Proto-oncogenes fig. 7-6 Flashcards
SIS (PBGFB)
activated through overexpression
associated with astrocytoma, osteosarcoma
growth factor category: PDGF-beta
HST1
activated through overexpression
associated w/ stomach cancer
growth factor category: Fibroblast growth factor
INT2 (FGF3)
activated by amplification
associated w/ bladder & breast cancer, melanoma
growth factor category: fibroblast growth factor
TGFA
activated through overexpression
associated w/ astrocytomas, hepatocellular carcinomas
growth factor: TGF-alpha
HGF
overexpression
thyroid cancer
growth factor category: HGF
ERBB1 (EGFR) ERRB2
overexpression
squamous cell carcinoma of the lung, gliomas
growth factor receptor: EGF-receptor family
FLT3
amplification
breast & ovarian cancers
FMS-like tyrosine kinase 3
RET
point mutation
leukemia, multiple endocrine neoplasia 2A & B, familial medullary thryoid carcinomas
receptor for neurotropic factors
PDGFRB
overexpression/ translocation
gliomas & leukemias
PDGF receptor
KIT
point mutation
gastrointestinal stromal tumors, seminomas, leukemias
receptor for stem cell factor
BRAF
point mutation
melanomas
involved w/ RAS signal transduction
beta-catenin
Point mutation/ overexpression
hepatoblastomas, hepatocellular carcinoma
involved w/ WNT signal transduction
