PRRs Flashcards
TLR4
LPS (G- bacteria)
TLR3
dsRNA (virus)
TLR7/8
ssRNA (virus)
TLR9
dsDNA (virus)
what TLR senses dsRNA
TLR3
what TLR senses ssRNA
TLR7/8
what TLR senses G- bacteria
TLR4
what TLR senses dsDNA
TLR9
what TLR detects LPS
TLR4
what TLR(s) detects viruses
TLR3, TLR7, TLR8, TLR9
name two DAMPs
HMGB1, HSP
HMGB1 is associated with
immunogenic cell death
HSP is associated with
fever; also anti-viral and anti-bacterial
what 3 signalling cascades are triggered by PAMP/DAMP binding
IRF3, MAPκ, NF-κβ
activation of IRF3 triggers production of which cytokines
IFNα/β
activation of MAPκ triggers production of which cytokines
IL-1, IL-6, TNFα (type I interferons)
activation of NF-κβ triggers production of which cytokines
IL-1, IL-6, TNFα
cytokines produced by PRR/DAMP or PAMP binding impact which three main areas of the body
bone marrow (leukocytosis), brain (sickness behaviour), liver (production of APPs)
