces as Alcoholism

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22
Q

Screening tools for Alcoholism

A

CAGE or AUDIT

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23
Q

At risk users

“substance misuse”

A

> 14 /week for men

> 7 /week for females

24
Q

Problem users

“substance abuse”

A

experience problems related to use

health, legal, family, school, work

25
Dependent users | "addiction"
increased loss of control, alc related consequences, physiological dependence
26
CAGE screening
4 questions | if get +1, consider going to AUDIT
27
ADUT screening
best for Alcohol abuse, problem drinking 10 Qs more sensitive and specific
28
CAGE questionarre
4 questions: - feel like ought to cut down - annoyed by others telling u to quit - feel guilty - need to use first in morning
29
Level of drinking
``` Abstinence Experiment Social/recreational Habit Abuse Addiction ```
30
Diagnostic criteria of Alcoholism
2+ within 12 months
31
4 categories of Alcoholic diagnostic criteria
Impaired Control Social impairment Risky Use Pharm
32
3 motivational techniques for getting patient into Alcohoism treatment
Confrontation Empathy Offering Hope
33
How much is too much alcohol?
Tolerance + Dependence + Compulsion = get help
34
In patient DETOX of alcoholism
Benzos ("pam") Lorazepam PhenoBARBitol
35
Nutritional support for Alc DETOX
Thiamine
36
Extended tx for Alcoholism
Disulfuram Acamprosate Naltrexone
37
Methadone or Buprenorphine (Suboxone) are used to treat
Opioid addiction
38
How does Suboxone work
Bind to mu receptor (same as morphine) but doesn't produce same effects weak partial agonist reduce Craving and Prevents euphoria (low abuse potential)
39
3 derivatives of opium
Morphine Codeine Thebaine
40
Morphine divides into (3)
Hydromomorphone Oxymorphone Heroin
41
Thebaine divides into (2)
Oxycodone | Etorphine
42
Synthetic opiates
``` Methadone Meperidine Propoxyphene LAAM Fentanyl ```
43
Dysphoria
Kappa
44
Sedation
Mu and Kappa
45
Dependencee
Mu and Kappa
46
Rick of continued opioid use increases at
4-5 DAYS
47
Drug seeking behavior
The over reporting/ over fabrication of sx
48
Common drugs that are sought to abuse
``` Euphoria Rapid onset/high potency/short duration High purity Water soluble Brand name ```
49
Specific drugs that are often abused
``` Opiates -percocet, vicodin, morphine Sleep aids -Benzos: xanax, valium, ambien -barbs ```
50
Opioid use disorder
have TWO of criteria
51
Opioid use disorder
Early >3 months | Late remission >12 months
52
Severity of OUD
mild 2-3 sx moderate 4-5 sx severe 6+
53
Tx of OUD
Narcan for OD Clonidine for SNS overstimulation Methadone taper
54
Extended tx of OUD
Methadone or Buprenor (Suboxone)
55
Suboxone
binds to same Mu receptors reduces craving and prevents euphoria long acting, decreased respiratory depression
56
Suboxone requires
DEA 'X' license/ MAT training