PSY1003 WEEK 6 PART 1 Flashcards
what is needed to carry out animal research, and who regulates it
Home office (Replace, Refine, Reduce)
personal license (5 years), at establishment license lab
what is the animal (Scientific Procedures) act 1986
use of animals in experiements regulation by Home Office
who are BSMB
biological services management board- ensures law compliance, charges for animals, looking at current and future estates
what is CRISPR-CAS9 technology
allows selective alterations of specific parts of DNA, can revolutionise way we treat genetic diseases by selecting specific disease responsible genes
explain how optogenetic is disruptive tech
allows opsin protein placement into cell
currently researched into using for treating focal cortical epilepsy and alzeihmers
however uses adneoviruses so actively introducing viruses into the human brain
who has responsibility to ensure ethics are adhered to?
international = EU
national = government, UK Research and Innovation
specific body = medical research council
leading uni = russel
give the key 4 principles of medical research council guidelines
- research excellence and integrity
- respect, ethics and professional standards
- honesty and transparency
- openness and accountability
give some conflicts of interest when granting research fundings
financial (shares in company)
professional (working for same company)
personal (knowing individual)
prejudicial (competitor running for grant)
give 3 types of scientific malpractice
fabrication
falsification
plagiarism
(confidentiality, failure to acknowledge significant contribution, professional competition)
what are signs that research isnt going well
retraction from journal increases = more pressure to get paper published impacts data
decrease in replications (unable to reproduce study)
commercial pressures on uni
what are the pressures to be good
intrinsic vs extrinsic motivation
getting found out
whistleblowing
