Proteins and Amino Acids Flashcards

1
Q

What are the components of an amino acid?

A

Amino group
Acidic carboxyl group
Hydrogen atom
R group

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2
Q

Name the essential amino acids.

A

M - methionine
V - valine
W - tryptophan
F - phenylalanine
I - isoleucine
K - lysine
T - threonine
L -leucine
H - histidine

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3
Q

How is the amino group found in amino acids?

A

Protonated to NH3+

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4
Q

How is the carboxyl group found at physiological pH?

A

COO-

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5
Q

What is the carbon next to the carboxyl group called?

A

Alpha carbon
Chiral centre

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6
Q

How many stereoisomers can a molecule with a single chiral carbon have?

A

2

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7
Q

What is an enatiomer?

A

Stereoisomers which are mirror images of each other but cannot be superimposed on each other

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8
Q

What form are human amino acids found in?

A

L form

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9
Q

Where are D form amino acids found?

A

Peptides of bacterial cell walls and antibiotics

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10
Q

What amino acids have non-polar, aliphatic R groups?

A

G - Glycine
L - Leucine
I - Isoleucine
V - Valine
M - Methionine
A - Alanine
P - Proline

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11
Q

Which amino acid is actually an imino acid?

A

Proline

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12
Q

What does proline’s structure mean for its funciton?

A

Rigid structure means that it reduces flexibility of polypeptides that contain it e.g. collagen

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13
Q

What amino acids have aromatic R groups?

A

W - tryptophan
F - phenylalanine
Y - Tyrosine

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14
Q

Which amino acids with aromatic R groups are more polar?

A

Tyrosine - due to its OH group
Tryptophan - due to its N indole ring

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15
Q

What unique ability do tyrosine and tryptophan have?

A

Can absorb UV light

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16
Q

What amino acids have polar, uncharged R groups?

A

C - cysteine
Q - Glutamine
N - Asparagine
T - threonine
S - Serine

17
Q

What may happen to serine and threonine?

A

Phosphorylated at their OH group
Oligosaccharide group attached to their oxygen atom - O-glycosylation

18
Q

What may happen to asparagine?

A

Oligosaccharide group attached to its amide group - N-glycosylation

19
Q

What is unique about cysteine?

A

Sulfhydryl group gives it to ability to form strongly hydrophobic disulphide bonds

20
Q

What amino acids have positively charged R groups?

A

H - histidine
R - Arginine
K - Lysine

21
Q

Which amino acid is weakly basic and why?

A

Histidine due to the imidazole ring

22
Q

What amino acids have negatively charged R groups?

A

E - Glutamate
D - Aspartate

23
Q

Name an amino acid that exists as a free molecule.

A

Creatine

24
Q

What is the name of the bonds that link amino acids together?

A

Peptide bonds

25
Q

How are peptide bonds formed?

A

Condensation of the alpha-carboxyl of one amino acid with the alpha-amino of another