Hormondruse - Prufung3 Flashcards
Where are glucocorticoids produced, and what is their fxn?
Adrenal cortex, regulate glucose metabolism
What is the endogenous adrenal corticoid?
cortisol
Where is cortisol produced?
Adrenal cortex - fasciculate and reticularis
How does cortisol’s production compare to aldosterone?
Produced 100x the level of aldosterone
The plasma concentration of this is 0.4 micromolar, and 96% of it is bound to corticosteroid binding globulin.
corticosol
Adrenal cortical hormones are derived from what?
cholesterol
This is the enzyme that converts 17-hydroxyprogesterone into 11-deoxycortisol.
Hint: 21-B-________-ase
21-B-hydroxylase.
It is a cytochrome P450 enzyme (p450C21)
Stressors signal production of _____ (what is the releasing hormone) –> this then triggers ACTH release –> ACTH triggers this gland _____ to secrete cortisol –> cortisol results in ____ (- or +) feedback at level of hypothalamus and pituitary.
CRH –> ACTH –> adrenal gland –> cortisol –> negative feedback
This is a disease caused by deficiency in biosynthetic enzymes (most commonly 21-B-hydroxylase). Results in masculinization, sexual precocity, accelerated linear growth. This is b/c biosynthesis diverts to DHEA and androstenedione.
No cortisol: can’t hvae negative feedback to hypothalamus’s CRH or pituitary ACTH –> so adrenal steroid biosynthesis increases –> adrenal hypertorphy
CAH: Congenital Adrenal Hyperplasa
What ist he treatment for CAH?
Glucocorticoid mineralocorticoid replacement
-earlier=better, for 2ndary sex characteristics
What is the receptor for ACTH called, and what type of receptor is it?
Name: MC2R (Melanocortin Type 2 Receptor)
Type: Gs-type G protein signaling receptor
- Signals via adenylyl cyclase (AC) to produce cAMP –> cAMP releases IP3 from ER and DAG from membrane –> activates PKC.
How does ACTH work? (What does it do)?
- Increases steroid synthesis
- Trophic effect on adrenal gland.
What type of receptor does cortisol hhave?
intracellular glucocorticoid receptor (GR) binds cortisol in cytoplasm –> translocates to nucleus –> activates transcription
This hormone stimulates FSH.
- Protein hormone
- Homodimer w/2 inhibin-B chains
- Stimulates release of FSH, but not LH
Activin
This hormone suppresses secretion of FSH, but not LH.
- Made by granulosa cells
- found in follicular fluid
- protein hormone
Inhibin (folliculostatin)