Proteinopathies Flashcards
List four neurodegenerative diseases the protein aggregates are found in
Alzheimer’s, Parkinson’s Huntington’s disease, ALS
List the clinical phenotype and molecular pathology for parkinson
Clinical phenotype: MSA, PSP, PD, and LBD
Molecular pathology: alpha-synuclein
List the clinical phenotype and molecular pathology for alzheimer’s disease
clinical phenotype: LO, AD, EO, PCA
Molecular path: alpha beta 42, p-Tau
What are biomarkers for DOPA?
Flurodopa PET, Troda SPECT
List the clinical phenotype and molecular pathology for FTD-ALS spectrum
Molecular pathology: Tau, TDP-43, FUS, UPS
Clinical phenotype: PPA (iogopenic and semantic and nonfluent), bvFTD, fvAD, ALS
What are biomarkers for amyloid?
ABeta 42 in CSF
AMyloid PET (PIB, AV45, etc)
What are biomarkers for Tau?
p-tau in CSF, tau PET (Flortaucipir, etc)
What are biomarkers for neurodegeneration?
MRI scan
T-Tau in CSF
FDG-PET
PH-Tau injection leads to __ __ 6 months post-injection
cognitive decline
Tau binds tightly to __
microtubules
PH-Tau disrupts __ and induces __ __
microtubules
membrane blebbing
T/F: PH-Tau toxic behavior can be transferred from cell to cell
True! like a prion-effect
PH-Tau __ neighboring cells and disrupts __
invades, microtubules
Transfer of PH-Tau between cells is __ __
cell specific
Recombinant Tau and PH-Tau enter cells that express __ __
muscarinic receptors
Recombinant tau and PH-tau enter __ neurons within __ __
primary
24 hours
Treatment of PH-Tau with __ blocks the __
atropine, uptake
In Alzheimer Disease P-Tau as PH-Tau is uptaken in the __ and destroys __
neurons; microtubules
T/F: atropine treatment blocks AD P-tau uptake
true
tcDCs reduces __ __ and upregulates HSP70 __
Tau accumulation
expression
Tau pathology is __ and is pivotal in the pathogenesis of __ and other tauopathies
primary
AD
Abnormal __ of tau is an early step in the process of __ degeneration
hyperphosphorylation
neurofibrillary
The combination of __ at Thr212, 231, and SER199 and 262 in the same tau molecule can trigger __ in __ and __
phosphorylation
toxicity
vitro, in vivo
List four new inducible mouse model recapitulates
oligomeric tau
truncated tau
early cognitive impairment
neuronal loss and astrocytes activation
