Protein Synthesis Inhibitors (Pharmacokinetics) Flashcards
1
Q
Chloramphenicol is administered via?
A
oral and parenteral
2
Q
Chloramphenicol can readily cross the:
A
- placenta
- blood-brain-barrier
2
Q
Chloramphenicol is excreted mainly through:
A
enterohepatic cycling
3
Q
A small fraction of chloramphenicol is excreted in?
A
urine (unchanged)
3
Q
Most of the chloramphenicol is inactivated by?
A
hepatic glucoronosyltransferase
4
Q
MOA: inhibits microbial protein synthesis and is bacteriostatic against most susceptible organisms. It binds reversibly to the 50S subunit of the bacterial
ribosome and inhibits peptide bond formation
A
Chloramphenicol
5
Q
Oral absorption is variable, especially for the older drugs, and may be impaired by foods and multivalent cations (calcium, iron, aluminum)
A
Tetracyclines
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