PSIO202 Exam 4 - Urinary Concentration, Water Balance, and Micturition Flashcards
What are the two main things happening in a countercurrent mechanism?
countercurrent flow and osmotic gradient
What are the two types of countercurrent mechanisms, and describe them?
countercurrent multiplication: progressively increasing osmotic gradient in the interstitial fluid of the renal medulla
countercurrent exchange: enables oxygen delivery to cells of the renal medulla without loss of the osmotic gradient in the interstitial fluid of the renal medulla
What is the basic difference between concurrent flow and countercurrent flow?
concurrent - flowing same direction, start 0/100 and end at 50/50
countercurrent - slowing opposite directions, start 0/100 and end 100/0
What two factors create the osmotic gradient in the ISF of the renal medulla?
permeability differences in different sections of the nephron (descending = water, ascending = solutes, DCT and collecting duct = water only with ADH)
countercurrent flow of fluid through the ascending and descending limbs of the loop of henle
Because of the permeability differences and countercurrent flow in the loop of henle, there is a constant difference in ———.
These effects build on each other, making the loop of henle a ——— ———–.
osmolarity
countercurrent multiplier
What are the three major solutes involved in the osmotic gradient?
Na+ Cl- and urea
How does ADH effect the osmotic gradient?
- stimulates symporters in the thick ascending limb, which builds the osmotic gradient
- stimulates facultative reabsorption of water in the upper collecting duct
- stimulates water reabsorption and urea recycling in the lower collecting duct
What is the sequence of events in countercurrent multiplication?
- symporters in thick ascending limb build up the Na+ and Cl- in the renal medulla
- countercurrent flow through the descending and ascending limbs create an osmotic gradient
- cells in the collecting duct reabsorb water and urea (water via ADH, and urea because of permeability)
- urea is recycled and builds up in the renal medulla
What is the difference between exchange and countercurrent multiplication happening at the vasa recta?
countercurrent multiplication establishes the osmotic gradient which allows for motion between the vasa recta and the nephron
countercurrent exchange is the delivery of nutrients to the nephron cells, which is made possible by the previously established gradient
During countercurrent multiplication, the osmolarity outside the descending limb is (higher/lower) than the fluid inside, so water moves (in/out) of the tube into the ISF via osmosis.
higher outside
water moves out
When the tubule releases water into the ISF, urea in the tube becomes (more/less) concentrated in the tube. The duct cells (are/are not) permeable to urea, so it will…
becomes more concentrated in the tube
duct cells are permeable to urea
so it will diffuse out into the interstitial fluid of the medulla
When tubule fluid flows through the ascending limb, DCT, and cortical portion of the collecting ducts, what happens to urea, and why?
it remains in the tubule fluid because these cells are not permeable to urea
In the collecting ducts, what happens to urea?
urea concentration increases in the tubular fluid, so it diffuses out into the interstitial fluid of the medulla
In which structure does countercurrent exchange occur?
vasa recta
The vasa recta provides —– and —— to the renal medulla without washing out the ————.
oxygen and nutrients
osmotic gradient