Proton Pump Inhibitors

Question 1

Proton Pump Inhibitors (PPI)

                         "prazole"

Answer 1

Omeprazole 
Esomeprazole
Lansoprazole
Pantoprazole
Rabeprazole

Question 2

Proton Pump Inhibitors (PPI)

                              Action

Answer 2

Act at specific secretory surface receptors to prevent the final step of acid production and thereby decrease the level of acid in the stomach

Question 3

Proton Pump Inhibitors (PPI)

                              Indications

Answer 3

Short-term treatment of active duodenal ulcers, GERD, erosive esophagitis, and benign active gastric disease

Long-term treatment of pathological hypersecretory conditions

Question 4

Proton Pump Inhibitors (PPI)

                    Contraindications

Answer 4

Allergy

Question 5

Proton Pump Inhibitors (PPI)

                              Caution

Answer 5

Pregnancy or lactation

Question 6

Proton Pump Inhibitors (PPI)

                      Adverse Effects

Answer 6

CNS effects: Dizziness, headache, asthenia, vertigo, insomnia, apathy

GI Effects: Diarrhea, abdominal pain, and tongue atrophy

Upper respiratory tract symptoms: Cough, stuff nose, hoarseness, and epistaxis

Question 7

Proton Pump Inhibitors (PPI)

                            Drug-Drug Interactions

Answer 7

Benzodiazepines, phenytoin, warfarin
Increase toxicity of these meds

Ketoconazole, theophylline
Decreased levels of these medications

Sucralfate
PPIs not absorbed well

Clopidogrel
Increase CV effects

Question 8

Proton Pump Inhibitors (PPI)

                        Assessment

Answer 8

History
Allergy
Pregnancy and lactation

Physical Exam
Neurological status, including level of orientation, affect, and reflexes

Abdominal assessment

Respiratory status, including respiratory rate and rhythm

Question 9

Proton Pump Inhibitors (PPI)

                           Nursing Diagnoses

Answer 9

Diarrhea

Risk for constipation

Imbalanced nutrition: less than body requirements

Disturbed sensory perception (kinesthetic, auditory)

Risk for injury

Deficient knowledge

Question 10

Proton Pump Inhibitors (PPI)

                                 Implementation

Answer 10

Administer drug before meals

Provide appropriate safety and comfort measures

Monitor the patient for diarrhea or constipation

Monitor the patient’s nutritional status

Provide thorough patient teaching

Question 11

Proton Pump Inhibitors (PPI)

                             Evaluation

Answer 11

Patient response

Effectiveness of teaching plan

Effectiveness of comfort measures

Compliance