Proteins Flashcards

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1
Q

Glycosylation

A

Post Translational Modification
Starts at ER andcontinuous in Golgi Apparatus
Eg. Immunoglobulins, Glycoprotein
Protein Stabilisation, Solubility, Orientation, Signalling, Cell Recognision

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2
Q

Disulphide Bridges

A

Strong Covalent Bonds bw 2 cysteine residues (S-H)

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3
Q

Protein Denaturation Affects

A

2ry and 3ry Structure

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4
Q

Metalloprotein Functions?

A

Enzymes
Storage
Signalling
Transport

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5
Q

Globular

A

Enzymes
Messengers
Transporters
Structural Function in actin and tubulin

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6
Q

Fibrous

A

Bone Matrices
Muscle Fibre
Tendons
Connective Tissue

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7
Q

Co-operative binding

A

Binding to one sub-unit
Changes other sub-unit shapes
Increasing their ability to bind to a molecule

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8
Q

Anaemia

A

Single base change in DNA chain
A switched for T at position 6 of Bchain of haemoglobin
Glutamic acid (hydrophilic aa) is replaced by Valine (hydrophobic aa)
Deoxygenated HbS has abnormally low solubility
At low O2 levels crystals form
RBC change shape

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9
Q

Scurvy

A
VitC converts
Proline to hydroxyproline
Lysine to Hydroxylysine
Essential in stabilising crosslinks bw chains
Weaker Collagen
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10
Q

Osteogenesis Imperfecta

A
Glycine substituted for large amino acid
Protein can no longer fold to form a tight coil
Reduced Fibril Interaction
Loss of 2ry and 3ry Structure
Weakened brittle collage
Frequent fractures from a young age
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11
Q

Familial Hypercolesterolemia

A

Autosomal Dominant Disorder
LDL receptor mutatio
Elevated LDL blood concentration
Cholesterol deposition in skin, tendons, arteries

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