Psych Flashcards
How do you manage neuroleptic malignant syndrome?
Stop antipsychotic
Bromocriptine
What is the classic quadrate of post-traumatic stress disorder?
Reliving the situation
Avoidance
Hyperarousal
Emotional numbing
(prescent for > 1month)
How do you treat PTSD?
Trauma-focused CBT and/or Eye movement desensitization and reprocessing (in severe cases)
SSRI’s (2nd line)
What are Schneider’s first rank symptoms of schizophrenia?
Thought disorders
Delusional perceptions
Passivity
3rd person auditory hallucinations
What are the two pathways in the brain that relate to the symptoms of schizophrenia?
Mesolimbic - ↑dopamine causes positive symptoms
Mesocortical - ↓dopamine causes negative, cognitive and affective symptoms
What are the two pathways in the brain that relate to the side effects of antipsychotics?
Nigrostriatal - ↓ dopamine causes EPS & tardive dyskinesia
Tuberinfundibulum - ↓ dopamine causes hyperprolactinaemia
What are three examples of atypical (second-generation) antipsychotics?
Clozapine
Risperidone
Olanzapine
What are two examples of typical (first-generation) antipsychotics?
Haloperidol
Chlopromazine
How should lithium be monitored?
Sample should be taken 12 hours post-dose
After starting lithium levels should be checked weekly & after dose changes
Then when stable 3 monthly
TFT & U&E 6 monthly
What are some possible causes of lithium toxicity?
dehydration
renal failure
drugs: diuretics, ACE inhibitors/angiotensin II receptor blockers, NSAIDs & metronidazole.
Above what level is considered lithium toxicity?
Lithium toxicity = concentrations > 1.5 mmol/L.
What are the symptoms of lithium toxicity?
coarse tremor (a fine tremor is seen in therapeutic levels)
hyperreflexia
acute confusion
polyuria
seizure
coma
What are some of the common side-effects of lithium?
fine tremor
nephrotoxicity
hypothyroidism or hyperparathyroidism
weight gain & IIH
What are the medication options for mood stabilisers in bipolar disorder?
1st line is Lithium
2nd line is Sodium Valproate, Olanzapine or Quetiapine
What are the differences between grief and pathological grief?
Pathological < 12 months
Wants to die not just to be with loved one
Functional impairment
What questionnaire can be used in eating disorders?
SCOFF questionnaire
What are the features of neuroleptic malignant syndrome?
pyrexia
muscle rigidity
autonomic lability (hypertension, tachycardia & tachypnoea)
agitated delirium with confusion
What is neuroleptic malignant syndrome?
Condition seen in patients taking antipsychotic medication. It occurs within hours to days of starting an antipsychotic