friday flashcards

1
Q

alzheimers

A

strong MEMORY impairment

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2
Q

Frontotemporal degeneration

A

Behavioral or Language variant

loss of sympathy, decline in speech

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3
Q

Lewy Body dz

A

Visual Hallucinations
REM sleep disorder

SEVERE sensitivity to Antipsychotics

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4
Q

Dont give Antipsychotics to

A

pts with Lewy Body dz

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5
Q

Vascular

A

dementia brought on by TIA or Stroke

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6
Q

Vascular dementia, will see on MRI

A

White matter hyperintensity

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7
Q

TBI (concussion)

A

LOC, post trauma amnesia, confused, neuro signs

can be acute or repeated trauma

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8
Q

Poorer outcomes w TBI are

A

repeated concussion
>40 YO
poor motor fx
non-reactive pupils

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9
Q

Prion dz

A

Insidious onset, but RAPID PROGRESSION

Myoclonus, Ataxia

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10
Q

Examples of Prion

A

Creutzfeldt-Jacob

Mad Cow dz

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11
Q

Cholinesterase inhibitors to tx dementia

A

Aricept
Razadyne
Namenda

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12
Q

NMDA antagonist to tx Dementia

A

Namenda

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13
Q

Characteristics of Alcoholism

A
it's a PRIMARY dz
Progressive and fatal
Impaired control
Preoccupation
Adverse consequences
Denial
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14
Q

Four features of Alcoholism

A

Craving
Impaired control
Physical dependence
Tolerance

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15
Q

Bio-Psycho-Social model of Alcoholism

A

Bio (genetics, cells0
Psycho (cognitive, behavior)
Social (environment, inner circle)

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16
Q

Executive control

A

Prefrontal cortex

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17
Q

Nucleus Accumbens

A

Dopamine system target

alcoholism

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18
Q

Imbalance b/w

A

Pleasure and Control

in alcoholism

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19
Q

Dopamine system

A

Nucleus accumbens

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20
Q

Genetic pre-D for Alcoholism

A

in the Dopamine Transporter

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21
Q

Genetic pre-D for Alcoholism

A

Compulsivity is what runs in the family, surfaces as Alcoholism

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22
Q

Screening tools for Alcoholism

A

CAGE or AUDIT

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23
Q

At risk users

“substance misuse”

A

> 14 /week for men

> 7 /week for females

24
Q

Problem users

“substance abuse”

A

experience problems related to use

health, legal, family, school, work

25
Q

Dependent users

“addiction”

A

increased loss of control, alc related consequences, physiological dependence

26
Q

CAGE screening

A

4 questions

if get +1, consider going to AUDIT

27
Q

ADUT screening

A

best for Alcohol abuse, problem drinking
10 Qs

more sensitive and specific

28
Q

CAGE questionarre

A

4 questions:

  • feel like ought to cut down
  • annoyed by others telling u to quit
  • feel guilty
  • need to use first in morning
29
Q

Level of drinking

A
Abstinence
Experiment
Social/recreational
Habit
Abuse
Addiction
30
Q

Diagnostic criteria of Alcoholism

A

2+ within 12 months

31
Q

4 categories of Alcoholic diagnostic criteria

A

Impaired Control
Social impairment
Risky Use
Pharm

32
Q

3 motivational techniques for getting patient into Alcohoism treatment

A

Confrontation
Empathy
Offering Hope

33
Q

How much is too much alcohol?

A

Tolerance + Dependence + Compulsion = get help

34
Q

In patient DETOX of alcoholism

A

Benzos (“pam”)
Lorazepam
PhenoBARBitol

35
Q

Nutritional support for Alc DETOX

A

Thiamine

36
Q

Extended tx for Alcoholism

A

Disulfuram
Acamprosate
Naltrexone

37
Q

Methadone or Buprenorphine (Suboxone) are used to treat

A

Opioid addiction

38
Q

How does Suboxone work

A

Bind to mu receptor (same as morphine) but doesn’t produce same effects

weak partial agonist

reduce Craving and Prevents euphoria (low abuse potential)

39
Q

3 derivatives of opium

A

Morphine
Codeine
Thebaine

40
Q

Morphine divides into (3)

A

Hydromomorphone
Oxymorphone
Heroin

41
Q

Thebaine divides into (2)

A

Oxycodone

Etorphine

42
Q

Synthetic opiates

A
Methadone
Meperidine
Propoxyphene
LAAM
Fentanyl
43
Q

Dysphoria

A

Kappa

44
Q

Sedation

A

Mu and Kappa

45
Q

Dependencee

A

Mu and Kappa

46
Q

Rick of continued opioid use increases at

A

4-5 DAYS

47
Q

Drug seeking behavior

A

The over reporting/ over fabrication of sx

48
Q

Common drugs that are sought to abuse

A
Euphoria
Rapid onset/high potency/short duration
High purity
Water soluble
Brand name
49
Q

Specific drugs that are often abused

A
Opiates
-percocet, vicodin, morphine
Sleep aids
-Benzos: xanax, valium, ambien
-barbs
50
Q

Opioid use disorder

A

have TWO of criteria

51
Q

Opioid use disorder

A

Early >3 months

Late remission >12 months

52
Q

Severity of OUD

A

mild 2-3 sx
moderate 4-5 sx
severe 6+

53
Q

Tx of OUD

A

Narcan for OD
Clonidine for SNS overstimulation
Methadone taper

54
Q

Extended tx of OUD

A

Methadone or Buprenor (Suboxone)

55
Q

Suboxone

A

binds to same Mu receptors

reduces craving and prevents euphoria

long acting, decreased respiratory depression

56
Q

Suboxone requires

A

DEA ‘X’ license/ MAT training