Psych Flashcards

1
Q

Classical conditioning

  • what is it
  • example
A
  • learning in which a natural response is elicited by a conditioned response that previously was presented in conjunction with an unconditioned stimulus
  • salivating when a bell is rung because it was previously presented with food
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2
Q

Operant conditioning

  • what is it
  • reinforcement
  • punishment
  • extinction
A
  • learning in what action is elicited because it produces a punishment or reward
  • behavior is followed by reward
  • repeated application of aversive stimulus or removal of reward to extinguish unwanted behavior
  • Discontinuation of reinforcement eliminates behavior
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3
Q

Transference and countertransference

- what are they and ex

A
  • transference: pt projects feelings about formative or other important persons onto physician (psychiatrist is seen as parent
  • counter: doctor projects feelings about another person onto pt (pt reminds physician of younger sibling)
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4
Q

Ego defenses immature

  • acting out: what is it; ex
  • denial: what is it; ex
  • displacement: what is it; ex
  • dissociation: what is it; ex
  • fixation
  • idealization
  • identification
  • intellectualization
  • isolation
  • passive aggression
  • projection
  • rationalization
  • reaction formation
  • regression
  • repression
  • splitting
A
  • acting out: subconsciously coping w/ stressors or emotionl conflict using actions rather than reflections or feelings; pt skips therapy apt after deep discomfort from dealing w/ past
  • denial: avoiding awareness of some painful reality; pt w/ CA plans a full-time work schedule despite being warned or significant fatigue during chemo
  • displacement: redirection of emotions or impulses to neutral person or object; teacher is yelled at by principal and instead of confronting principal the teacher yells at husband later
  • dissociation: temporary, drastic change in personality, memory, consciousness or motor behavior to avoid emotional stress; victim of sexual abuse suddenly appear numb when exposed to her abuser
  • fixation: partially remaining at a more childish level of development; surgeon throwing tantrum bc case took too long
  • idealization: expressing extremely positive thoughts of self and others while ignoring negative thoughts; pt boasts about physician and accomplishments while ignoring flaws
  • identification: largely unconscious assumption of characteristics, qualities, or traits of other person or group; resident starts to put stethoscope in pocket like fav physician instead of wearing around neck like he used to
  • intellect: using facts and logic to emotionally distance oneself from stressful situation; pt diagnosed w/ CA discussed pathophys of dx
  • isolation: separating feelings from ideas and events; describing murder in graphic detail w/o emotion
  • passive: demonstrating hostile feelings in confrontational manner; disgruntled employee repeatedly late
  • projection: attributing an unacceptable internal impulse to external source; man who wants to cheat on wife accuses his wife being unfaithful
  • rationalization: asserting plausible explanation for events that actually occurred for other reasons, usually to avoid self blame; after getting fired claiming that job wasn’t important
  • reaction formation: replacing warded off idea or feeling w/ emphasis on its opposite; a patient w/ lustful thoughts enters a monastery
  • regression: involuntarily turning back the maturational clock to earlier modes of dealing with the world; seen in children under stress such as bedwetting
  • repression: involuntarily withholding an idea or feeling from conscious awareness; 20 yr old does not remember going to counseling during parents divorce 10 yrs earlier
  • splitting: believing people are either all good or all bad at different times; pt says all nurses are cold and insensitive but doctors are warm and friendly
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5
Q

Ego defenses mature

  • sublimation
  • altruism
  • suppression
  • humor
A
  • sublimation: replacing an unacceptable wish w/ course of action that is similar to wish but socially acceptable; teenagers aggression bc of parents high expectation is channeled into excelling in sports
  • altriusm: alleviating negative feelings via unsolicited generosity which provides gratification; mafia boss makes large donation to charity
  • suppression: intentionally withholding an idea or feeling from conscious awareness; choosing to not worry about big game until time to plat
  • humor: lightheartedly expressing uncomfortable feelings to sift internal focus away from distress; nervous medical student jokes about boards
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6
Q

Infant deprivation effects

  • deprivation of
  • results in
A
  • affection

- failure to thrive, poor language, lack of basic trust, reactive attachment disorder, disinhibited social engagement

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7
Q

Child abuse

  • physical
  • sexual
  • emotional
A
  • fractures, bruises, burns, w/ injuries in diff stages of healing; usually biological mothers; 40% deaths related to child abuse or neglect occur in children < 1 yr old
  • STI, UTI, genital or oral trauma, children often exhibit sex knowledge or behavior incongruent w/ age; known to victim, male, peak is 9 to 12
  • babies or young children may lack bond w/ caregiver but are overly affectionate w/ less familiar adults, older children prone to angry outbursts; male or female caregivers; 80% of young adult victims of childhood abuse meet criteria for > 1 psych illness by age 21
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8
Q

Child neglect

  • what is it
  • most common form
  • what has to be done
A
  • failure to provide a child w/ adequate food, shelter, supervision, education, and or affection
  • poor hygiene, malnutrition, withdrawal
  • must be reported
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9
Q

Vulnerable child syndrome

  • what is it
  • happens after
  • sxs
A
  • parents perceive the child as susceptible to illness of injury
  • serious illness or life threatening event
  • missed school or overuse of med services
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10
Q

Childhood disorders

  • ADHD: age, what is it, sxs
  • autism: sxs
  • conduct disorder: what is it
  • disruptive mood dysregulation disorder: onset, what is it, tx
  • intellectual disability: what is it
  • oppositional defiant disorder: what is it, tx
  • selective mute: onset, what is it, tx
  • separation anxiety disorder: what is it, sequlae
  • specific learning disorder: onset, what is it, tx
  • tourette syndrome: age, what is it, coprolalia
A
  • ADHD: onset before 12, greater than 6 months of limited attention span and poor impulse control; hyperactivity, impulsivity or inattention
  • Autism: Poor social interaction, communication deficits, repetitive behaviors; can have intellectual disabilities
  • Conduct: repetitive, pervasive behavior violating societal norms (aggression towards people, destruction of property, theft)
  • Disruptive: onset before age 10; severe recurrent temper outbursts out of proportion to situation; child constantly angry and irritable between outbursts; tx: stimulant and anti-psych
  • Intellectual: global cog deficits that affect reasoning, memory, abstract thinking
  • Opp: enduring pattern of hostile, defiant behavior toward authority figures w/o serious violation of social norms; tx: psychotherapy
  • selective mute: onset before age 5; anxiety lasting more than 1 month involving refraining of speech in certain situations; tx: behavioral therapy
  • separation anxiety: overwhelming fear of separation from home or attachment figure lasting more than 4 wks; can be normal behavior up to age 3-4, can lead to factitious physical complaints to avoid school; tx: CBT
  • specific learning: onset during school age years; inability to acquire or use information from specific subject near age expected proficiency for more than 6 months despite intervention; tx: academic support, counseling
  • tourette: before 18 yrs; sudden, rapid, recurrent, non-rhythmic motor or vocal tics that persist for more than a year; coprolalia (involuntary obsence speech); tx: high potency anti-psych
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11
Q

Amnesia

  • retrograde
  • anterograde
  • korsakoff syndrome
A
  • inability to remember things that occurred before CNS insult
  • inability to remember things that occurred after a CNS insult
  • amnesia caused by vitamin B1 deficiency and associated w/ destruction of mamillary bodies
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12
Q

Dissociative disorder

  • depersonalization
  • dissociative amnesia
  • dissociative identity disorder
A
  • persistent feelings of detachment or estrangement from ones own body, thoughts, perceptions and actions; intact reality testing
  • inability to recall important personal info, usually subsequent to severe trauma or stress
  • formerly known as multiple personality disorder; presence of more than 2 distinct identities or personality states; more common in women; associated w/ sex abuse, PTSD, depression, substance abuse
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13
Q

Delirium

  • what is it
  • sxs
  • cause
  • when
  • tx
A
  • waxing and waning level of consciousness with acute onset
  • disorganized thinking, hallucinations, misperceptions, disturbance in sleep and wake cycles
  • usually secondary to other identifiable illness
  • most common presentation of altered mental status in inpatient setting especially in ICU
  • antipsychotics
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14
Q

Pscyhosis

  • delusions
  • disorganized thoughts
  • hallucinations
A
  • distorted perception of reality
  • false, fixed, idiosyncratic beliefs that persist despite evidence of contrary and are not typical of pts culture or religion
  • perceptions in absence of external stimuli
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15
Q

Types of hallucinations

  • auditory
  • visual
  • tactile
  • olfactory
  • gustatory
  • hypnagogic
  • hypnopompic
A
  • more commonly due to psych illness
  • more commonly due to medical illness
  • common in EtOH withdrawal and stimulant use
  • often occur as aura of temporal lobe epilepsy
  • rare, but seen in epilepsy
  • occurs while going to sleep, sometimes seen in narco
  • occurs while waking from sleep
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16
Q

Schizophrenia

  • positive
  • negative
  • dx
  • caused by
  • risks
  • TX
  • brief psychotic disorder
  • schizophreniform disorder
  • schizoaffective disorder
  • delusional disorder
  • schizotypal personality disorder
A
  • hallucination, delusions
  • flat or blunted affect
  • delusion, hallucination, disorganized speech, disorganized behavior, negative sxs; need 2 or more
  • increase in dopamine and serotonin
  • male (teens to early 20s) and female (20s to 30s)
  • cannabis
  • atypical antipsychotics are first line
  • 1 or more sxs lasting less than a month
  • more than 2 sxs lasting 1-6 months
  • sxs of both schizo and mood disorders, must have 2 weeks of schizo sxs w/o manic or depressive episode
  • cluster A personality that falls on schizo spectrum
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17
Q

Mood disorder

A
  • characterized by abnormal range of moods or internal emotional states and loss of control over them
  • episodic superimposed psych features may be present
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18
Q

Manic episode

  • what is it
  • sxs
A
  • distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increase in acitivty or energy lasting more than a week
  • distractibility, impulsivity, grandiosity, flight of ideas, agitation, decrease need for sleep, talkativeness or pressured speech
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19
Q

Hypomanic episode

  • what is it
  • does not contain
  • time frame
A
  • similar to manic episode but not severe enough to caused marked impairment in socal or occupational functioning or to necessitate hospitalization
  • no psych features
  • lasts less than 4 days
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20
Q

Bipolar disorder

  • I
  • II
  • between episodes
  • suicide
  • tx
  • cyclothymic disorder
A
  • > 1 manic episode +/- hypomanic or depressed episode
  • > 1 hypomanic and depressive episode
  • mood and function normalize
  • high risk
  • mood stabilizers: lithium, valproic acid, lamotrigene) or atypical antipschotics
  • milder form of bipolar fluctuating between mild depressive and hypomanic sxs; must last more than 2 years w/ sxs present at least half the time with any remission shorter than 2 months
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21
Q

Major depressive Disorder

  • what is it
  • screen for
  • sxs
  • MDD w/ psch fx
  • persistent depressive disorder
  • MDD w/ seasonal pattern
A
  • episode of 5 or more of 9 characteristic sxs lasting more than 2 weeks
  • hx of manic or hypomanic episodes to r/o bipolar
  • Depressed mood, sleep disturbance, loss of interest, guilt/feeling of worthlessnesss, energy loss/fatigue, concentration problems, appetite/weight changes, psychomotor retardation, suicidal ideation
  • MDD w/ hallucinations or delisions; antidepressant w/ atypical antipsych
  • 2 depressive sxs lasting more than 2 years w/o being consecutive for more than 2 months
  • lasting more than 2 years with more than 2 depressive episodes associated with seasonal pattern and absence of nonseasonal depressive episodes
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22
Q

Depression w/ atypical fx

  • mood
  • other sxs
  • TX
A
  • mostly depression but can have transient moods in response to positive events
  • hypersomnia, hyperphagia, leaden paralysis
  • CBT and SSRI
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23
Q

Peripartum mood disturbances

  • maternal blues: incidence, sxs, when, resolves, tx
  • MDD w/ peripartum onset: incidence, sxs
  • postpartum psychosis: incidence, what is it, risk, tx
A
  • 50-85% incidence rate; depressed affect, tearful, fatigue; 2-3 days after delivery; resolves within 10 days; tx: supportive
  • 10-15%; depressed affect, anxiety, and poor concentration for > 2 wks; CBT and SSRI
  • 0.1 - 0.2%; mood congruent delusions, hallucinations, and thoughts of harming the baby or self; hx bipolar/psych disorder, first pregnancy, family hx, recent discontinuation of psychotropic meds; hospitalization and initiation of atypical antipsychotic
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24
Q

Grief

  • 5 stages
  • other sxs
  • duration
  • complicated
A
  • denial, anger, bargaining, depression, acceptance
  • shock, guilt, sadness, anxiety, yearning
  • 6-12 months
  • persistent, causes functional impairment
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25
Q

Electroconvulsive therapy

  • what is it
  • side effects
A
  • induces tonic-clonic seizure while pt under anesthesia and NM blockade
  • disorientation, headache, amnesia resolving in 6 mnths
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26
Q

Anxiety

  • what is it
  • tx
A
  • inappropriate experience of fear/worry and physical manifestations incongruent w/ magnitude of stressor
  • not attributable to other psych disorder
  • CBT, SSRI, CNRI
27
Q

Panic Disorder

  • what is it
  • time frame
  • sxs
  • side effect
  • tx
A
  • recurrent attack involving intense fear and discomfort , +/- trigger
  • attacks peak in 10 min
  • palpitation, paresthesia, depersonalization, abdominal distress/ nausea, intense fear of dying/ losing control
  • requires attacks followed by more than 1 month of 1 or more of persistent concern, worrying about consequences, behaviorial changes related to attacks
  • CBT, SSRI, venlafaxine
28
Q

Phobia

A
  • severe, persistent fear or anxiety due to presence or anticipation of specific object or situation
  • CBT
  • exaggerated fear of embarrassment in social situation; for performance type use Beta blocker
  • irrational fear while facing or anticipating, closed spaces, lines, crowds, public transport; some refuse to leave homes; associated w/ panic disorder
29
Q

Phobia

  • what is it
  • tx
  • social anxiety: what is it
  • agoraphobia: what is it
A
  • severe, persistent fear or anxiety due to presence or anticipation of specific object or situation
  • CBT
  • exaggerated fear of embarrassment in social situation; for performance type use Beta blocker
  • irrational fear while facing or anticipating, closed spaces, lines, crowds, public transport; some refuse to leave homes; associated w/ panic disorder
30
Q

Generalized Anxiety

A
  • excessive anxiety and worry about different aspects of daily life for most days for > 6 months
  • restlessness, irritability, sleep disturbance, fatigue, muscle tension, diff concentrating
  • CBT, SSRI, SNRI
31
Q

OCD

  • what is it
  • explanation
  • tx
A
  • obsessions that cause severe distress, relieved by compulsions
  • recurring thoughts, feelings, sensations relieved by performance of repetitive actions
  • CBT and SSRI
32
Q

Trichotillomania

  • what is it
  • sxs
  • age
  • tx
A
  • compulsively pulling out hair
  • areas of thinning hair or baldness on any area of body
  • childhood
  • psychotherapy
33
Q

Trauma and stress disorders

  • adjustment disorder: what is it, lasts, classified, tx
  • PTSD: what is it, sxs, tx
A
  • emotional sxs that occur w/i 3 months of identifiable psychosocial stressor; lasts less than 6 months once stressor has ended; then classified as GAD; CBT, SSRI
  • experience life threatening situation that causes hyper arousal, avoidance of stimuli, intrusive re-rexperiencing of event causing changes in cognition or mood; CBT, SSRI, venlafaxine
34
Q

Cluster A personality disorders

  • schizoid
  • schizotypal
A
  • voluntary social withdrawal, limited emotional expression, content w/ social isolation
  • eccentric appearance, odd beliefs / magical thinking, interpersonal akwardness
35
Q

Cluster B personality disorders

  • antisocial
  • borderline
  • histrionic
  • narcissistic
A
  • disregard for rights of others w/ lack of remorse; involves criminality, impulsivity, hostility, manipulation
  • unstable mood and interpersonal erlationships, fear of abandonment, impulsive, slef-mutilating, suicidal, sense of emotional emptiness
  • attention seeking, dramatic speech and emotional expression, shallow and labile, sexually provocative
  • grandiosity, sense of entitlement, lacks empathy and requires excessive admiration, often demands the best and reacts to criticism w/ rage or defensiveness, fragile self esteem
36
Q

Cluster C personality disorders

  • avoidant
  • obsessive-compulsive
  • dependent
A
  • hypersensitive to rejection and criticism, socially inhibited, timid, feeling of inadequacy, desires relationships w/others
  • preoccupation w/ order, perfectionism, and control, behvaior is consistent w/ ones own beliefs attitudes
  • excessive need for support, low self confidence
37
Q

Malingering

  • what is it
  • sxs
A
  • sxs intentional and motivation is intentional
  • pt consciously fakes, profoundly exaggerates, or claims to have a disorder in order to attain a specific secondary gain such as avoiding work or obtaining compensation
  • poor compliance w/ tx or follow up of labs
38
Q

Factitious Disorders

  • difference from malingering
  • imposed on self
  • imposed on other
A
  • sxs intentional but motivation is unconscious; pt created physical and/or psysch sxs in order to assume sick role and get medical attention and sympathy
  • munchausen syndrome; factitous disoswe w/ hx of mult hospital admissions and willingness to undergo invasive procedures
  • illness in child or elderly caused or fabricated by caregiver; motivation is to assume a sick role by proxy
39
Q

Somatic Sxs and related disorder

  • classification
  • somatic sxs: what is it; tx
  • conversion disorder: what is it
  • illness anxiety disorder: other name, what is it
A
  • sxs are unconscious, motivation is unconscious
  • variety of body complaints lasting months to years, associated w/ excessive, persistent thoughts and anxiety about sxs; reg office visits w/ same physician in combo w/ psychotherapy
  • loss of sensory or motor function following acute stressor
  • hypochondriasis, preoccupation w/ acquiring or having serious illness, despite medical eval and reassurance
40
Q

Eating disorder

  • anorexia
  • refeeding syndrome
  • bulmia
  • binge eating
  • pica
A
  • intense fear of weight gain, over-evaluate thinness and body image distortion -> calorie restriction and weight loss resulting in inappropriately low body weight; binge and purge type, restricting type
  • occurs in significalty malnourished pts with sudden increase in calorie intake; food intake causes increase in insulin causes hypo-phosphatemia, kalemia, magnesmia -> cardiac complication, rhabdomyolysis, seizure
  • recurring episodes of binge eating w/ compensatory purging behaviors at least weekly over 3 months; BMI normal or slightly over weight; psychotherapy, nutrition rehab, anti-depressants
  • resurring episodes of binge eating w/o purging behaviors at leat weekly over last 3 months; psychotherapy, SSRI
  • recurring episode of eating non-food substances over 1 month that are not culturally or developmentally recognized as normal; common in children or pregnancy; malnutrition, anemia, developmental disabilities, emotional trauma; psych therapy and nutritional rehab
41
Q

Gender dysphoria

  • what is it
  • transgender
  • transvestism
A
  • significant incongruence between ones experienced gender and gender assigned at birth lasting > 6 mnths and leading to persistent distress
  • desiring and making lifestyle changes to live as a different gender
  • deriving pleasure from wearing clothes of opp sex
42
Q

Sex dysfunction

A
  • includes sex desire disorders (hypoactive, or sex aversion) , sex arousal disorder (ED), orgasmic disorder (anorgasmia, premature ejaculation), sex pain disorder (dyspareunia, vaginismus)
43
Q

Sleep terror disorder

A
  • periods of inconsolable terror w/ screming in middle of night
  • children
  • during slow wave/ deep non REM sleep w/ no memory of arousal episode
44
Q

Enuresis

  • what is it
  • first line tx
  • refractory cases
A
  • urinary incontinence more than 2x a week for more than 3 months in person older than 5 years
  • behavioral modification and positive reinforcement
  • bed wetting, oral desmopressin
45
Q

Narcolepsy

  • what is it
  • caused by
  • tx
A
  • excessive daytime sleepiness w/ recurrent episodes of rapid-onset, overwhelming sleepiness more than 3x a week for the last 3 months
  • due to decrease in orexin production in lat hypothalamus and dysregulated sleep-wake cycles
  • good sleep hygiene, daytime stimulants, and nightime sodium oxybate
46
Q

Stage in overcoming addiction

A
  • pre-contemplation: denying problem
  • contemplation: acknowledges problem, but unwilling to change
  • preparation/determination: preparing for behavioral changes
  • action/willpower: changing behavior
  • maintenance: maintaining behavior
  • relapse
47
Q

Psych emergencies

  • serotonin syndrome
  • hypertensive crisis
  • neurleptic malignant syndrome
  • delirium tremens
  • acute dystonia
  • lithium tox
  • TCA tox
A
  • caused by any drug that increase 5-HT; increase in activity (clonus, hyper relfaxia, tonia, tremor, seizure), autonomic instability (hyperthermia, diarrhea), altered mental status; cyproheptadine
  • eating tyramine rich foods, hypertensive crisis, phentolamine
  • antipsychotic and genetic predisposition; myoglobinuria, fever, encephalopathy, increase enzymes; dantrolene, dopamine agonist
  • alcohol withdrawl - 2 to 4 days after last drink; altered mental status, hallucinations, autonomic hyperactivity, anxiety, seizure, tremor; benzos
  • typical anti-convulsants; sudden onset of muscle spasms, stiffness, and/or oculogyric cirisis; benztropine or diphenhydamine
  • high lithium dosage or decreased kidney elimination; nausea, vomitting, slurred speech, hyper-reflexia, seizures; discontinue lithium hydrate aggressively w/ isotonic NA Cl
  • TCA overdose, resp depression, hyperpyrexia, prolonged QT; tuppostive tx, NaHCO3, activated charcoal
48
Q

Depressive drugs

  • alcohol: intoxication
  • barbituates: intoxication, intoxication tx, withdrawal
  • benzos: intoxication; withdrawal
  • opioids: intoxication; intox tx; withdrawal
A
  • emotional lability, decreased anxiety, sedation, behavioral dis-inhibition, resp depression
  • resp depression; tx: sxs management; delirium and life threatening CV collapse
  • ataxia, minor resp depression; flumazenil; sleep disturbances, depression
  • euphoria, resp and CNS depression, decrease gag reflex, pupillary constriction; naloxone; sweating, dilated pupils, piloerection, rhinorrhea, lacrimation
49
Q

Stimulant drugs

  • amphetamine: intoxication, tx for intoxication
  • caffeine: intoxication, withdrawal
  • cocaine: intoxication, tx of intoxication
  • nicotine: intoxication, withdrawal
A
  • euphoria, grandiosity, pupillary dilation, prolonged wafefilness and attention, severe cardiac arrest, seizure; benzos
  • restlessness, increased diuresis, muscle twitching; headache, difficulty concentrating, flu-like sxs
  • impaired judgement, pupillary dilation, hallucination, paranoia, angina, sudden cardiac death; benzo
  • restlessness; irritability, anxiety, restlessness, difficulty concentrating; nicotine patch, gum, lozenges
50
Q

Hallucinogens

  • Lysergic acid diethylamide
  • marijuana: psych effect, physical effects, drug form - used for
  • MDMA (ecstasy)
  • Phenylcyclidine (PCP)
A
  • perceptual distortion, depersonalization, anxiety, paranoia, psychosis, flashbacks
  • euphoria, anxiety, paranoid delusion, perceptions of slowed time; increase appetite, dry mouth, conjunctiva injection, hallucinations; dronabinol - used as anti-emetic and appetite stimulant
  • hallucinogenic stimulant; euphoria, disinhibition, hyper activity, distorted sensory and time perception, bruxism; life threatening effects include hypertension, tachycardia, hyperthermia, hyponatremia, serotonin syndrome
  • violence, impulsivity, psychomotor agitation, nystagmus, tachycardia, hypertension, analgesia, psychosis, delirium, seizures
51
Q

Wernicke-kosakoff syndrome

  • deficiency
  • encephalopathy
  • syndrome
  • associated w
  • TX
A
  • vit B1
  • confusion, opthalmoplegia, ataxia
  • memory loss, confabulation, personality change
  • periventricular hemorrhage/ necrosis of mammillary bodies
  • IV vitamin B1
52
Q

Meds for psych conditions

  • ADHD
  • alcohol withdrawal
  • bipolar
  • bulimia
  • depression
  • generalized anxiety disorder
  • OCD
  • Panic disorder
  • PTSD
  • Schizophrenia
  • Social anxiety disorder
  • Tourettes
A
  • stimulants
  • benzos
  • lithium, valproic acid, carbamazepine, lamotrigine
  • SSRI
  • SSRI
  • SSRI, SNRI
  • SSRI, venlafaxine
  • SSRI, venlafaxine, benzo
  • SSRI, venlafaxine
  • atpical antipsychotics
  • SSRI
  • Antipsychotics
53
Q

Central Nervous system stimulants

  • examples
  • MOA
  • indications
  • side effects
A
  • methylphenidate, dextroamphetamine, methamphetamine, lisdexamfetamine
  • increase catecholamines in synaptic cleft
  • ADHD, narcolepsy, binge eating
  • nervousness, anxiety, insomnia, anorexia
54
Q

Typical antipscyhoctics

  • examples
  • MOA
  • indications
  • high potency
  • low potency
  • adverse effect: lipids, enodcrine, metabolic, anti-muscarinic, anti-histamine, alpha1 blockade, cardiac, opthalmologic, extra pyramidal
A
  • haloperidol, pimozidem
  • block D2 receptor
  • schizophrenia, psychosis, bipolar disorder, delirium, tourette, huntington
  • haloperidol, trifluoperazine
  • cholorpromazine, thioridazine
  • lipid soluble -> stored in body fat -> slow to be removed from body; dopamine antagonist -> increase in prolactin; dyslipidemia, weight gain, hyperglycemia; dry mouth, constipation; sedation; orthostatic hypotension; QT prolongation; corneal and retinal deposits; acute dystonia, restlessness, bradykinesia
55
Q

Atypical antipsychotics

  • examples
  • MOA
  • indications
  • side effects
A
  • asenapine, clozapine, olanzapine, quetiapine; iloperidone, paliperidone, risperidone
  • Most are 5-HT and D2 antagoinst
  • schizo, bipolar, OCD, anxiety, depression, mania, tourette
  • prolonged QT
56
Q

Lithium

  • MOA
  • indications
  • side effects
A
  • inhibits phosphoinositol
  • mood stabilizer for bipolar
  • tremor, thyroid abnormalities, polyuria, teratogens, ebstein anomaly
57
Q

Buspirone

  • MOA
  • indication
  • time length
  • does not interact
A
  • stimulates 5-HT A1 receptors
  • generalized anxiety
  • 1-2 wks
  • with EtOH
58
Q

SSRI

  • examples
  • MOA
  • indications
  • side effect
A
  • fluoxetine, paroxetine, sertraline, escitalopram
  • Inhibits 5-HT re-uptake
  • depression, generalized anxiety, panic disorder, OCD
  • serotonin syndrome, GI distress, SIADH, sex dysfunction
59
Q

SNRI

  • examples
  • MOA
  • indications
  • side effect
A
  • venlafaxine, duloxetine
  • inhibits 5-HT and NE uptake
  • depression, anxiety, diabetic neuropathy
  • increase BP, stimulant effects, sedation, nausea
60
Q

TCA

  • examples
  • MOA
  • indications
  • side effect
A
  • amitriptyline, nortriptyline, imipramine
  • inhibit 5-HT and NE uptake
  • MDD, peripheral neuropathy, chronic pain, migrain prophylaxis
  • sedation, alpha 1 blocker causing hypotension, convulsions, coma, cardiotoxicity
61
Q

Monoamine Oxidase Inhibitors

  • examples
  • MOA
  • indication
  • side effect
  • contraindicated
A
  • tranylcypromine, phenelzine, isocarboxazid
  • selective MAO inhibition -> increase levels of amine NT’s
  • atypical depression, anxiety, parkinsons
  • CNS stimulation -> hypertensive crisis
  • SSRI, TCA, St. John wort
62
Q

Atypical antidepressants

  • buproprion
  • mirtazapine
  • trazadone
  • varenicline
  • vilazodone
  • vortioxetine
A
  • inhibits NE and DA reuptake; used for smoking cessation; tox- stimulant effects, headache, seizure; favorable sex side effect profile
  • alpha 2 antagonist; 5-HT antagonist; sedation, increase appetite, weight gain
  • primarily blocks 5-HT, alpha 1 adrenergic, and H1 receptors; weakly inhibits 5-HT reuptake; used primarily for insomnia; sedation, nausea, postural hypertension
  • nicotinic ACh receptor agonist; smoking cessation; sleep disturbance and depressed mood
  • inhibits 5-HT reuptake; used for MDD; headache,, diarrhea, nausea, anti-cholinergic effects
  • inhibit 5-HT reuptake; used for MDD; nausea, sex dysfunction, sleep disturbances, anti-cholinergic effects
63
Q

Opioid withdrawal and detox

  • methadone
  • buprenorphine
  • naloxone
  • naltrexone
A
  • long acting oral opiate; used for heroin detox or long term maintenance
  • sublingual form used to prevent relapse
  • short acting opioid antagonist given IM, IV, or a nasal spray to treat acute opioid overdose, particularly to reverse respiratory and CNS depression
  • long acting oral opioid antagonist used after detox to prevent relapse