Androgen

Question 1

androgen to estrogen conversion by

Answer 1

aromatase

Question 2

do hormones act directly on microglia?

Answer 2

could be direct or indirect (modulating microenvironments that impart sex difference din microglia identity and function)

Question 3

Whats condition girls have with excess androgen?

Answer 3

congenital adrenal hyperplasia (cortical synthesis pathway mutation)

Question 4

When do testes and ovary develop? What week?

Answer 4

6-12

Question 5

When does T peak in males human?

Answer 5

Week 12-18

Question 6

How much higher is male T in utero at 34-41 weeks than F?

Answer 6

10 times

Question 7

When is second peak of T after birth?

Answer 7

Around 3 months

Question 8

When does sexual differentiation of the genitals happen and then the brain?

Answer 8

G: 2 months of pregnancy
B: Second semester

Question 9

What’s a brain region organized by estradiol ?

Answer 9

Preoptic area - a brain region involved in many areas including copulatory and maternal behaviors

Question 10

In early development, what determines whether an animal will develop testes or ovaries?

Answer 10

Genes on the sex chromsome (SRY gene on Y chromosome) -> testes produce androgen and absence of SRY gene -> ovarian devlopment

Question 11

What does estrogen do in the rat brain?

Answer 11

1) masculinzation
2) defiminization

Question 12

Why use that does of flutamide?

Answer 12

Flutamide was administered at a dose of 50 mg/kg bodyweight and prepared on the same day as the injection. This dose was selected as it is well-established in impairing male reproductive development and preventing masculinization of anogenital distance (AGD)