PRRs Flashcards
1
Q
TLR4
A
LPS (G- bacteria)
1
Q
TLR3
A
dsRNA (virus)
2
Q
TLR7/8
A
ssRNA (virus)
3
Q
TLR9
A
dsDNA (virus)
4
Q
what TLR senses dsRNA
A
TLR3
5
Q
what TLR senses ssRNA
A
TLR7/8
6
Q
what TLR senses G- bacteria
A
TLR4
7
Q
what TLR senses dsDNA
A
TLR9
8
Q
what TLR detects LPS
A
TLR4
9
Q
what TLR(s) detects viruses
A
TLR3, TLR7, TLR8, TLR9
10
Q
name two DAMPs
A
HMGB1, HSP
11
Q
HMGB1 is associated with
A
immunogenic cell death
12
Q
HSP is associated with
A
fever; also anti-viral and anti-bacterial
13
Q
what 3 signalling cascades are triggered by PAMP/DAMP binding
A
IRF3, MAPκ, NF-κβ
14
Q
activation of IRF3 triggers production of which cytokines
A
IFNα/β
