Pruf2-I-logie

Question 1

This is a type of hypersensitivity rxn that involves TH2 cells, IgE antibody, mast cells, and eosinophils. Called “Atopic or Anaphylatic.”

Answer 1

Type 1 hypersensitivity (immediate)

Question 2

Hypersensitivity involving IgG, IgM antibodies against the cell surface or extracellular matrix antigens. Mechanism involves complement and Fc-receptor mediated recruitment/activation of leukocytes.

Answer 2

Type II hypersensitivity (cytotoxic)

Question 3

Hypersensitivity involving complement and Fc-receptor-mediated recruitment. Involves immune complexes of circulating Ag and IgG or IgM Ab.

Answer 3

Type III hypersensitivity (Immune Complex)

Question 4

Hypersensitivity involving CD4+ T cells, CD8+ T cells.

Answer 4

Type IV (Delayed Type) Hypersensitivity

Question 5

What are the clinical manifestations (syndromes) involved in immediate hypersensitivity?

Answer 5

• allergic rhinitis
• food allergies
• bronchial asthma
• anaphylaxis (fall in BP due to vascular dilation)

Question 6

What occurs in the sensitization phase?

Answer 6

1) 1st exposure to the allergen
2) Ag activation of Th2 cells and stimulation of IgE class switching in B cells.
3) The IgE binds to FC-e-R1 on mast cells.

Question 7

What occurs in the effector phase?

Answer 7

1) repeat exposure to Ag

2) Mast cell becomes activated. Mediators get released.

Question 8

IgE bound to the mast cell in a person w/ type I hypersensitivity is most likely to be…

Answer 8

polyclonal