Protein Synthesis Inhibitors (Pharmacokinetics) Flashcards
1
Q
Chloramphenicol is administered via?
A
oral and parenteral
2
Q
Chloramphenicol can readily cross the:
A
- placenta
- blood-brain-barrier
2
Q
Chloramphenicol is excreted mainly through:
A
enterohepatic cycling
3
Q
A small fraction of chloramphenicol is excreted in?
A
urine (unchanged)
3
Q
Most of the chloramphenicol is inactivated by?
A
hepatic glucoronosyltransferase
4
Q
MOA: inhibits microbial protein synthesis and is bacteriostatic against most susceptible organisms. It binds reversibly to the 50S subunit of the bacterial
ribosome and inhibits peptide bond formation
A
Chloramphenicol
5
Q
Oral absorption is variable, especially for the older drugs, and may be impaired by foods and multivalent cations (calcium, iron, aluminum)
A
Tetracyclines
6
Q
A
7
Q
A
8
Q
A
9
Q
A
10
Q
A
11
Q
A
12
Q
A
13
Q
A
14
Q
A
15
Q
A
16
Q
A
17
Q
A
18
Q
A
19
Q
A
20
Q
A
21
Q
A
22
Q
A
23
Q
A
24
Q
A
25
Q
A
26
Q
A
27
Q
A
28
Q
A
29
Q
A
30
Q
A
31
Q
A
32
Q
A
33
Q
A
34
Q
A
35
Q
A
36
Q
A
37
Q
A
38
Q
A
39
Q
A
40
Q
A
41
Q
A
42
Q
A
43
Q
A
44
Q
A
45
Q
A
46
Q
A
47
Q
A
48
Q
A
49
Q
A
50
Q
A
51
Q
A
52
Q
A
53
Q
A
54
Q
A
55
Q
A
56
Q
A
57
Q
A
58
Q
A
