proteomics

Question 1

LXwhy are LXR/RXR implicated and inhibited

Answer 1

– lipid metabolism, cholesterol homeostasis,. these studies demonstrate that LXR agonists block the degradation of I-κB-α and suppress NF-κB DNA-binding activity in LPS-stimulated microglia, antiinflammatory effect

Question 2

lgals2 up

Answer 2

has been shown to induce apoptosis in activated T cells and is upregulated in placental tissue during CA

Question 3

gmppa down

Answer 3

metabolism

Question 4

glud1 down

Answer 4

metabolism knock-out in the brain of mice showed altered metabolic handling of glutamate

Question 5

serpinc1 down

Answer 5

anti inflammatory properties

Question 6

afm down

Answer 6

normal increases over course of pregnancy - transport protein

Question 7

s100a8/9 up

Answer 7

antimicrobial proteins promote inflammaoty rresponse by increasing production of chemokines thereby further amplifying pmn chemotaxis

Question 8

serpina3n up

Answer 8

acute phase response protein highly expressed in CNS, reactive astroctyes/microglia

Question 9

serpinB1a up

Answer 9

effective inhibitor of neutrophil serine protease, serving as a protective immunomodulator

Question 10

atp2b4 up

Answer 10

key for maintaining calcium homeostasis

Question 11

what are the serpin groups

Answer 11

serine protease inhibitiors (serine protease like neutrophil elastase in PMN), this inhibits elastase - helps to control inflammation helps to protect tissue from damage

Question 12

how is z score calculated

Answer 12

identify the activation or inhibition of upstream regulators based on changes in protein abundance or activity. formula with the observed value the expected value and SD. In proteomics, the z-score is used to assess how much the observed protein changes align with the expected behavior of upstream regulators.