Psoriasis

Question 1

Chronic Plaque Psoriasis Definition

Answer 1

-T cell mediated autoimmune disorder

Question 2

Chronic Plaque Psoriasis Epidemiology

Answer 2

• Plaque psoriasis in 90% of people affected

- Mostly presents before 35

Question 3

Chronic Plaque Psoriasis RFs

Answer 3

• FHx
• Environmental factors (sunlight improves it)
• Stress
• Some drugs

Question 4

Chronic Plaque Psoriasis Associated Diseases

Answer 4

• Psoriatic arthritis
• IBD
• Metabolic syndrome

Question 5

Chronic Plaque Psoriasis Presentation

Answer 5

• Bright pink lesion with overlying, well demarcated circular to oval bright red lesions
• With overlying silver scale
• Fissures can occur over joint lines
• New lesions often appear at site of injury or trauma (Köbners)
• Presents slightly differently in children (plaques less thick and less scaly, can appear in nappy region and flexural area, more common in face)
• Nail changes
• Acute episodes can develop into more severe disease (pustular or erythrodermic)

Question 6

Chronic Plaque Psoriasis Differentials

Answer 6

• Bowen’s
• Cutaneoud T-cell lymphoma
• Drug eruptions
• Lichen planus

Question 7

Chronic Plaque Psoriasis Investigations

Answer 7

-Rarely required

Question 8

Chronic Plaque Psoriasis Management

Answer 8

• Topical therapies first line (corticosteroids, vitD analogues, dithraniol, tar)
• Phototherapy second line
• Systemic biological therapies third line