protein translation and post-translational modification Flashcards
post-translational modification: summarise the ways in which newly-synthesised proteins can be post-translationally modified
1
Q
purpose of post-translational modification
A
increases diversity
2
Q
ways of post-translational modification
A
disulphide bridges, proteolytic cleavage, glycosylation, phosphorylation, acylation (+lipid), hydroxylation, multimeric (multiple polypeptides)
3
Q
insulin as post-translational modification example
A
insulin from preproinsulin: 3 disulphide bonds in RER and Golgi; forms proinsulin; 2 proteolytic cleavages and release C chain in vesicle form insulin
